Navigation Links
Researchers Map Paths Governing Neuron Function
Date:1/29/2008

Findings identify proteins that determine nature of connections between neurons

TUESDAY, Jan. 29 (HealthDay News) -- U.S. researchers have mapped thousands of neuronal proteins that are connected in complex signaling networks that control neuron function.

This line of research may help improve understanding of brain development, neurodegenerative diseases, and treatment of spinal cord injuries, a new study says.

The University of California, San Diego (UCSD), School of Medicine team used quantitative mass spectrometry, computational software and bioinformatics to match these proteins to their cellular functions.

The researchers developed a way to isolate and purify neurites, which are long membrane extensions from the neuron that give rise to axons (which primarily receive signals) or dendrites (which primarily send signals). This new technology will help improve understanding about how neurites form and differentiate to regenerate neuronal connections.

The UCSD team also discovered how key signaling molecules are regulated by a complex protein network that control neurite outgrowth.

The formation of neurites is the first step in the differentiation of neurons in the central nervous system.

"Understanding how neurites form is crucial, as these structures give rise to the specialized axons and dendrites which relay sensory input and enable us to see, hear, taste, reason and dream," team leader Richard Klemke, a professor of pathology at UCSD School of Medicine and the Moores UCSD Cancer Center, said in a prepared statement.

"Our primary goal is to identify unique proteins that cause the neurite to sprout and differentiate. We also want to understand the underlying signals that guide neurite formation and migration in response to directional cues," Klemke said.

The study was published in this week's issue of the Proceedings of the National Academy of Sciences.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about neurons.



-- Robert Preidt



SOURCE: University of California, San Diego, news release, Jan. 28, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Map Paths Governing Neuron Function
(Date:6/26/2016)... Aliso Viejo, California (PRWEB) , ... June 26, 2016 , ... ... for Final Cut Pro X. , "Film editors can give their videos a whole ... artistically," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... , ... The temporary closing of Bruton Memorial Library on June 21 due to a possible ... often overlooked aspect of head lice: the parasite’s ability to live away from a human ... but a necessary one in the event that lice have simply gotten out of control. ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern ... Laude and his M.D from the David Geffen School of Medicine at UCLA. He ... Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program ...
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016  Collagen Matrix, Inc., ("Collagen Matrix") ... manufacturing of collagen and mineral based medical devices ... Bill Messer has joined the company ... leverage the growing portfolio of oral surgery, neurosurgery, ... Bill joins the Collagen Matrix executive team as ...
(Date:6/24/2016)... , June 24, 2016   Bay ... Rehabilitation Network,s Dean Center for Tick Borne ... Medicine and Rehabilitation, MIT Hacking Medicine, University of ... Innovation, today announced the five finalists of ... Lyme disease.  More than 100 scientists, clinicians, researchers, ...
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
Breaking Medicine Technology: