Navigation Links
Researchers Rejuvenate Blood-Forming Stem Cells in Mice
Date:5/3/2012

THURSDAY, May 3 (HealthDay News) -- Researchers who found a way to rejuvenate aged blood-forming cells in mice say their achievement offers clues about how it may be possible to combat health problems associated with old age.

The study by scientists at Cincinnati Children's Hospital Medical Center and Ulm University Medicine in Germany appeared online May 3 in the journal Cell Stem Cell.

Hematopoietic (meaning "to make blood") stem cells, which originate in the bone marrow, produce all of the body's red and white blood cells and platelets. As people age, these cells increase in number but become but less effective at generating new blood cells and immune cells. This makes older people more susceptible to infections and diseases, including leukemia.

In laboratory experiments with mouse cells, the researchers found that a specific protein that regulates cell aging also controls a process that causes blood-making stem cells to age. Using drugs to inhibit the action of this protein (called Cdc42) reversed aging of the hematopoietic stem cells and restored their function to a level similar to that of younger stem cells.

It had been believed that the aging of hematopoietic stem cells was locked in by nature and could not be reversed by using drugs, according to a hospital news release.

"Our findings suggest a novel and important role for Cdc42, and identify its activity as a target for ameliorating natural [hematopoietic stem cell] aging," principal investigator Hartmut Geiger, of the University of Ulm, said in the release. "We know the aging of [these stem cells] reduces in part the response of the immune system response in older people, which contributes to diseases such as anemia and may be the cause of tissue attrition in certain systems of the body."

Researchers say the next step is to test a protein inhibitor in mice to see how hematopoietic stem cells and various tissues respond. The researchers also are gathering samples of human blood-making stem cells for future lab tests.

Although studies involving animals can be useful, they frequently fail to produce similar results in humans.

More information

Visit the American Society of Hematology to learn about blood basics.

-- Robert Preidt

SOURCE: Cincinnati Children's Hospital Medical Center, news release, April, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. CNIO researchers describe new functions of cohesin relevant for human disease
2. Biomedical researchers receive Hartwell Foundation awards
3. Kessler Foundation researchers present at first International Congress on Cognition in MS
4. Researchers gain better understanding of mechanism behind tau spreading in the brain
5. Moffitt Cancer Center researchers identify drivers of sarcoma growth and survival
6. Researchers determine vitamin D blood level for reducing major medical risks in older adults
7. Researchers creating designer lymph nodes based on Moffitts Total Cancer Care initiative
8. Moffitt researchers find adolescents with cancer concerned about their future reproductive health
9. Moffitt Cancer Center researchers working at frontiers of melanoma research
10. Moffitt Cancer Center researchers: Quality of life as important as quantity of life
11. UCLA researchers combat global disease with a cell phone, Google Maps and a lot of ingenuity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Rejuvenate Blood-Forming Stem Cells in Mice
(Date:2/9/2016)... VA (PRWEB) , ... February 09, 2016 , ... ... Small Mammal Prize has officially been won. A team from 21st Century Medicine ... discovered a way to preserve the delicate neural circuits of an intact rabbit ...
(Date:2/8/2016)... D.C. (PRWEB) , ... February 08, 2016 , ... ... officially launched its newly redesigned website, federallabs.org . The site houses a ... or license available federal technologies through the process called technology transfer (T2). As ...
(Date:2/8/2016)... City, GA (PRWEB) , ... February 08, 2016 , ... ... and cavity-free. February is National Children’s Dental Health Month and family dentist Yvonne Dorrian, ... 3 p.m. at Coast Dental , located next to Target at 1207 North ...
(Date:2/8/2016)... Texas (PRWEB) , ... February 08, 2016 , ... The Valentine’s Season is famous for ... members and significant others that they are loved. This year, for more than 5.6 ... they cost - just won't be enough to remind them of the lives they’ve led ...
(Date:2/8/2016)... ... February 08, 2016 , ... ... case packer for pouches, bags, and flow wrapped products at WestPack 2015, February ... specialty product manufacturers step up to semi-automatic or fully-automatic case packing with a ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... , Feb. 9, 2016  Bluestar Silicones will promote ... line for long-term implant applications and announce certification ... & Manufacturing (MD&M) West Conference (Booth #1759), February ... --> --> Available in ... LSRs offer outstanding physical properties enabling our customers ...
(Date:2/8/2016)... Respiratory Devices - Medical Devices Pipeline Assessment, 2015 ... " Respiratory Devices - Medical Devices Pipeline Assessment, ... currently in pipeline stage. The report provides ... analysis of the products at various stages of ... the pipeline product development. It also provides information ...
(Date:2/8/2016)... 8, 2016 CBG Technologies, a U.S. ... Solvent Recycling Systems, specifically designed for precision parts ... new and existing vapor degreasers, parts washers and ... through continuous recycling and recovers 100% of the ... --> Precision parts manufacturers benefit from ...
Breaking Medicine Technology: