Navigation Links
Researchers Test Lithium as Radiation Protector
Date:4/1/2009

Study in mice hints at possible use in brain cancer treatment

WEDNESDAY, April 1 (HealthDay News) -- Lithium may help protect brain cells when people with brain cancer undergo radiation therapy, a new study suggests.

Cranial radiation therapy can cause long-term neurological effects, particularly in children, according to researchers from Vanderbilt University Medical Center in Nashville, Tenn. But they explain that lithium has brain-protective properties that might reduce these side effects.

In mice that underwent radiation therapy, the researchers found that lithium's promotion of DNA repair protected nerves in the brain's hippocampus. Lithium-treated mice had fewer double-strand DNA breaks than mice that were not given lithium.

"This decrease was associated with increased markers for the non-homologous end-joining DNA repair pathway," according to background information in a Vanderbilt news release. "When this pathway was blocked in the mice, lithium provided substantially less protection to the hippocampal nerve cells."

The finding led the authors to conclude that "lithium should be considered as a possible treatment to reduce the long-term neurological side effects of cranial radiation therapy, particularly in children."

And someday, they added, "targeted therapies to enhance DNA repair may provide an avenue to future therapeutic development."

The study was published in the Journal of Clinical Investigation.

More information

The U.S. National Cancer Institute has more about treatments for brain cancer in children.



-- Robert Preidt



SOURCE: Journal of Clinical Investigation, news release, April 1, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Test Lithium as Radiation Protector
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary ... Dallas that it will receive two significant new grants to support its work ... marked its 25th anniversary by recognizing patients, medical professionals and scientists for their ...
(Date:6/24/2016)... ... ... BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for a ... an hour by 2020 and then adjusting it yearly to increase at the same rate ... assure the wage floor does not erode again, and make future increases more predictable. , ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions today ... cultivation and processing operations at its production facility, and opened its first two ... the manufacturer of a complete system of proactive air and surface purification solutions ...
(Date:6/24/2016)... ... June 24, 2016 , ... Today, MTI-GlobalStem, a provider ... and other difficult to transfect cells, announces its launch of the PluriQ™ G9™ ... Editing System is a complete system for culturing and transfecting human pluripotent ...
(Date:6/24/2016)... ... June 24, 2016 , ... Southern Illinois University ... co-chairs for the Illinois State Dental Society (ISDS) Foundation’s Mission of Mercy (MOM). ... Convention Center in Collinsville. , They expect to treat approximately 2,000 ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Research and Markets has announced the ... Tests" report to their offering. ... The World Market for Companion Diagnostics covers the ... analysis in the report includes the following: ... Kits) by Region (N. America, EU, ROW), 2015-2020 , ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: