Navigation Links
Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage,

Molecular Medicine, a bimonthly, biomedical journal published by The Feinstein Institute for Medical Research, strives to understand normal body functioning and disease pathogenesis at the molecular level which may allow researchers and physician-scientists to use that knowledge in the design of specific molecular tools for disease diagnosis, treatment, prognosis, and prevention. Featured in the November/December issue: “Chronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Oxidation”, “Angiogenesis and Diabetes: Different Responses to Pro-Angiogenic Factors in the Chorioallantoic Membrane Assay”, and “Estradiol’s Salutary Effects on Keratinocytes following Trauma-Hemorrhage Are Mediated by Estrogen Receptor (ER)- and ER-”.

(Vocus) November 14, 2008 -- Chronic Lymphocytic Leukemia (CLL) is a disease of the B lymphocytes of the immune system. Under normal conditions, B lymphocytes (or B cells) play an important role in battling infection. CLL is a disease manifested by uncontrolled growth of these B lymphocytes. In this month’s issue of Molecular Medicine, Rosa Catera and her colleagues found that CLL cells react with cells undergoing programmed cell death (apoptosis), and those with the worst outcomes have the most potent reactivity. CLL comes in several forms and has different outcomes for patients. Some can live for years or decades with few symptoms, while others progress quickly into advanced stages of disease and thus have a shorter life expectancy.

Catera and her colleagues have been trying to unravel a curious observation that many of the antibodies in CLL patients share a similar genetic sequence, no matter where in the world they live. The finding suggests that apoptosis generates substances that could stimulate CLL cell growth. In laboratory models, they have shown that this type of reactivity is seen in a small subset of B cells, suggesting that CLL might evolve from this type of normal B lymphocyte. Chronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Oxidation. Rosa Catera and colleagues can be reached at rcatera @

In other major news in the journal, scientists at INSERM in France have evidence that hyperglycemia impedes therapeutic angiogenesis, which could be a problem when designing ways to test these new treatment. Angiogenesis and Diabetes: Different Responses to Pro-Angiogenic Factors in the Chorioallantoic Membrane Assay Giovana Di Marco, Etienne Larger and colleagues can be reached at Scientists at the University of Alabama report stunning findings of estrogen receptor involvement in trauma and hemorrhage. Estradiol’s Salutary Effects on Keratinocytes following Trauma-Hemorrhage Are Mediated by Estrogen Receptor (ER)-± and ER-². Fariba Moeinpour, Irshad H Chaudry and colleagues can be reached at Irshad.Chaudry @

To read the journal online and view this month’s popular podcast go to For more information contact Margot Puerta, managing editor of Molecular Medicine at 516-562-1129.


Read the full story at

Source: PRWeb
Copyright©2008 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
Related Image:
Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage,
(Date:11/29/2015)... , ... November 29, 2015 , ... While conventional walkers ... or provide ready access to exercise weights. Fortunately, an inventor from Uniontown, Pa., has ... TOMMY WALKER to enhance the benefits of a standard walker to improve the user’s ...
(Date:11/29/2015)... ... November 29, 2015 , ... Effective immediately, every single IguanaMed scrub style ... Black Friday Target is offering a “Buy One Scrub Set, Get the 2nd Scrub ... to purchase IguanaMed at a discounted price. , IguanaMed’s mission is to ...
(Date:11/28/2015)... ... 28, 2015 , ... Safe storage for contraceptive devices may not always be ... New Jersey and the other from Bradley Beach, New Jersey, there is an easy ... of having to replace NuvaRings more often than necessary. As such, it affords peace ...
(Date:11/28/2015)... CA (PRWEB) , ... November 28, 2015 , ... Pixel ... fully customizable media panels to choose from, the possibilities are endless. Users have full ... more. With the ProPanel: Pulse masking effects, users are sure to get heads to ...
(Date:11/27/2015)... ... , ... According to an article published November 6th by The ... of British Columbia suggested that laws requiring bicyclists to wear helmets may not actually ... the reason for the controversial conclusion is that, while helmets have certainly prevented a ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... ) ... "2016 Global Tumor Marker Testing Market: Supplier ... Segment Forecasts, Innovative Technologies, Instrumentation Review, Competitive ... offering. --> ) has ... Global Tumor Marker Testing Market: Supplier Shares ...
(Date:11/26/2015)... 26 november 2015 AAIPharma Services ... geplande investering aan van ten minste $15,8 ... en het mondiale hoofdkantoor in ... resulteren in extra kantoorruimte en extra capaciteit ... groeiende behoeften van de farmaceutische en biotechnologische ...
(Date:11/26/2015)... 26, 2015 --> ... SyMRI to find optimal contrast weighting of MRI for ... has signed a research agreement with SyntheticMR in order to ... SyMRI, it is possible to generate multiple contrast images from ... patient has left, thus making it possible to both fine ...
Breaking Medicine Technology: