Navigation Links
Researchers Suggest That Oxidative Stress is Strongly Evident in the In-Utero Environment of the Fetus With Down Syndrome

Abnormal gene expression in amniotic fluid could play role in suggesting potential therapies

BOSTON, June 2 /PRNewswire-USNewswire/ -- A paper published in the Proceedings of the National Academy of Sciences ( by Tufts Medical Center and Tufts University researchers reports that amniotic fluid surrounding Down syndrome fetuses shows oxidative stress, a condition that could harm fetal cells and play a role in affected individuals. The results demonstrate secondary adverse consequences of Down syndrome and suggest potential prenatal therapies.

Diana Bianchi, M.D., Vice Chair for Research, Department of Pediatrics at Floating Hospital for Children at Tufts Medical Center, and Donna Slonim, Ph.D., Associate Professor of Computer Science at Tufts University, conducted an analysis of the human genome from cell-free fetal messenger RNA in amniotic fluid surrounding fetuses. Their team identified molecular and biochemical pathway changes that were evident in the Down syndrome fetuses as compared to normal fetuses as early as the fourth month of pregnancy.

Down syndrome occurs when an individual has three copies of chromosome 21 instead of two. The longstanding assumption has been that proteins produced by the additional copy of chromosome 21 were almost exclusively responsible for the atypical development and function associated with the syndrome. A surprising aspect of the findings was that the molecular abnormalities observed were predominantly produced by genes on the other chromosomes.

As a next step, researchers are examining amniotic cells to determine if they show similar genomic profiles to the cell-free material in the fluid. If that is the case, they will begin to look at the effectiveness of anti-oxidant compounds as potential treatment in vitro.

"While more research is needed, this study illuminates a possible pathway to treating some aspects of Down syndrome in the womb," Bianchi said. "While we do not know the extent to which the developing fetus is affected by oxidative stress, we know this abnormal environment is not conducive to optimal development."

The analysis relied heavily on computer analysis and bioinformatics. To support their conclusions, the researchers applied the Connectivity Map, a tool linking information about genomics and FDA-approved compounds to suggest drug therapies for various disease pathways. This approach implicated the same underlying processes, and suggests directions for future work.

SOURCE Tufts Medical Center
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Researchers call for new space headache category following astronauts survey
2. Outsmarting Brain Tumors: Cedars-Sinai Researchers, Neurosurgeons and Other Experts Present Free Conference for Adult Brain Tumor Patients and Caregivers
3. U-M researchers link pathway to breast cancer stem cells
4. Researchers determine predicting factors of positive lung cancer diagnoses in chest radiographs
5. Researchers Spot Genes Linked to Testicular Cancer
6. UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage
7. Pitt melanoma researchers present novel findings at ASCO
8. Researchers develop light-treatment device to improve sleep quality in the elderly
9. MU researchers offer insights for advancing health communication through digital media
10. Mayo researchers help discover genetic cause for primary biliary cirrhosis
11. BUSM researchers find no adjustment method fully resolves confounding by indication
Post Your Comments:
(Date:6/26/2016)... , ... June 26, 2016 , ... PawPaws brand ... new product that was developed to enhance the health of felines. The formula is ... The two main herbs in the PawPaws Cat Kidney Support Supplement Soft ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... ... ... Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and Mental ... exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took place ... BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive an ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... ... 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ... raise to $12 an hour by 2020 and then adjusting it yearly to increase at ... the minimum wage, assure the wage floor does not erode again, and make future increases ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... June 23, 2016 Capricor ... ), a biotechnology company focused on the discovery, ... that patient enrollment in its ongoing randomized HOPE-Duchenne ... exceeded 50% of its 24-patient target. Capricor expects ... third quarter of 2016, and to report top ...
(Date:6/23/2016)... 23, 2016 , , , ... 7, 2016 , , , , LOCATION: , , , ... , , , EXPERT PANELISTS:  , , , Frost & Sullivan,s ... Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program ... global pharmaceutical industry is witnessing an exceptional era. Several new demand ...
Breaking Medicine Technology: