Navigation Links
Researchers Identify New Genes Linked to the Origins of Alzheimer’s, Says Cure Alzheimer's Fund
Date:6/24/2013

Boston (PRWEB) June 24, 2013

Research uncovering 12, new gene variations connected to the cause of the early-onset familial form of Alzheimer’s disease (EO-FAD), which generally strikes before the age of 65, is being published in the journal Molecular Psychiatry.

The Cure Alzheimer’s Fund-supported research conducted a comprehensive genome-wide screen of over 100 EO-FAD families, identifying copy number variations (CNVs) in early onset families where the three genes and their mutations known to cause EO-FAD were not found. CNVs consist of abnormal deletions, duplications, or rearrangements of large sections of human genome DNA, and are known to make a significant contribution to genetic variation.

“Every new gene or gene mutation found related to Alzheimer’s pathology provides new targets for intervention in the pathology — new ways to stop the disease,” said the project’s lead researcher Dr. Rudolph Tanzi of Massachusetts General Hospital, Harvard Medical School and Chair of the Cure Alzheimer’s Fund’s Research Consortium. “Part of the reason why so many Alzheimer’s drugs have failed is that we in the research field have not understood enough about the origins of the disease to develop interventions that are both safe and effective. By learning more about the very complex genetic underpinnings of the disease — what genes affect risk or protection for the disease, and what functions they perform, and how they contribute to the pathology — we have a much better chance to stop the disease quicker.”

Prior to Tanzi’s latest research, only one CNV had been linked to Alzheimer’s disease through his research and co-discovery completed in the 1980’s and 90’s of mutations in three genes — amyloid precursor protein (APP), presenilin 1 and 2 (PSEN1 and PSEN2) that cause roughly 50 percent of EO-FAD.

Lead author, Raj Hooli, an Instructor in Neurology at MGH and Harvard, said “These are the first EO-FAD gene mutations to be described since the presenilin genes in 1995. Our hope is to use these as we did the original EO-FAD genes to accelerate novel therapies that can prevent and treat Alzheimer’s disease.”

About Cure Alzheimer’s Fund

The Cure Alzheimer’s Fund is governed by a board of directors; administered by a small, full-time staff; and guided scientifically by a Research Consortium and Scientific Advisory Board, which includes a Nobel Laureate. Cure Alzheimer's Fund™ is a 501(c)(3) public charity. Cure Alzheimer’s Fund has supported 77 projects in 45 laboratories of leading Alzheimer’s researchers in the United States and abroad.

Read the full story at http://www.prweb.com/releases/2013/6/prweb10847001.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. NIH awards $20 million over 5 years to train next generation of global health researchers
2. Researchers develop a new cell and animal model of inflammatory breast cancer
3. Researchers uncover a viable way for colorectal cancer patients to overcome drug resistance
4. Researchers Find Gene Mutations That May Be a Key to Autism
5. Researchers find evidence of banned antibiotics in poultry products
6. NJ stroke researchers report advances in spatial neglect research at AAN Conference
7. Autism by the numbers: Yale researchers examine impact of new diagnostic criteria
8. Researchers Map Brain Regions Linked to Intelligence
9. Researchers ID Genes That May Determine Mental Illness
10. Researchers Develop Blood Test for Depression
11. University of Cincinnati researchers win $3.7M grant from US Department of Defense
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s a ... the bar too high can result in disappointment, perhaps even self-loathing. However, those who ... , Research from PsychTests.com reveals that behind the tendency to set ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events ... turn to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. ... tools for healthy coping following a traumatic event. , Trauma sufferers tend to feel ...
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is ... Road To Recovery® program to drive cancer patients to and from their cancer treatments. ... the highest quality of life and ongoing independence. Getting to and from medical ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... HILL, N.C. , June 24, 2016 /PRNewswire/ ... healthcare decisions and regulators/payers have placed more emphasis ... new environment, patient support programs in the pharmaceutical ... for patients, medications. Consequently, pharmaceutical companies are focusing ... ensure they are providing products and services that ...
(Date:6/24/2016)... FRANCISCO, Calif. , June 24, 2016 /PRNewswire/ ... ), a biopharmaceutical company developing novel therapeutics for ... unmet needs, today announced the closing of its ... of common stock, at the public offering price ... in the offering were offered by GBT. GBT ...
(Date:6/24/2016)... , June 24, 2016 ... Markets has announced the addition of the " ... offering. This ... and provides an updated review, including its applications in ... the total market, which includes three main industries: pharmaceutical ...
Breaking Medicine Technology: