Navigation Links
Researchers Look at Genomes of Nonsmokers With Lung Cancer
Date:1/9/2012

MONDAY, Jan. 9 (HealthDay News) -- Scientists who have started to identify genes and pathways associated with lung cancer in people who have never smoked say it's a first step in the potential development of new treatments.

Never-smokers -- people who've smoked fewer than 100 cigarettes over a lifetime -- account for about 10 percent of lung cancer cases.

But this group of lung cancer patients hasn't been studied as much as smokers who develop lung cancer, according to Timothy Whitsett, a senior postdoctoral fellow in the cancer and cell biology division at the Translational Genomics Research Institute in Phoenix.

He and his colleagues conducted genetic analyses on three female patients with adenocarcinoma of the lung, a form of non-small cell lung cancer. One was a never-smoker with early-stage disease, one was a never-smoker with late-stage disease and one was a smoker with early-stage disease.

"In the never-smoker with early-stage cancer, there were very few mutations in the genome, but when we looked at the whole transcriptome, we saw differences in gene expression," Whitsett said in a news release from the American Association for Cancer Research.

The never-smoker with late-stage disease had mutations in what Whitsett called "classic tumor-suppressor genes." It's possible that mutations of the tumor-suppressor genes may be a factor in late-stage lung cancer in never-smokers, the researchers said.

The tumors in both never-smokers lacked alterations in common genes associated with lung cancer, such as EGFR, KRAS and EML/ALK translocations. This suggests that these patients are ideal cases for the discovery of new mutations associated with lung adenocarcinomas in never-smokers, according to Whitsett and colleagues.

The study was slated for presentation Monday at an AACR/International Association for the Study of Lung Cancer joint conference on lung cancer, held in San Diego.

"This is the
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Look at Genomes of Nonsmokers With Lung Cancer
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... Conseco, Inc. (NYSE:,CNO) announced that Todd M. Hacker is ... president and treasurer. He will report to Ed,Bonach, Conseco,s ... Conseco from YRC Worldwide, where he was vice,president and ... From 2005-2006, he was senior vice president, finance and,administration, ...
... MCKINNEY, Texas, Jan. 8 Torchmark Corporation,(NYSE: TMK ... market,closes on Wednesday, February 6, 2008. In conjunction with ... listen to a,conference call that will be broadcast live ... a.m. Eastern. At that time a copy of the,Company,s ...
... HGR ) announced today that it plans to report ... on Monday, February 11,2008., The Company plans to issue ... 31, 2007 on Monday, February 11, 2008, after the,close of ... 9:00,a.m., EST, on Tuesday, February 12, 2008. Those wishing to ...
... LAKES, N.J., Jan. 8 Medco Health,Solutions, Inc. (NYSE: ... Jr. today,reiterated the company,s positive outlook for 2008 at ... The company reiterated its guidance for 2008 GAAP diluted ... assets that,existed when Medco became a publicly traded company, ...
... of developing breast cancer among people who carry the BRCA1 ... January 9/16 issue of JAMA. , BRCA1 and BRCA2 are ... magnitude of the risk of breast cancer in BRCA1 and ... options. The risk of breast cancer in BRCA1 and ...
... likely to undergo heart, liver and kidney transplantation , , TUESDAY, ... and rural areas are less likely to get organ transplants ... study found. , The study of almost 175,000 potential transplant ... percent to 15 percent less likely to be wait-listed and ...
Cached Medicine News:Health News:Torchmark Corporation Announces Fourth Quarter 2007 Earnings Release and Conference Call 2Health News:Hanger Orthopedic Group, Inc. Announces 2007 Year-End Earnings Release Conference Call 2Health News:Medco CEO Reiterates Guidance, Positive Outlook for 2008 2Health News:Breast cancer risk varies significantly among BRCA1 and BRCA2 carriers 2Health News:Rural Residents Get Fewer Organ Transplants: Study 2Health News:Rural Residents Get Fewer Organ Transplants: Study 3
(Date:1/15/2014)... , Jan. 15, 2014 Massachusetts General ... AMGN ) announced today that they ... and validate new therapeutic targets and develop novel ... disorder that affects millions worldwide. The MGH-Broad-Amgen collaboration ... IBD biology, human genetics, genomic technology, and drug ...
(Date:1/15/2014)...  Humberto C. Antunes,  Galderma  worldwide CEO, will receive ... Journal of Drugs in Dermatology (JDD) at the ... event is January 17-20, 2014, at the Omni Orlando Resort at ... The ODAC is a distinguished event that delivers ... clinical and aesthetic dermatology practitioners in the 21 st ...
(Date:1/15/2014)... , Jan. 15, 2014  Manufacturers, ... and technologies must be able to protect ... (IP). (Logo: http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ... nature of the Medical Device Industry, it ... industry sectors of cases involving IP infringement. ...
Breaking Medicine Technology:Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4Intellectual Property Insurance for Medical-related Products and Services 2
Immuno-turbidimetric assay for Free Protein Sby STA© Analyzers. Suspension of microparticles coated with monoclonal antibodies to Free Protein S....
Colorimetric Assay of Unfractionated and Low Molecular Weight Heparins by STA© Analyzers. Lyophilized, patent-pending chromogenic substate, CBS 52.44 of ~4.2 moles/vial and bovine factor Xa ~1.1...
Substrate Plasma for Factor VII Assay by STA© Analyzers. Freeze-dried human plasma from which factor VII has been removed by selective immuno-adsorption....
Substrate Plasma for Factor IX Assay by STA© Analyzers. Freeze-dried human plasma from which factor IX has been removed by selective immuno-adsorption....
Medicine Products: