Navigation Links
Researchers Spot Genes Linked to Testicular Cancer
Date:6/1/2009

Discovery could help determine which men are at increased risk, scientists say

MONDAY, June 1 (HealthDay News) -- U.S. scientists say they've identified key gene variants tied to an increased risk of testicular cancer.

They said the findings are an important step toward understanding which men are at high risk for the disease.

"Despite being quite heritable, there really have not been any clear genetic risk factors that can account for most cases of testicular cancer. These variants are the first striking genetic risk factors found for this disease to date," Dr. Katherine L. Nathanson, an assistant professor of medicine at the University of Pennsylvania School of Medicine and a specialist in medical genetics at the Abramson Cancer Center, said in a news release.

Nathanson and colleagues found that men with two copies of the common version of the c-KIT ligand (KITLG) gene are 4.5 times more likely to develop testicular cancer than men with two copies of the less common versions of the gene.

The researchers also found that men with two copies of the common version of variants next to another gene called sprouty 4 (SPRY4) are almost 1.5 times more likely to develop testicular cancer than men with two copies of the less common version of the gene.

The study appears online in the journal Nature Genetics.

Environmental exposure has been suspected as a factor in the growing incidence of testicular cancer, which is the most common cancer among young men, the study authors note. This study shows that genes also play a major role in a man's risk of developing the disease.

"This finding is quite different than those observed in many other genome-wide association studies," Nathanson said. "In most studies, the increased risk of disease is associated with the less common variant of the gene. In this case, it is the more common variant in Caucasians that is associated with risk. If you carry two copies of the less common variant you are probably at incredibly low risk."

More information

The American Cancer Society has more about testicular cancer.



-- Robert Preidt



SOURCE: University of Pennsylvania School of Medicine, news release, May 31, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. UCLA cancer researchers first to link intestinal inflammation with systemic chromosome damage
2. Pitt melanoma researchers present novel findings at ASCO
3. Researchers develop light-treatment device to improve sleep quality in the elderly
4. MU researchers offer insights for advancing health communication through digital media
5. Mayo researchers help discover genetic cause for primary biliary cirrhosis
6. BUSM researchers find no adjustment method fully resolves confounding by indication
7. Researchers gain ground in efforts to fight parasite infection
8. Poor attention in kindergarten predicts lower high school test scores, UC Davis researchers find
9. NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development
10. Mayo Clinic Researchers Examine the Psychological Impact of Child Abuse
11. Mayo Clinic researchers examine the psychological impact of child abuse
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Spot Genes Linked to Testicular Cancer
(Date:1/20/2017)... ... January 20, 2017 , ... “The Angel”: a heartwarming and earnest tale ... each of his children. “The Angel” is the creation of published author, Marjorie Lund-Fontaine, ... City, and impassioned writer. , When asked of her new book, Marjorie says, “‘The ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... “I Forgive You”: a fine examination ... “I Forgive You” is the creation of published author, Stephen Miller, who, for over ten ... has gracefully given to him. Born in Trinidad and Tobago, he has been serving the ...
(Date:1/20/2017)... ... ... “Christmas in Suffolk”: a story of love, secrets, and mystery. “Christmas ... Indiana where she works in a daycare and looks for inspiration in the local ... Faith Publishing, Sara Seymour’s new book is an adventure of love and secrets. ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Knowledge is God’s Lighthouse”: a moving and ... God’s Lighthouse” is the creation of published author, Gene Gaapf, a retired truck driver, ... , “I have been writing since high school and have many different titles,” Gaapf ...
(Date:1/20/2017)... ... ... “God's Miracle Man: Against All Odds”: an inspiring affirmation of God’s ... C. A. Tucker, son of Minister Delores Pinnock and a Jamaican native who lives ... , “While sitting up in bed, I felt a pounding headache. It was like ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... Jan 20, 2017 Research and Markets ... By Type ([CBC, HGB/HCT, BMP, BUN Creatinine, Electrolyte Testing, HbA1c Testing, ... And Segment Forecasts, 2013 - 2024" report to their offering. ... The global ... by 2024 Introduction of innovative solutions on the grounds ...
(Date:1/20/2017)... 20, 2017  Ethicon Endo-Surgery, Inc. announced ... Products, Inc., a privately held medical device ... tools used in operating rooms worldwide. The ... advanced energy devices with Megadyne,s innovative portfolio ... forward in Ethicon,s goal to deliver the ...
(Date:1/20/2017)... Research and Markets has announced the addition of the ... to their offering. ... This research service on the global pharmaceutical stability testing market ... of the key participants in the market. The ... 2020. The market is expected to grow at a CAGR of ...
Breaking Medicine Technology: