Navigation Links
Researchers Look at Genomes of Nonsmokers With Lung Cancer
Date:1/9/2012

MONDAY, Jan. 9 (HealthDay News) -- Scientists who have started to identify genes and pathways associated with lung cancer in people who have never smoked say it's a first step in the potential development of new treatments.

Never-smokers -- people who've smoked fewer than 100 cigarettes over a lifetime -- account for about 10 percent of lung cancer cases.

But this group of lung cancer patients hasn't been studied as much as smokers who develop lung cancer, according to Timothy Whitsett, a senior postdoctoral fellow in the cancer and cell biology division at the Translational Genomics Research Institute in Phoenix.

He and his colleagues conducted genetic analyses on three female patients with adenocarcinoma of the lung, a form of non-small cell lung cancer. One was a never-smoker with early-stage disease, one was a never-smoker with late-stage disease and one was a smoker with early-stage disease.

"In the never-smoker with early-stage cancer, there were very few mutations in the genome, but when we looked at the whole transcriptome, we saw differences in gene expression," Whitsett said in a news release from the American Association for Cancer Research.

The never-smoker with late-stage disease had mutations in what Whitsett called "classic tumor-suppressor genes." It's possible that mutations of the tumor-suppressor genes may be a factor in late-stage lung cancer in never-smokers, the researchers said.

The tumors in both never-smokers lacked alterations in common genes associated with lung cancer, such as EGFR, KRAS and EML/ALK translocations. This suggests that these patients are ideal cases for the discovery of new mutations associated with lung adenocarcinomas in never-smokers, according to Whitsett and colleagues.

The study was slated for presentation Monday at an AACR/International Association for the Study of Lung Cancer joint conference on lung cancer, held in San Diego.

"This is the
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Look at Genomes of Nonsmokers With Lung Cancer
(Date:12/19/2014)... Cranbury, NJ (PRWEB) December 19, 2014 ... of Inside Patient Care: Pharmacy & Clinics™, an ... entire healthcare team treating and caring for patients ... As primary care expands to provide optimal access ... Clinics™ offers a forum for the team treating ...
(Date:12/19/2014)... (PRWEB) December 19, 2014 ... the diagnostic, personalized medicine, healthcare information technology, and ... the position of Chief Operating Officer. The announcement ... Partners, marked by a strengthened presence in Boston ... , "Leslie lives and breathes the client experience," ...
(Date:12/19/2014)... in good shape seems to reduce your risk of high ... more than 57,000 Americans, including more than 35,000 with high ... Those in the poorest shape had a more than ... start of the study, compared to a 50 percent chance ... more than 8,000 people diagnosed with high blood pressure during ...
(Date:12/19/2014)... 18, 2014 (HealthDay News) -- Traveling through the same ... virus to three others within a four-hour time span, ... new report shows. "The exposures in this report ... than an international terminal, highlighting the fact that measles ... Vega, an infectious disease specialist at the U.S. Centers ...
(Date:12/17/2014)... 17, 2014 Unidesk Corporation today ... (ACOM), which welcomed its inaugural class in August ... to seamlessly support bring your own device (BYOD) ... – experience. The solution, comprised of Citrix ... Dell server and storage infrastructure and ...
Breaking Medicine News(10 mins):Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 2Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 3Health News:Slone Partners Promotes Leslie Loveless to Chief Operating Officer 2Health News:Being Fit Keeps Blood Pressure in Check 2Health News:Arriving Now at Gate 42: Measles 2Health News:Arriving Now at Gate 42: Measles 3Health News:Alabama College of Osteopathic Medicine Deploys Desktop Virtualization Solution from Citrix, Dell and Unidesk 2Health News:Alabama College of Osteopathic Medicine Deploys Desktop Virtualization Solution from Citrix, Dell and Unidesk 3
... , WASHINGTON , Feb. 14 Following is the ... http://www.newscom.com/cgi-bin/prnh/20090226/CENSUSLOGO ) , SUNDAY, FEBRUARY 14 : ... for the 14th day of Black History Month.  Dr. Daniel Hale ... end of the 19th century.  He founded Provident Hospital, the nation,s first ...
... , AUSTIN, Texas , Feb. 13 ... are sources of satisfaction for many gardeners. For allergy sufferers, though, ... , Pollen from trees, shrub and grasses can cause an onslaught ... cases, an asthma attack. , But sensitive people can take a ...
... improve on your personal best , SATURDAY, Feb. 13 (HealthDay News) ... you can learn from them if you want to improve your ... us to push the boundaries of human potential. As I tell ... mimic the strategies of those at the top," Chris Sebelski, an ...
... , ... largest provider of Microsoft certifications in North America, is proud to announce that CED Solutions ... for the first 500 applicants starting today. Students will also obtain a licensed copy ... ...
... ... the President,s proposed budget. , ... (PRWEB) February 13, 2010 -- President Obama presented America and Congress with his new budget ... presented throughout its 192 pages. Mountainside Addiction Treatment Center has scrubbed through the budget ...
... , , WASHINGTON , Feb. 12 ... pleased to announce that its contract with the U.S. Department of ... 30, 2010 . , "Since HITSP,s formation in 2005, the Panel ... electronic health records," said Fran Schrotter , HITSP project director ...
Cached Medicine News:Health News:U.S. Census Bureau Black History Month Feature for Feb. 14 2Health News:Avoid Allergens to Reap the Rewards of Gardening 2Health News:Avoid Allergens to Reap the Rewards of Gardening 3Health News:Train Like an Olympian: Here's How 2Health News:CED Solutions Offers Free 3-Day Technical Windows 7 Certification Course for Unemployed Individuals 2Health News:New York and Connecticut Drug Rehab Center Mountainside Weighs In on Latest White House Budget 2Health News:New York and Connecticut Drug Rehab Center Mountainside Weighs In on Latest White House Budget 3Health News:HITSP Contract With U.S. HHS Extended Through April 2010 2Health News:HITSP Contract With U.S. HHS Extended Through April 2010 3
(Date:12/19/2014)... Mass. , Dec. 18, 2014  Decision Resources ... the United States will increase to ... will be primarily driven by expansion in the large ... energy devices will be increasingly adopted due to the ... Other key findings from Decision Resources Group,s ...
(Date:12/19/2014)... -- Baptist Health Lexington is the first facility in ... Fibrillation with Electrophysiology Services (EPS) Accreditation status from the Society ... the most common cardiac arrhythmia and has become recognized as ... stroke and possible death. More than 5 million patients in ... and the numbers are rapidly increasing as the population ages. ...
(Date:12/19/2014)... and LYON, France , Dec. 19, ... LLY ) and Adocia (Euronext Paris: FR0011184241 – ADOC) ... an ultra-rapid insulin, known as BioChaperone Lispro, for treatment ... BioChaperone Lispro relies on Adocia,s proprietary BioChaperone® technology and ... and Adocia will develop BioChaperone Lispro with the goal ...
Breaking Medicine Technology:U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 2U.S. Laparoscopic Device Market Will Reach Over $4.3 Billion by 2023 3Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 2Lilly and Adocia Announce Alliance to Co-Develop Ultra-Rapid Insulin Based on BioChaperone Technology 3
... SARcode Corporation presented data today for their lead investigational ... trial, subjects receiving SAR 1118 demonstrated a reduction in ... as compared to placebo. These data were part of ... Vision and Ophthalmology (ARVO) Annual Meeting held in Fort ...
... 3, 2011 At the Board of Directors meeting held ... per share. The dividend is payable on June 15, 2011 ... About Sigma-Aldrich: Sigma-Aldrich is a leading ... to Improve the Quality of Life. Its chemical and biochemical ...
Cached Medicine Technology:SAR 1118 Demonstrates Encouraging Results in Phase 2 Study of Dry Eye Disease 2SAR 1118 Demonstrates Encouraging Results in Phase 2 Study of Dry Eye Disease 3
... The model 55S Rocking Shaker provides ... and blotted membranes. The very slow ... degree of tilt provide a gentle ... over gels and blotted membranes to ...
Conversion Kits For Modular Incubator Chamber...
Inquire...
Inquire...
Medicine Products: