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Researchers Pinpoint Link Between Caloric Restriction and Longevity
Date:9/20/2007

l trials of SRT501, a SIRT1 activator based on resveratrol, a compound found in red wine.

"This paper indicates that several other sirtuins, SIRT3 and SIRT4, also play an important role in sensing the energy environment and linking calorie restriction to beneficial effects on health," said Sirtris Chief Executive Officer Christoph Westphal.

"We have continued to develop new drugs to target SIRT1, but we also think SIRT3 and SIRT4 are going to be very promising drug targets," he added.

More information

For more on calorie restriction, visit the Calorie Restriction Society.



SOURCES: David Sinclair, Ph.D., director, Paul F. Glenn Laboratories for Aging Research, Harvard Medical School, Boston; Christoph Westphal, M.D., Ph.D., CEO and vice chairman, Sirtris Pharmaceuticals, Cambridge, Mass.; Shin-ichiro Imai, M.D., Ph.D., assistant professor, Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St. Louis; Sept. 21, 2007, Cell


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