Navigation Links
Researchers Make Stem Cells That Secrete Insulin
Date:2/20/2008

Mouse study suggests it could help control diabetes in humans

WEDNESDAY, Feb. 20 (HealthDay News) -- Scientists have found a way to convert human embryonic stem (ES) cells into cells that release insulin in response to glucose and ease a diabetes-like condition in mice, a new study says.

Further research and development of this technique could lead to a renewable source of cells for treatment of people with diabetes, according to Emmanuel Baetge, of Novocell Inc., in San Diego, and colleagues, who published their work online in the current issue of Nature Biotechnology.

Type 1 and some forms of type 2 diabetes involve the loss of pancreatic beta cells, which regulate blood glucose (sugar) levels by releasing insulin, according to background information in a news release about the study.

In previous work, Baetge and the team were able to coax human ES cells part of the way toward becoming beta cells, but not far enough for them to carry out the key function of mature beta cells, which is the release of insulin in response to glucose.

In this new study, the researchers transplanted immature beta cells derived from human ES cells into mice whose beta cells had been destroyed by chemical treatment. After one to three months, the transplanted cells developed into glucose-responsive, insulin-secreting cells and helped control blood glucose levels in the mice.

Previous research demonstrated that transplantation of pancreatic beta cells (within islets) can help control diabetes in humans. But the therapy relies on cells from donor pancreases, meaning that the supply of such cells is limited. That's why scientists are trying to develop alternative sources of beta cells, such as those derived from human ES cells.

More information

The American Diabetes Association has more about islet transplantation.



-- Robert Preidt



SOURCE: Nature Biotechnology, news release, Feb. 20, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. U of M researchers determine structure of protein that mutates DNA of the AIDS virus HIV-1
2. Researchers create first chikungunya animal model
3. Researchers aim to prevent global prematurity and stillbirths
4. Researchers Aim to Prevent Global Prematurity and Stillbirths
5. UH researchers study Hispanic childrens activities, views on places to play
6. Researchers discover new way to reverse poor circulation and heal wounds
7. Bacterial toxin closes gate on immune response, Penn researchers discover
8. UD researchers discover technique for repairing gene defect that causes spinal muscular atrophy
9. Veterinary researchers study poultry virus as human cancer treatment
10. UD researchers discover promising technique for repairing gene that causes spinal muscular atrophy
11. Researchers at BMC find disability does not necessarily follow disease in living to old age
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Make Stem Cells That Secrete Insulin
(Date:12/5/2016)... ... December 05, 2016 , ... ... and relationship-marketing firm, announced today that nominations will be accepted from December ... (ISE®) Central Awards. , Awards include the Information Security Executive® of the ...
(Date:12/5/2016)... ... December 05, 2016 , ... ... Meeting through tomorrow, December 6th, sparks a conversation about epilepsy, bearing down on ... in 26 people will be diagnosed with epilepsy within their lifetime. With such ...
(Date:12/5/2016)... , ... December 05, 2016 ... ... interoperability, today announced that the company will provide alerting technology to Central ... been recently awarded $1.7 million in federal funds as the sole sub-recipient ...
(Date:12/5/2016)... ... December 05, 2016 , ... Dr. Barry M. Weintraub, one ... Surgery, who recently participated in the 36th Annual Cutting Edge Aesthetic Symposium at the ... techniques for getting that perfect, yet natural-looking, nose. Dr. Weintraub, who is world-renowned for ...
(Date:12/5/2016)... , ... December 05, 2016 , ... ... Officer for the Florida Hospital West Florida Region. McGuinness brings experience in executive ... and engaging staff, physicians and leaders. , In her new role, that officially ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... , Dec. 5, 2016  BD (Becton, Dickinson ... global medical technology company, will demonstrate an enhanced technology ... management technologies, including the company,s leading Pyxis™ and Alaris™ ... Pharmacists (ASHP) 2016 Midyear Meeting being held in ... While national data show that approximately 68 ...
(Date:12/5/2016)... Research and Markets has announced the addition of the "Global ... and Demand Forecast to 2022" report to their offering. ... , , ... market is expected to grow at a CAGR of 4.5% during ... witnessing high growth, due to growing female geriatric population and increasing ...
(Date:12/5/2016)... England , December 5, 2016 ... Transitions to Deputy Chairman   ... on selectively targeting deubiquitylating enzymes (DUBs) to treat cancer, neurodegenerative ... has been appointed as non-executive Chairman, effective January 1 st ... of Mission Therapeutics as a non-executive Director in July 2015. ...
Breaking Medicine Technology: