Navigation Links
Researchers Rejuvenate Blood-Forming Stem Cells in Mice
Date:5/3/2012

THURSDAY, May 3 (HealthDay News) -- Researchers who found a way to rejuvenate aged blood-forming cells in mice say their achievement offers clues about how it may be possible to combat health problems associated with old age.

The study by scientists at Cincinnati Children's Hospital Medical Center and Ulm University Medicine in Germany appeared online May 3 in the journal Cell Stem Cell.

Hematopoietic (meaning "to make blood") stem cells, which originate in the bone marrow, produce all of the body's red and white blood cells and platelets. As people age, these cells increase in number but become but less effective at generating new blood cells and immune cells. This makes older people more susceptible to infections and diseases, including leukemia.

In laboratory experiments with mouse cells, the researchers found that a specific protein that regulates cell aging also controls a process that causes blood-making stem cells to age. Using drugs to inhibit the action of this protein (called Cdc42) reversed aging of the hematopoietic stem cells and restored their function to a level similar to that of younger stem cells.

It had been believed that the aging of hematopoietic stem cells was locked in by nature and could not be reversed by using drugs, according to a hospital news release.

"Our findings suggest a novel and important role for Cdc42, and identify its activity as a target for ameliorating natural [hematopoietic stem cell] aging," principal investigator Hartmut Geiger, of the University of Ulm, said in the release. "We know the aging of [these stem cells] reduces in part the response of the immune system response in older people, which contributes to diseases such as anemia and may be the cause of tissue attrition in certain systems of the body."

Researchers say the next step is to test a protein inhibitor in mice to see how hematopoietic stem cells and various tissues respond. The researchers also are gathering samples of human blood-making stem cells for future lab tests.

Although studies involving animals can be useful, they frequently fail to produce similar results in humans.

More information

Visit the American Society of Hematology to learn about blood basics.

-- Robert Preidt

SOURCE: Cincinnati Children's Hospital Medical Center, news release, April, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. CNIO researchers describe new functions of cohesin relevant for human disease
2. Biomedical researchers receive Hartwell Foundation awards
3. Kessler Foundation researchers present at first International Congress on Cognition in MS
4. Researchers gain better understanding of mechanism behind tau spreading in the brain
5. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
6. Researchers determine vitamin D blood level for reducing major medical risks in older adults
7. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
8. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
9. Moffitt Cancer Center researchers working at frontiers of melanoma research
10. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
11. UCLA researchers combat global disease with a cell phone, Google Maps and a lot of ingenuity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Rejuvenate Blood-Forming Stem Cells in Mice
(Date:3/25/2017)... ... March 25, 2017 , ... Getting earned media coverage meaningful for ... , All through the year, Garden Media aims to provide material helpful to ... influencers and pitching client’s key messages to gain coveted media placements, Garden ...
(Date:3/24/2017)... ... March 24, 2017 , ... Infectious disease affects billions of ... United States, it’s a threat that is constantly changing and evolving. Mediaplanet's “Fighting ... offers strategies for the healthcare community to help decrease the number of completely ...
(Date:3/24/2017)... ... ... The iaedp Foundation, the premier provider of educational programs and training standards for eating ... of disordered eating, announced today that the 2017 Symposium set a new attendance record ... countries converged on the Green Valley Resort in Las Vegas. , “We are ...
(Date:3/24/2017)... ... 24, 2017 , ... Northridge dentists, Dr. Michel ... sleep apnea and TMJ at their office. TMJ, or temporomandibular joint disorder, has ... type, is increasingly being treated at dental offices with newly developed procedures and ...
(Date:3/24/2017)... Texas (PRWEB) , ... March 24, 2017 , ... ... 2017 the year of enhancements, upgrading their training and leads programs. , In ... University. Reserved for elite sales agents, Performance Partners is designed to teach how ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Research and Markets has announced the addition of the "Deep ... to their offering. ... The Deep Learning: Drug Discovery and Diagnostics Market, 2017-2035 report examines ... deep learning solutions within the healthcare domain. Primarily driven by the ... solution to generate relevant insights from medical data. ...
(Date:3/24/2017)... , March 24, 2017 Global ... industry including definitions, classifications, applications and industry chain structure. ... market including development history, competitive landscape analysis, and major ... ... spread across 105 pages providing 10 company profiles and ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... their offering. ... provides separate comprehensive analytics for the US, Canada , ... Asia-Pacific , Latin America , and Rest of ... 2022. Also, a six-year historic analysis is provided for these markets. Market ...
Breaking Medicine Technology: