Navigation Links
Researchers Map Paths Governing Neuron Function
Date:1/29/2008

Findings identify proteins that determine nature of connections between neurons

TUESDAY, Jan. 29 (HealthDay News) -- U.S. researchers have mapped thousands of neuronal proteins that are connected in complex signaling networks that control neuron function.

This line of research may help improve understanding of brain development, neurodegenerative diseases, and treatment of spinal cord injuries, a new study says.

The University of California, San Diego (UCSD), School of Medicine team used quantitative mass spectrometry, computational software and bioinformatics to match these proteins to their cellular functions.

The researchers developed a way to isolate and purify neurites, which are long membrane extensions from the neuron that give rise to axons (which primarily receive signals) or dendrites (which primarily send signals). This new technology will help improve understanding about how neurites form and differentiate to regenerate neuronal connections.

The UCSD team also discovered how key signaling molecules are regulated by a complex protein network that control neurite outgrowth.

The formation of neurites is the first step in the differentiation of neurons in the central nervous system.

"Understanding how neurites form is crucial, as these structures give rise to the specialized axons and dendrites which relay sensory input and enable us to see, hear, taste, reason and dream," team leader Richard Klemke, a professor of pathology at UCSD School of Medicine and the Moores UCSD Cancer Center, said in a prepared statement.

"Our primary goal is to identify unique proteins that cause the neurite to sprout and differentiate. We also want to understand the underlying signals that guide neurite formation and migration in response to directional cues," Klemke said.

The study was published in this week's issue of the Proceedings of the National Academy of Sciences.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about neurons.



-- Robert Preidt



SOURCE: University of California, San Diego, news release, Jan. 28, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Map Paths Governing Neuron Function
(Date:6/24/2017)... ... June 24, 2017 , ... Doorknobs are for convenience, deadbolts ... as getting a guard dog or having an alarm system installed. But unless there ... forced entry. Yair Frenkel, owner of TX Premier Locksmith in Killeen, TX says: “In ...
(Date:6/23/2017)... ... June 23, 2017 , ... Yesterday, U.S. Senate Republicans revealed ... repeal and replace the Affordable Care Act (ACA). Like the bill narrowly passed ... Medicaid, a public health insurance program for low-income children, pregnant women, parents of ...
(Date:6/23/2017)... ... 23, 2017 , ... Military Connection friend and veteran advocate Micaela ... Virgin Atlantic lounge. , Bensko is no stranger to the plight of the ... her life to supporting our wounded veterans. A world-class photographer, her riveting photos “The ...
(Date:6/23/2017)... ... June 23, 2017 , ... Ensuring meat products ... videos highlight the importance of correctly using a meat thermometer. The videos feature ... extensive research on consumer food safety habits. Dr. Bruhn explains the variety of ...
(Date:6/23/2017)... ... 23, 2017 , ... PureLife Dental is pleased to announce that California Dental ... As part of the amalgam separator endorsement, all CDA members may purchase an ECO ... the retail value. This partnership between PureLife and CDA is especially timely as it ...
Breaking Medicine News(10 mins):
(Date:6/1/2017)... 1, 2017 Nutriceutical Holdings (NH), parent company ... (VRS), and KD Pharma Group have decided to join ... KD Pharma Group. KD Pharma Group will become the ... acquire the entire company. "We believe we ... committed to growing the NH companies by providing us ...
(Date:5/26/2017)... 26, 2017  Endo International plc (NASDAQ: ENDP ... CEO, will represent the Company in a fireside chat at ... Tuesday, June 13, 2017 at 10:40 a.m. PT / 1:40 ... in Rancho Palos Verdes, CA. ... will be available on the Company,s website at http://www.endo.com/investors/overview ...
(Date:5/22/2017)... , May 22, 2017  As the specialty ... whole continue to make the revolutionary shift from ... important for ensuring positive patient outcomes and shaping ... are shifting focus away from clinical trials and ... of long-term specialty drug therapy utilization in precise ...
Breaking Medicine Technology: