Navigation Links
Researchers Spot Genes Linked to Testicular Cancer
Date:6/1/2009

Discovery could help determine which men are at increased risk, scientists say

MONDAY, June 1 (HealthDay News) -- U.S. scientists say they've identified key gene variants tied to an increased risk of testicular cancer.

They said the findings are an important step toward understanding which men are at high risk for the disease.

"Despite being quite heritable, there really have not been any clear genetic risk factors that can account for most cases of testicular cancer. These variants are the first striking genetic risk factors found for this disease to date," Dr. Katherine L. Nathanson, an assistant professor of medicine at the University of Pennsylvania School of Medicine and a specialist in medical genetics at the Abramson Cancer Center, said in a news release.

Nathanson and colleagues found that men with two copies of the common version of the c-KIT ligand (KITLG) gene are 4.5 times more likely to develop testicular cancer than men with two copies of the less common versions of the gene.

The researchers also found that men with two copies of the common version of variants next to another gene called sprouty 4 (SPRY4) are almost 1.5 times more likely to develop testicular cancer than men with two copies of the less common version of the gene.

The study appears online in the journal Nature Genetics.

Environmental exposure has been suspected as a factor in the growing incidence of testicular cancer, which is the most common cancer among young men, the study authors note. This study shows that genes also play a major role in a man's risk of developing the disease.

"This finding is quite different than those observed in many other genome-wide association studies," Nathanson said. "In most studies, the increased risk of disease is associated with the less common variant of the gene. In this case, it is the more common variant in Caucasians that is associated with risk. If you carry two copies of the less common variant you are probably at incredibly low risk."

More information

The American Cancer Society has more about testicular cancer.



-- Robert Preidt



SOURCE: University of Pennsylvania School of Medicine, news release, May 31, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage
2. Pitt melanoma researchers present novel findings at ASCO
3. Researchers develop light-treatment device to improve sleep quality in the elderly
4. MU researchers offer insights for advancing health communication through digital media
5. Mayo researchers help discover genetic cause for primary biliary cirrhosis
6. BUSM researchers find no adjustment method fully resolves confounding by indication
7. Researchers gain ground in efforts to fight parasite infection
8. Poor attention in kindergarten predicts lower high school test scores, UC Davis researchers find
9. NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development
10. Mayo Clinic Researchers Examine the Psychological Impact of Child Abuse
11. Mayo Clinic researchers examine the psychological impact of child abuse
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Spot Genes Linked to Testicular Cancer
(Date:8/18/2017)... ... August 18, 2017 , ... Mediaplanet today announces the launch ... lifestyles and highlighting the importance of proactive eye and ear health. The campaign ... latest innovations in hearing aid technology. , In this issue, the American ...
(Date:8/18/2017)... ... 18, 2017 , ... Radabaugh & Associates, a family managed ... North-Central West Virginia, is embarking on a cooperative charity effort with the Chestnut ... The Chestnut Mountain Ranch (CMR) is a Christ-centered boarding school for young men ...
(Date:8/18/2017)... ... August 18, 2017 , ... Goss & Associates Insurance Agency, ... commercial clients in the greater Houston region, is helping locally recognized nonprofit Addi’s ... against cancer. , Founded by Tony and Amber Bender after losing their young ...
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... says will lift the veil on false teachings pertaining to the mother of the Savior ... teach, you see a far different picture of the role of this historical woman. ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Our Mountains to Climb: A ... a couple that grew stronger together through the faith they shared to overcome struggles ... is the creation of published author, Barbara J. Corcoran, a retired teacher and happily ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... (NYSE: DPLO), the nation,s largest independent specialty pharmacy, announced financial ... unless otherwise noted, are to the quarter ended June 30, ... 2017 Highlights include: Revenue of $1,126 ... Total prescriptions dispensed of 220,000, compared to 241,000 ... Gross profit per prescription dispensed of $371, ...
(Date:8/4/2017)... , Aug. 3, 2017  Agragen, LLC, ... company active in the biopharmaceutical, nutraceutical, and aquacultural ... development of its lead drug candidates, AGR131.  This ... proinflammatory cytokine from the blood of patients suffering ... and inflammatory bowel disease. ...
(Date:8/2/2017)... , Aug. 2, 2017   Marshall County Hospital in Benton, Kentucky ... reduce the risk of hospital-acquired infections (HAIs). The new addition, Tru-D SmartUVC , short ... to kill deadly pathogens such as C. diff , MRSA, MERS, Ebola and more. ... Tru-D SmartUVC ... Tru-D in action in a patient room ...
Breaking Medicine Technology: