Navigation Links
Researchers Identify New Genes Linked to the Origins of Alzheimer’s, Says Cure Alzheimer's Fund

Boston (PRWEB) June 24, 2013

Research uncovering 12, new gene variations connected to the cause of the early-onset familial form of Alzheimer’s disease (EO-FAD), which generally strikes before the age of 65, is being published in the journal Molecular Psychiatry.

The Cure Alzheimer’s Fund-supported research conducted a comprehensive genome-wide screen of over 100 EO-FAD families, identifying copy number variations (CNVs) in early onset families where the three genes and their mutations known to cause EO-FAD were not found. CNVs consist of abnormal deletions, duplications, or rearrangements of large sections of human genome DNA, and are known to make a significant contribution to genetic variation.

“Every new gene or gene mutation found related to Alzheimer’s pathology provides new targets for intervention in the pathology — new ways to stop the disease,” said the project’s lead researcher Dr. Rudolph Tanzi of Massachusetts General Hospital, Harvard Medical School and Chair of the Cure Alzheimer’s Fund’s Research Consortium. “Part of the reason why so many Alzheimer’s drugs have failed is that we in the research field have not understood enough about the origins of the disease to develop interventions that are both safe and effective. By learning more about the very complex genetic underpinnings of the disease — what genes affect risk or protection for the disease, and what functions they perform, and how they contribute to the pathology — we have a much better chance to stop the disease quicker.”

Prior to Tanzi’s latest research, only one CNV had been linked to Alzheimer’s disease through his research and co-discovery completed in the 1980’s and 90’s of mutations in three genes — amyloid precursor protein (APP), presenilin 1 and 2 (PSEN1 and PSEN2) that cause roughly 50 percent of EO-FAD.

Lead author, Raj Hooli, an Instructor in Neurology at MGH and Harvard, said “These are the first EO-FAD gene mutations to be described since the presenilin genes in 1995. Our hope is to use these as we did the original EO-FAD genes to accelerate novel therapies that can prevent and treat Alzheimer’s disease.”

About Cure Alzheimer’s Fund

The Cure Alzheimer’s Fund is governed by a board of directors; administered by a small, full-time staff; and guided scientifically by a Research Consortium and Scientific Advisory Board, which includes a Nobel Laureate. Cure Alzheimer's Fund™ is a 501(c)(3) public charity. Cure Alzheimer’s Fund has supported 77 projects in 45 laboratories of leading Alzheimer’s researchers in the United States and abroad.

Read the full story at

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... Fla. (PRWEB) , ... June 24, 2016 , ... Global ... Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition ... Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this year’s ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway ... call for a minimum wage raise to $12 an hour by 2020 and then adjusting ... restore the lost value of the minimum wage, assure the wage floor does not erode ...
(Date:6/24/2016)... New York, NY (PRWEB) , ... June 24, ... ... lifestyle publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as ... believes that “the most beautiful women in the world, and the most handsome ...
(Date:6/24/2016)... ... , ... National recruitment firm Slone Partners is pleased to announce ... experience, as Vice President of North American Capital Sales at HTG Molecular . ... sales team in the commercialization of the HTG EdgeSeq system and associated reagents in ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  MedSource announced today ... its e-clinical software solution of choice.  This latest ... possible value to their clients by offering a ... preferred relationship establishes nowEDC as the EDC platform ... MedSource,s full-service clients.  "nowEDC has long been a ...
(Date:6/23/2016)... 23, 2016  In a startling report released today, National ... by lacking a comprehensive, proven plan to eliminate prescription opioid overdoses. ... of how states are tackling the worst drug crisis in recorded ... – Kentucky , New Mexico ... . Of the 28 failing states, three – Michigan ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
Breaking Medicine Technology: