Navigation Links
Researchers Identify New Genetic Links to Psoriasis
Date:4/11/2008

Discovery of biological pathways could lead to treatments for other autoimmune diseases

FRIDAY, April 11 (HealthDay News) -- Researchers have discovered seven common DNA variations that increase the risk of a person developing psoriasis, one of which links the skin condition and psoriatic arthritis to other autoimmune disorders.

The findings, published April 4 in the open-access journal PLoS Genetics, may help define some of biological pathways that cause psoriasis and aid in the development of treatments that target these specific avenues.

"Common diseases like psoriasis are incredibly complex at the genetic level," lead investigator Anne Bowcock, a professor of genetics at the Washington University School of Medicine in St. Louis, said in a prepared statement. "Our research shows that small but common DNA differences are important in the development of psoriasis. Although each variation makes only a small contribution to the disease, patients usually have a number of different genetic variations that increases their risk of psoriasis and psoriatic arthritis."

Psoriasis, in which the body's immune cells mistakenly attack the skin, is characterized by red, scaly patches that can be itchy, painful or both. The autoimmune disease affects an estimated 7 million Americans. Up to 30 percent of sufferers may also develop psoriatic arthritis, an often excruciatingly painful and debilitating condition.

For the study, the researchers looked at common variations in the DNA genome called single nucleotide polymorphisms (SNPs). About 10 million SNPs affect the genome to make each individual unique. Some SNPs also affects a person's predisposition to disease or good health.

The investigators scanned more than 300,000 SNPs in the genomes of 223 psoriasis patients, including 91 who had psoriatic arthritis, and compared them to those found in 519 healthy control patients.

Researchers found seven unique DNA variations linked to psoriasis. Several found on chromosome 4 were strongly linked to psoriatic arthritis. These same variations were also associated with psoriasis and had been previously linked to type 1 diabetes, rheumatoid arthritis, Grave's disease (caused by an overactive thyroid gland) and celiac disease (caused by the inability to digest gluten).

A larger genome-wide association study of psoriasis patients is under way, and Bowcock said she expects it to find more genetic variations linked to the condition.

More information

The U.S. National Library of Medicine has more about psoriasis.



-- Kevin McKeever



SOURCE: Public Library of Science, news release, April 3, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... The Visiting ... Day Market. Featuring a collection of specialty vendors and unique items from across the ... and quality-focused health and wellness services offered by the VNA. The boutique will ...
(Date:10/13/2017)... ... October 13, 2017 , ... Coveros, a leader in ... awarded a contract by the Center for Medicare and Medicaid Services (CMS). The ... enterprise use of Agile methodologies in a consistent and high value manner across ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the ... to develop to enable prevention of a major side effect of chemotherapy in ... in pediatric patients. For cisplatin, hearing loss is FDA listed on-label as a ...
(Date:10/12/2017)... ... October 12, 2017 , ... Women-owned and Grand ... Best and Brightest in Wellness® by Best and Brightest. OnSite Wellness will be ... Oct. 20 from 7:30 a.m. to 2 p.m. at the Henry Autograph Collection ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... , Oct. 4, 2017 ... single-use, self-contained, illuminating medical devices, today announced regulatory ... Health Surveillance Agency (or Agência Nacional de Vigilância ... first single-use, cordless surgical retractor with integrated LED ... optimal access, illumination and exposure of a tissue ...
(Date:10/2/2017)... The Rebound mobile app is poised to become a vital ... prescription drug addiction. The app empowers users to develop an ... their dosage in a safe, controlled manner while maximizing well-being. ... 100,000 people to sign up will enjoy 3 months of ... ...
(Date:9/25/2017)... --  Montrium , an industry leader in powerful ... Trial Master Files & Inspection Readiness Conference ( ... Services has selected eTMF Connect to ... a leading European contract research organization (CRO), will ... enable greater collaboration with sponsors, improve compliance and ...
Breaking Medicine Technology: