Navigation Links
Researchers Look at Genomes of Nonsmokers With Lung Cancer
Date:1/9/2012

MONDAY, Jan. 9 (HealthDay News) -- Scientists who have started to identify genes and pathways associated with lung cancer in people who have never smoked say it's a first step in the potential development of new treatments.

Never-smokers -- people who've smoked fewer than 100 cigarettes over a lifetime -- account for about 10 percent of lung cancer cases.

But this group of lung cancer patients hasn't been studied as much as smokers who develop lung cancer, according to Timothy Whitsett, a senior postdoctoral fellow in the cancer and cell biology division at the Translational Genomics Research Institute in Phoenix.

He and his colleagues conducted genetic analyses on three female patients with adenocarcinoma of the lung, a form of non-small cell lung cancer. One was a never-smoker with early-stage disease, one was a never-smoker with late-stage disease and one was a smoker with early-stage disease.

"In the never-smoker with early-stage cancer, there were very few mutations in the genome, but when we looked at the whole transcriptome, we saw differences in gene expression," Whitsett said in a news release from the American Association for Cancer Research.

The never-smoker with late-stage disease had mutations in what Whitsett called "classic tumor-suppressor genes." It's possible that mutations of the tumor-suppressor genes may be a factor in late-stage lung cancer in never-smokers, the researchers said.

The tumors in both never-smokers lacked alterations in common genes associated with lung cancer, such as EGFR, KRAS and EML/ALK translocations. This suggests that these patients are ideal cases for the discovery of new mutations associated with lung adenocarcinomas in never-smokers, according to Whitsett and colleagues.

The study was slated for presentation Monday at an AACR/International Association for the Study of Lung Cancer joint conference on lung cancer, held in San Diego.

"This is the starting point. We certainly have a lot of pathways and gene expression alterations that we're going to be very interested in confirming and looking at in larger cohorts of patients," Whitsett said.

He and his colleagues are now validating these findings in a larger group of never-smokers and smokers with lung adenocarcinoma.

Because the current study was presented at a medical meeting, the data and conclusions should be viewed as preliminary until published in a peer-reviewed journal.

More information

The American Cancer Society has more about lung cancer in nonsmokers.

-- Robert Preidt

SOURCE: American Association for Cancer Research, news release, Jan. 9, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Look at Genomes of Nonsmokers With Lung Cancer
(Date:12/8/2016)... FL (PRWEB) , ... December 08, 2016 , ... ... awarded accreditation with distinction by the Undersea and Hyperbaric Medical Society (UHMS), the ... with advanced care and patient safety. Only a few hospitals and facilities have ...
(Date:12/8/2016)... ... December 08, 2016 , ... ZyDoc , a ... and Conventional Data Capture Methods for Input to Electronic Health Records: A Comparative ... of the comparative usability study demonstrate that a dictation-based method (“NLP Entry”) using ...
(Date:12/8/2016)... ... December 08, 2016 , ... CURE Media Group, the nation’s leading ... has aligned with Upstage Lung Cancer in efforts to combat lung cancer, announced CURE ... Hennessy, Jr said, “CURE Media Group is honored to team up with Upstage Lung ...
(Date:12/8/2016)... ... ... Premier Fitness Camp (PFC) and The Chopra Center for Wellbeing announced today the ... their world headquarters of Omni La Costa Resort & Spa in San Diego. , ... loss, personal development, a healthy lifestyle, or mental and physical healing. The week-long wellness ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... solutions for drugs, biologics and consumer health products, today announced that it had ... in 2006 as a non-profit organization to unite pharmaceutical and healthcare companies that ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... , Dec 9, 2016 Research and Markets ... 2016-2020" report to their offering. ... The global travel vaccines market to grow ... The report covers the present scenario and the growth prospects of ... size, the report considers the revenue generated from the sales of ...
(Date:12/8/2016)... Dec. 8, 2016 Australia Ophthalmic Lasers Market ... "Australia Ophthalmic Lasers Market Outlook to 2022", provides key ... report provides value, in millions of US dollars, volume ... - Excimer Lasers, Femtosecond Lasers and YAG Lasers. ... data for each of these market segements, and global ...
(Date:12/8/2016)... KEY FINDINGS The global medical ... Various reasons for growth of the medical lifting sling ... chronic diseases, high recovery cost of injuries and government ... lifting sling refers to an assistive device that helps ... connect to the lift and hold the patient. It ...
Breaking Medicine Technology: