Navigation Links
Researchers Identify Novel Mechanism That Make Cancer Tumors Grow
Date:2/10/2009

Scientists at the Institute for Myeloma and Bone Cancer Research (IMBCR) have uncovered a new pathway that could explain how blood vessels form within tumors.

LOS ANGELES, Feb. 10 /PRNewswire-USNewswire/ -- IMBCR researchers uncovered a new way that cancers orchestrate the production of their own blood supply. Recent studies have shown that many tumors make a protein called pleiotrophin (PTN). They now show that PTN produced by tumor cells in multiple myeloma, a common form of bone marrow-based cancer, changes white cells in the blood called "monocytes" into cells that form the lining of blood vessels called "vascular endothelial cells" (VEC). These VEC cells then become incorporated into the blood vessels that form within tumors.

"This is exciting news, and we feel this will not only have a tremendous impact on hematological tumors, such as myeloma, but other cancers as well," said James R. Berenson, M.D., Medical and Scientific Director of the IMBCR. "By uncovering this unique mechanism, how PTN produced by cancers actually changes circulating white cells into cells that line blood vessels that feed the tumor, we can direct our efforts to create more targeted approaches to eliminate blood supplies for cancers which should dramatically improve therapies for many types of cancers."

Haiming Chen, M.D., Ph.D. is the first author of the research, published this week on the cover of BLOOD. Drs. Berenson and Chen collaborated with scientists at Hemaquest, the Scripps Research Institute, Department of Molecular and Experimental Medicine and Cell Biology at Cedars-Sinai Medical Center, Departments of Neurosurgery, Pathology, and Microbiology, Immunology and Molecular Genetics at the David Geffen School of Medicine at the University of California at Los Angeles.

Part of IMBCR's multi-year research project, "Cure Myeloma Project," this research was funded by grants from th
'/>"/>

SOURCE Institute for Myeloma and Bone Cancer Research
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... Dan E. Chambers, an experienced Los Angeles criminal ... recently spoke on the radio to give his insights into ... Independent Journal Review radio show “The Right Mics” chose Chambers ... and now as a criminal defense attorney would provide him ... and sentencing of this high-profile case. , During the ...
(Date:3/3/2015)... The report “Alopecia – Pipeline Review, H1 2015? ... Alopecia is the loss of hair. Alopecia areata and ... Causes for alopecia include aging, genetics, illness, chemotherapy, malnutrition ... pattern hair loss, female diffuse hair loss, hairs easily ... focal or diffuse and by the presence or absence ...
(Date:3/3/2015)... Houston, TX (PRWEB) March 03, 2015 ... sponsored by the National Sleep Foundation. The event brings ... the world over. , According to the ... ongoing sleep problems of one form or another. Too ... a greater risk of physical illness and depression, and ...
(Date:3/3/2015)... The combinatorial, multi-gene GeneSight test has ... for patients with depression, and their use of ... genes that comprise the test, according to a ... and Assurex Health, and published online by The ... of the GeneSight Psychotropic test is based on ...
(Date:3/3/2015)... 03, 2015 The North ... to grow from $1,224.6 million to $1,694.6 ... 2014 and 2019. , Browse through the ... market for an analysis of industry trends ... tables and figures., http://www.micromarketmonitor.com/market/north-america-application-delivery-network-adn-7381582251.html , ...
Breaking Medicine News(10 mins):Health News:Dan E. Chambers Gives Radio Interview Providing Insights into American Sniper Guilty Verdict 2Health News:Dan E. Chambers Gives Radio Interview Providing Insights into American Sniper Guilty Verdict 3Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 2Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 3Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 4Health News:Medicationdiscountcard.com recognizes sleep awareness week with discounts on sleep meds including Ambien, Lunesta, and Sonata 2Health News:Medicationdiscountcard.com recognizes sleep awareness week with discounts on sleep meds including Ambien, Lunesta, and Sonata 3Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 2Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 3Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 4Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 5Health News:GeneSight Multi-Gene Combinatorial Pharmacogenomic (CPGx™) Test is More Predictive of Antidepressant Response than Single Gene Tests 6Health News:The North American Application Delivery Network Market is Estimated to Reach $1,694.6 Million in 2019- A Report By MicroMarket Monitor 2Health News:The North American Application Delivery Network Market is Estimated to Reach $1,694.6 Million in 2019- A Report By MicroMarket Monitor 3
... 21 countries, reserachers have found that blood pressure levels across ... not go down in all of the populations, but it ... led the World Health Organization MONICA study conducted between 1980s ... did appear to have a cross- population effect. Most importantly, ...
... overseas-trained doctor, Farid Zaer, who has registered himself as ... Queensland, to continue his medical practice.// The doctor has ... accused for wrong diagnosis involving nearly 208 patients. ... as a GP, without any restriction or supervision. Under ...
... African American children deteriorate as they progress through puberty, ... of Alberta//. The levels of insulin, however, remain unchanged ... phase of growth plays a crucial role in determining ... 7-year, Alabama based study was conducted by Dr. Geoff ...
... to tackle the global threat from bird flu, it ... is felt that// it may provide the best help ... up such a system has been published in the ... through co-ordination between such international labs can warn the ...
... pregnancy can reduce the incidence of pregnancy complications, ... by American Journal of Obstetrics and Gynecology. ... blood pressure and proteinuria (high levels of protein ... and legs is usually seen. If left unattended, ...
... In an attempt to spread awareness about AIDS/HIV, the ... the State organized a health awareness program// ('One step ... targeted specifically at barbers. ,The local barbers, ... rally. A special AIDS/HIV awareness session was conducted at ...
Cached Medicine News:Health News:Doctor Accused Of Misdiagnosing 208 Patients: Further Investigation Ordered 2Health News:African American Children More Pone to Develop Diabetes 2
(Date:3/3/2015)... March 3, 2015   ... 240 patients respectively Publications in peer reviewed ... Clinical Gastroenterology highlight diagnostic value of confocal laser ... China and across Asia ... (Euronext: MKEA, FR0010609263), inventor of Cellvizio®, the multidisciplinary confocal ...
(Date:3/3/2015)... and Markets ( http://www.researchandmarkets.com/research/x5lz9r/global_poc ) has announced ... 2015-2019" report to their offering. , ... to grow at a CAGR of 8.47 percent over ... IVD devices and tools used for diagnosing diseases in ... these devices helps in the rapid diagnosis of the ...
(Date:3/3/2015)... WAYNE, N.J. , March 3, 2015 ... USA announced today a new, integrated ... new portable solution is now available with a larger ... integrated console mounted system offers a larger viewing area ... console now provides additional space for accessories and storage, ...
Breaking Medicine Technology:Two New Publications From Leading Team in China Present Data From Large Clinical Trials Highlighting Advantages of Cellvizio in Diagnosis of Gastric and Esophageal Cancers 2Two New Publications From Leading Team in China Present Data From Large Clinical Trials Highlighting Advantages of Cellvizio in Diagnosis of Gastric and Esophageal Cancers 3Two New Publications From Leading Team in China Present Data From Large Clinical Trials Highlighting Advantages of Cellvizio in Diagnosis of Gastric and Esophageal Cancers 4Global POC Diagnostics Market 2015-2019 with Abbott Labs, Alere, Bayer Healthcare, Danaher, F. Hoffmann-La Roche & Johnson & Johnson Dominating 2Konica Minolta Medical Imaging and Shimadzu Medical Systems USA Introduce MobileArt Evolution EFX AeroDR-i with 17" Touch Monitor to Simplify Operation 2Konica Minolta Medical Imaging and Shimadzu Medical Systems USA Introduce MobileArt Evolution EFX AeroDR-i with 17" Touch Monitor to Simplify Operation 3
... Safety and Reduce Health Care CostsBETHESDA, Md., May 7 ... pilot program, contributing data on adverse events associated with ... will be possible to identify best practices that can ... overall costs to the health care system.This pilot hemovigilance ...
... Society Annual Meeting-BALTIMORE, May 7 Arcion Therapeutics, ... that develops pain therapies, today announced the presentation ... significantly reduced pain caused by diabetic neuropathy in ... presented in a poster session on May 8th ...
Cached Medicine Technology:National Hemovigilance Pilot Program Launches to Track Adverse Events Associated with Blood Transfusion 2National Hemovigilance Pilot Program Launches to Track Adverse Events Associated with Blood Transfusion 3Arcion Therapeutics' Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy 2Arcion Therapeutics' Topical Pain Candidate, ARC-4558, Significantly Reduces Pain Caused by Diabetic Neuropathy 3
... Test is a rapid in vitro qualitative test ... Virus Type 1 in human whole blood, serum ... by trained personnel in medical facilities, clinical laboratories, ... screening assay capable of providing test results in ...
The Clearblue Easy Digital Ovulation Test detects the surge of "luteinizing hormone in your urine, which usually happens 24 to 36 hours before you ovulate (release an egg). That means youll know the...
... BD Vacutainer® Safety-Lok™ Blood Collection Sets ... without compromising personal safety. The BD ... needles that can be shielded with ... for blood collection and infusion procedures. ...
Simplicity and multi-directional retraction for a broad range of abdominal procedures...
Medicine Products: