Navigation Links
Researchers Report Combined Molecules in Red Wine by Far Exceed the Biological Activity of Plain Resveratrol, Consistent With the Composition of Longevinex(R)

SAN DIMAS, Calif., March 10 /PRNewswire/ -- A recent CBS 60 Minutes TV program drew considerable attention to resveratrol (rez-vair-ah-trawl), a red wine molecule believed to largely be responsible for the French Paradox, the fact the French have far more people living beyond 100 years and exhibit a far lower mortality rate from heart disease than other people living in other developed countries, despite the high-calorie, high-fat diet in France.


Now researchers in Sweden report that the full array of molecules provided in red wine by far exceed the biological effects of plain resveratrol.

The results of the study are consistent with an earlier research study conducted among mice which showed that the combination of resveratrol, quercetin and rice bran phytate-IP6 (Longevinex(R)) exerted a 9-times greater genomic effect than plain resveratrol or a calorie restricted diet. [Experimental Gerontology 2008 Sep; 43(9):859-66]

Researchers instilled various white and resveratrol-rich red wines as well as research-grade resveratrol into lab dishes with various types of cells (brain, lung, colon, cervical, kidney). Surprisingly researchers found the total array of molecules in red wine, but not white wine, produced a far greater biological effect than resveratrol alone. Furthermore, the beneficial effects were produced independently from alcohol or activation of the Sirtuin1 gene, considered a survival and longevity gene.

Only at higher concentrations did resveratrol cause unhealthy cells to die off (21%), compared to untreated cells (6%). Such a high concentration may produce long-term side effects in humans. But within 24 hours, red wine abolished virtually all (100%) the unhealthy cells. Red wine exerted its effect by disarming protective antioxidant systems.

Researchers caution that this is only a lab dish study and that the results are theoretical. But they seem to mirror the health-giving properties attributed red wine as observed in human populations in France.

The researchers speculate that "instead of a single molecule (like resveratrol) present in wine, ... the combination of molecules in red wine ... contribute result in a combined effect with positive outcome."

Bill Sardi, spokesperson for Longevinex(R) (long-jev-in-ex), says nutriceuticals have distinct advantages over drugs because they often provide an array of molecules, whereas the FDA prefers to approve single-molecule drugs.

"The synergism that nature produces, as seen in wine, may never be reproduced in prescription drugs for this reason," says Sardi. "The development of a plain resveratrol drug may not be as productive as first imagined," he says.

The patent-pending Longevinex(R) formula provides an array of molecules including three found naturally in red wine - resveratrol, quercetin and ferulic acid. The dosage of these molecules in Longevinex(R) is equivalent to what is provided in 3-5 glasses of red wine (180-300 mg), considered the safe and effective range observed in wine-drinking populations. [British Medical Journal 1991 September 7; 303(6802): 565-568] Longevinex(R) is designed to deliver the health benefits of red wine without the alcohol, calories or sulfite preservatives.

The study was published in an early online edition (March 4, 2009) of Experimental Cell Research.

For more information about Longevinex(R), please visit

Reference: Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1. Experimental Cell Research 2009 Mar 4. [Epub ahead of print]

SOURCE Longevinex
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
(Date:11/30/2015)... , ... November 30, 2015 , ... At Grand Dental ... and convenient setting. , When you have dental problems, you need to turn to ... can effectively diagnose and treat your needs, a friendly dentist who counsels you on ...
(Date:11/30/2015)... ... , ... Using a combination of two blood sugar tests rather than a ... a new study by researchers at the School of Public Health at Georgia State ... of Blood Glucose Tests ,” published in Frontiers in Public Health, the researchers noted ...
(Date:11/30/2015)... ... November 30, 2015 , ... Newly ... out of Glen Ridge, NJ. He has both advanced training and considerable ... He is also an expert in cosmetic dentistry. He is an active ...
(Date:11/30/2015)... ... 2015 , ... International telepathology consultations can significantly improve patient ... Diagnostics researchers. Their review of more than 1,500 pathology cases submitted electronically ... significantly altered treatment plans for more than half of the cases in which ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ”Dying Words: The ... be released on December 1, 2015, to coincide with World AIDS Day. The multi-media ... journalist who covered the AIDS epidemic as he was dying of the disease. , ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... 30, 2015  IBA Molecular North America, Inc. (IBAMNA), ... radiopharmaceuticals, announced that as of January 1, 2016, it ... The decision to rebrand the company reflects a refined ... as its close relationship with Zevacor Molecular.  Both IBAMNA ... Science (IHS). Peter Burke , Vice ...
(Date:11/30/2015)... , November 30, 2015 North ... and is expected to grow at a CAGR of 7.6% from ... was valued at USD 135.6 million in 2014, and is expected ... --> According to the new Market Research Report "North ... non-invasive), By End User (Hospitals, ambulatory care, others) - Analysis And ...
(Date:11/30/2015)... , Nov. 30, 2015  Kevin Smith ... Sensium Healthcare, a global pioneer in wireless monitoring ... Boston, MA , Mr. Smith will ... Sensium,s global commercial strategy.  He will also directly ... to build clinical evidence for SensiumVitals, the first ...
Breaking Medicine Technology: