Navigation Links
Researchers Identify New Genetic Links to Psoriasis

Discovery of biological pathways could lead to treatments for other autoimmune diseases

FRIDAY, April 11 (HealthDay News) -- Researchers have discovered seven common DNA variations that increase the risk of a person developing psoriasis, one of which links the skin condition and psoriatic arthritis to other autoimmune disorders.

The findings, published April 4 in the open-access journal PLoS Genetics, may help define some of biological pathways that cause psoriasis and aid in the development of treatments that target these specific avenues.

"Common diseases like psoriasis are incredibly complex at the genetic level," lead investigator Anne Bowcock, a professor of genetics at the Washington University School of Medicine in St. Louis, said in a prepared statement. "Our research shows that small but common DNA differences are important in the development of psoriasis. Although each variation makes only a small contribution to the disease, patients usually have a number of different genetic variations that increases their risk of psoriasis and psoriatic arthritis."

Psoriasis, in which the body's immune cells mistakenly attack the skin, is characterized by red, scaly patches that can be itchy, painful or both. The autoimmune disease affects an estimated 7 million Americans. Up to 30 percent of sufferers may also develop psoriatic arthritis, an often excruciatingly painful and debilitating condition.

For the study, the researchers looked at common variations in the DNA genome called single nucleotide polymorphisms (SNPs). About 10 million SNPs affect the genome to make each individual unique. Some SNPs also affects a person's predisposition to disease or good health.

The investigators scanned more than 300,000 SNPs in the genomes of 223 psoriasis patients, including 91 who had psoriatic arthritis, and compared them to those found in 519 healthy control patients.

Researchers found seven unique DNA variations linked to psoriasis. Several found on chromosome 4 were strongly linked to psoriatic arthritis. These same variations were also associated with psoriasis and had been previously linked to type 1 diabetes, rheumatoid arthritis, Grave's disease (caused by an overactive thyroid gland) and celiac disease (caused by the inability to digest gluten).

A larger genome-wide association study of psoriasis patients is under way, and Bowcock said she expects it to find more genetic variations linked to the condition.

More information

The U.S. National Library of Medicine has more about psoriasis.

-- Kevin McKeever

SOURCE: Public Library of Science, news release, April 3, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
(Date:11/25/2015)... ... November 25, 2015 , ... As ... Water For Empowerment ™ attracts volunteers together who want to combine talents and ... as key stakeholders in the process. The non-profit launched its first major fundraiser ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dr. John Pierce, Medical Director at the Ageless ... treatment with the Capillus272™ Pro laser therapy cap. FDA cleared for safety and efficacy, ... without the need for surgery, prescription pills, or topical foams. , “Capillus272™ Pro ...
(Date:11/25/2015)... ... November 25, 2015 , ... Lakeview Health, a Jacksonville-based drug ... their sobriety and show through pictures what a positive difference it makes. The ... with the hashtag #FacesOfGratitude on their Facebook, Twitter, and Instagram accounts. Short ...
(Date:11/25/2015)... ... ... On November 23rd 2015 Cozy Products, a division of Bird-X ... Products explains what this means for business moving forward. , The Tri Lite heater ... model: to sell personal heaters that reduce energy consumption, are economical and keep people ...
(Date:11/25/2015)... ... 2015 , ... In an ongoing Clinical Study conducted by an independent physician, ... Angel is evaluating the efficacy of its product and its disinfection protocol. This study ... from May 2014 through October 2015 at a 360-bed, acute-care, academic medical center located ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015  Today AVACEN Medical announced the issue of United ... Energy Including Blood Viscosity Adjustment ". This patent shields the company,s AVACEN 100 dry heat therapy ... Method. Photo - ... ... ...
(Date:11/25/2015)... Endo International plc (NASDAQ: ENDP ) (TSX: ENL) today ... will discuss corporate updates at the 27 th Annual ... on Wednesday, December 2, 2015 at 1 p.m. ET. ... then the link to the event. Participants should allow approximately ... the site and download any streaming media software needed to ...
(Date:11/25/2015)... NEW YORK , November 25, 2015 ... global market of self-monitoring blood glucose devices was valued ... to grow with a CAGR of 5.7% during 2015 ... increasing geriatric population and increasing prevalence of diabetes. In ... about diabetes care is also contributing to the growth ...
Breaking Medicine Technology: