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Researchers Suggest That Oxidative Stress is Strongly Evident in the In-Utero Environment of the Fetus With Down Syndrome
Date:6/2/2009

ential treatment in vitro.

"While more research is needed, this study illuminates a possible pathway to treating some aspects of Down syndrome in the womb," Bianchi said. "While we do not know the extent to which the developing fetus is affected by oxidative stress, we know this abnormal environment is not conducive to optimal development."

The analysis relied heavily on computer analysis and bioinformatics. To support their conclusions, the researchers applied the Connectivity Map, a tool linking information about genomics and FDA-approved compounds to suggest drug therapies for various disease pathways. This approach implicated the same underlying processes, and suggests directions for future work.


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SOURCE Tufts Medical Center
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