SAN DIMAS, Calif., March 10 /PRNewswire/ -- A recent CBS 60 Minutes TV program drew considerable attention to resveratrol (rez-vair-ah-trawl), a red wine molecule believed to largely be responsible for the French Paradox, the fact the French have far more people living beyond 100 years and exhibit a far lower mortality rate from heart disease than other people living in other developed countries, despite the high-calorie, high-fat diet in France.
Now researchers in Sweden report that the full array of molecules provided in red wine by far exceed the biological effects of plain resveratrol.
The results of the study are consistent with an earlier research study conducted among mice which showed that the combination of resveratrol, quercetin and rice bran phytate-IP6 (Longevinex(R)) exerted a 9-times greater genomic effect than plain resveratrol or a calorie restricted diet. [Experimental Gerontology 2008 Sep; 43(9):859-66]
Researchers instilled various white and resveratrol-rich red wines as well as research-grade resveratrol into lab dishes with various types of cells (brain, lung, colon, cervical, kidney). Surprisingly researchers found the total array of molecules in red wine, but not white wine, produced a far greater biological effect than resveratrol alone. Furthermore, the beneficial effects were produced independently from alcohol or activation of the Sirtuin1 gene, considered a survival and longevity gene.
Only at higher concentrations did resveratrol cause unhealthy cells to die off (21%), compared to untreated cells (6%). Such a high concentration may produce long-term side effects in humans. But within 24 hours, red wine abolished virtually all (100%) the unhealthy cells. Red wine exerted its effect by disarming protective antioxidant systems.
Researchers caution that this is only a lab dish study and that the results are theoretical. But they seem to mirror the health-giving properties attributed red wine as observed in human populations in France.
The researchers speculate that "instead of a single molecule (like resveratrol) present in wine, ... the combination of molecules in red wine ... contribute result in a combined effect with positive outcome."
Bill Sardi, spokesperson for Longevinex(R) (long-jev-in-ex), says nutriceuticals have distinct advantages over drugs because they often provide an array of molecules, whereas the FDA prefers to approve single-molecule drugs.
"The synergism that nature produces, as seen in wine, may never be reproduced in prescription drugs for this reason," says Sardi. "The development of a plain resveratrol drug may not be as productive as first imagined," he says.
The patent-pending Longevinex(R) formula provides an array of molecules including three found naturally in red wine - resveratrol, quercetin and ferulic acid. The dosage of these molecules in Longevinex(R) is equivalent to what is provided in 3-5 glasses of red wine (180-300 mg), considered the safe and effective range observed in wine-drinking populations. [British Medical Journal 1991 September 7; 303(6802): 565-568] Longevinex(R) is designed to deliver the health benefits of red wine without the alcohol, calories or sulfite preservatives.
The study was published in an early online edition (March 4, 2009) of Experimental Cell Research.
For more information about Longevinex(R), please visit www.longevinex.com
Reference: Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1. Experimental Cell Research 2009 Mar 4. [Epub ahead of print]
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