Navigation Links
Researchers Repair Damage Caused by Heart Attacks in Mice
Date:4/18/2012

WEDNESDAY, April 18 (HealthDay News) -- Scientists report they were able to repair mouse hearts that were damaged by heart attacks.

Researchers from the Gladstone Institutes successfully converted scar tissue in the mice into beating heart muscle. Their findings, they said, might eventually lead to a similar treatment for people who've had heart attacks.

"The damage from a heart attack is typically permanent because heart-muscle cells -- deprived of oxygen during the attack -- die and scar tissue forms," Dr. Deepak Srivastava, who directs cardiovascular and stem cell research at Gladstone, a nonprofit biomedical research institution, said in a Gladstone news release. "But our experiments in mice are a proof of concept that we can reprogram non-beating cells directly into fully functional, beating heart cells -- offering an innovative and less invasive way to restore heart function after a heart attack."

In conducting the study, the researchers delivered three genes, known as GMT, involved in embryonic heart development directly into the damaged areas of the mouse hearts. They found the non-beating scar tissue was transformed into beating heart muscle within one month. The heart function of the mice improved even more after three months, the study added.

"These findings could have a significant impact on heart-failure patients -- whose damaged hearts make it difficult for them to engage in normal activities like walking up a flight of stairs," Li Qian, a postdoctoral scholar, who is also a California Institute for Regenerative Medicine postdoctoral scholar and a Roddenberry Fellow, said in the news release. "This research may result in a much-needed alternative to heart transplants -- for which donors are extremely limited. And because we are reprogramming cells directly in the heart, we eliminate the need to surgically implant cells that were created in a petri dish."

The next step, the study authors noted, is to duplicate their research and test its safety in larger mammals, such as pigs. This will bring the scientists one step closer to testing this type of treatment in people.

"We hope that our research will lay the foundation for initiating cardiac repair soon after a heart attack -- perhaps even when the patient arrives in the emergency room," said Srivastava, who is also a professor at the University of California, San Francisco, with which Gladstone is affiliated.

The findings were published online April 18 in the journal Nature.

In the future, the scientists say they hope this type of direct reprogramming will be used to also treat spinal cord injury and illnesses such as Alzheimer's and Parkinson's disease.

While the findings of the new study are promising, scientists note that research involving animals often fails to produce similar results in humans.

More information

The U.S. National Heart, Lung, and Blood Institute provides more information on heart attacks.

-- Mary Elizabeth Dallas

SOURCE: Gladstone Institutes, news release, April 17, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Repair Damage Caused by Heart Attacks in Mice
(Date:4/28/2016)... , ... April 28, 2016 , ... Head Over Heels ... 9 Western Championships. The competition will be held at the University of Montana on ... gymnasts west of the Mississippi River. , In order to qualify, Varize needed to ...
(Date:4/28/2016)... ... April 28, 2016 , ... ... open availability of a new CDISC standard, Clinical Trial Registry (CTR) XML. ... This innovative standard will make it possible to build applications that generate ...
(Date:4/28/2016)... ... April 28, 2016 , ... Cosmetic Town, an online ... cosmetictown.com . The forum section was recently revamped and upgraded to allow even more ... in use across the country. , According to the senior editor of Cosmetic Town, ...
(Date:4/28/2016)... ... 2016 , ... Greener Hydroponics is now offering a large selection of Smart ... organic farmers and nurseries according to Sales Manager Joe Steele who says, “Now is ... is to offer wholesale level pricing and ultra-fast shipping for growers of any size.” ...
(Date:4/28/2016)... ... April 28, 2016 , ... In 2011, TIME magazine ... the emerging field of biomechatronics, technology that marries human physiology with electromechanics. He continues ... He is also the Founder of BionX , a leader in the field ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 27, 2016 ... in Zürich gab Strekin AG den Start ... zur Erhaltung des Resthörvermögens von Patienten, denen ... die umfassende Phase-II-Doppelblindstudie mit Placebo-Kontrollgruppe werden momentan ... wird während der Operation direkt ins Mittelohr ...
(Date:4/27/2016)... PARIS , April 27, 2016 ... Year-Over-Year Including 42% Growth in Recurring Consumable Sales  ... Mauna Kea Technologies (Euronext: MKEA, OTCQX: MKEAY) ... today announced its sales for the first quarter ended ... business and the execution of its commercial strategy. ...
(Date:4/27/2016)... 2016 Transparency Market Research has ... - Global Industry Analysis, Size, Share, Growth, Trends, and ... global skincare devices market was valued at US$ 7,255.8 ... a CAGR of 10.1% from 2015 to 2023 to ... the full Skincare Devices Market (Treatment Device - LED Therapy ...
Breaking Medicine Technology: