Navigation Links
Researchers Identify 2 Genes Linked to Fatty Liver Disease
Date:3/24/2010

Could yield better tests, treatments for condition that can cause liver damage, type 2 diabetes

WEDNESDAY, March 24 (HealthDay News) -- Researchers have identified two gene variants that increase the risk of both the most common chronic liver disease in the United States as well as type 2 diabetes.

People who carry the variants of a gene for apolipoprotein C3 (APOC3), which produces an enzyme important in fat metabolism, have a higher incidence of nonalcoholic fatty liver disease and also insulin resistance, according to a report in the March 25 issue of the New England Journal of Medicine. The research group was led by Dr. Gerald I. Shulman, a professor of physiological chemistry, medicine and cellular and molecular physiology at Yale University.

Identification of the gene variants "might make it possible to screen individuals to see if they have a higher risk of fatty liver disease," Shulman said. "It also can provide an ideal drug target to prevent development of fatty liver disease and insulin resistance."

Fatty liver disease can be caused by excessive alcoholic consumption and obesity. Its incidence has increased in the United States, and more than 30 percent of Americans are estimated to have it, Shulman said.

In many cases, excess buildup of fat in the liver causes only minor problems. But it can progress to cause major, life-threatening deterioration of liver function. In the same way, insulin resistance can lead to type 2 diabetes, a major risk factor for heart attack, stroke and other cardiovascular problems.

Shulman and his colleagues first looked for the APOC3 gene variants in 95 lean Asian Indian men, an ethnic group in which the incidence of fatty liver disease is high, for unknown reasons. "Carriers of these gene variants had 5.5 percent fat in their liver, and were also markedly insulin-resistant," Shulman said.

The variants cause higher levels of APO3C, which in
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. NIA researchers find gene to explain mouse embryonic stem cell immortality
2. Researchers discover fundamental step in immune-system development
3. Scott & White Healthcare researchers studying investigational agent that targets breast cancer
4. SRI International Researchers to Present Work on Early Detection Tool for Neglected Tropical Diseases at 2010 American Chemical Society (ACS) Meeting
5. Researchers find new chemotherapy combination shows promise in endometrial cancer
6. Researchers ID brain abnormalities in children exposed to methamphetamine in utero
7. Mount Sinai researchers are the first to identify heart abnormalities in World Trade Center workers
8. Researchers discover chemical that may protect hearts of muscular dystrophy patients
9. Researchers recommend curriculum on unhealthy substance use
10. Using new approach, Mayo Clinic researchers find level of gene alters risk of Alzheimers disease
11. Researchers discover brain tumors grow-or-go switch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/26/2014)... 2014 Parker & Sons, Inc. ... in heating, cooling and plumbing contractor services throughout ... services in 2014 with regard to air-conditioning systems. ... is known for its incredibly hot summers. Working ... intricacies and details of a wide variety of ...
(Date:12/25/2014)... 2014 The click strand ... strength and durability. Today, the business announces a ... valid until Jan. 30, 2015. , Click strand ... hardwood. BambooFlooringChina.com is a well-known brand in the ... to find a reliable bamboo flooring supplier. , ...
(Date:12/25/2014)... 2014 Product liability lawsuits filed in ... ( http://www.consumerinjurylawyers.com/DePuy/ ) continue to move forward in federal ... issued in the U.S. District Court, Northern District of ... open conference on January 7, 2015, at the Paul ... West Palm Beach, Florida. The Conference is scheduled to ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company supplying ... of discounted prom dresses, most of which are priced ... the company, the promotion is valid until Jan. 22, ... the UK market. , The prom dresses in this ... styles: A-line strapless, empire strapless chiffon, one shoulder, floor-length, ...
(Date:12/25/2014)... sells many bamboo products and the business is famous ... announces big discounts on its bamboo mats , which ... the world’s leader in bamboo flooring. According to the ... 2015. , The bamboo mats are made from well-treated ... the bamboo strips for the mats are boiled and ...
Breaking Medicine News(10 mins):Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 2Health News:Parker & Sons Announces Record Demand For 24 Hour Emergency Services In 2014 With Regard To Air-Conditioning Systems 3Health News:BambooFlooringChina.com: click strand woven bamboo flooring promotion valid until Jan. 30, 2015. 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 2Health News:Federal Court Overseeing DePuy ASR Hip Lawsuit Set to Convene Conference in January, Bernstein Liebhard LLP Reports 3Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Various Styles of Bamboo Mats in Many Colors from BambooFlooringChina.com 2
... Chiltern, a leading global research,organization announced ... its,suite of clinical trial management applications providing ... collection and management of,electronic clinical trial data. ... DataLabs EDC system according to 21CRF Part ...
... Special Delivery Unit at The Children,s,Hospital of Philadelphia, ... diagnosed birth defects, PHILADELPHIA, June 22 ... Children,s Hospital of Philadelphia for,the 12th Annual Fetal ... have been followed by the Center for Fetal ...
... are calling on Louisiana Governor Jindal to veto a ... SB 312 was quietly,pushed through the legislature by PR ... are asking Jindal to use his veto in,the interest ... discussion,but they were not., Fluoride is added to ...
... (formerly,Diagnostic Ultrasound Corp.), the maker of BladderScan(R) bladder ... selection, for the second year in a row, ... in Washington State by Washington CEO Magazine., ... as the 4th "Best Company To Work For" ...
... Pa., June 20 The Department of,Agriculture is recommending ... Dairy farm in New Salem, York County, discard it ... Dennis Wolff said today., Raw milk is milk ... farms to sell raw milk, but requires they obtain,permits ...
... A recent study by Best,Practices, LLC found that ... Introduction team was one of the most important ... New Product Launch,Through Effective Processes and Authority Roles, ... optimize their launch governance groups and,maximize the success ...
Cached Medicine News:Health News:Chiltern Enhances Its Portfolio of Electronic Data Capture (EDC) Services With the Addition of Hosting and eCRF Design Services for DataLabs (by ClinPhone) and Medidata Rave(R) Certification 2Health News:12th Annual Fetal Surgery Family Reunion Gathers Families From Across the U.S. and Canada 2Health News:12th Annual Fetal Surgery Family Reunion Gathers Families From Across the U.S. and Canada 3Health News:Professionals Ask Governor Jindal to Veto Unfair Fluoridation Bill 2Health News:Verathon Inc., Recognized, Second Year Running, as Outstanding Workplace in Washington State by Washington CEO Magazine 2Health News:PA Agriculture Department Warns Consumers About Raw Milk Sold by York County Dairy 2Health News:Ensuring a Successful New Product Launch Through Effective Processes and Authority Roles 2
(Date:12/24/2014)... Dec. 23, 2014 ResMed (NYSE: RMD ... action against Chinese medical device manufacturer BMC Medical Co., Ltd. ... that BMC,s masks listed below infringe ResMed,s patents, and entered ... masks in the United States : ... mask , Willow nasal pillows mask , iVolve ...
(Date:12/24/2014)... 2014  The American Diabetes Association is recommending ... people with diabetes and that all people with ... statins, in keeping with recent changes to guidelines ... College of Cardiology (ACC) and American Heart Association ... recent changes to the Association,s annual revised Standards ...
(Date:12/22/2014)... , Dec. 22, 2014  CytoSorbents Corporation ... its CytoSorb® blood purification technology to help fight ... in 28 countries worldwide, today announced the appointment ... MD, FACS, as its Senior Vice President of ... Dr. Di Russo is an ...
Breaking Medicine Technology:ResMed Wins Patent Infringement Lawsuit Against Chinese Manufacturer BMC Medical 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 2New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 3New Standards of Care Provide Guidelines for Statin Use for People with Diabetes to Prevent Heart Disease 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 2CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 3CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 4CytoSorbents Appoints Dr. Gregory B. Di Russo as Senior Vice President of Clinical Development 5
... Feb. 15, 2012 CIVCO Medical Solutions is pleased ... Vice President of Sales and Marketing for its Multi-Modality ... of sales and marketing within MMI. "Robin has led ... and this appointment recognizes the outstanding contribution Robin has ...
... Feb.15, 2012  PuraMed BioScience®, Inc. (OTC Bulletin Board: ... healthcare products, announced today its financial results for the ... the publication of its quarterly 10Q SEC filing ... the three months ended December 31, 2011 of $608,676 ...
Cached Medicine Technology:CIVCO Promotes Robin Therme to Senior VP of Sales & Marketing, Multi-Modality Imaging 2PuraMed BioScience®, Inc. Reports Increased Revenue From Sales of LipiGesic® M, Its Flagship Migraine Pain Relief Product 2PuraMed BioScience®, Inc. Reports Increased Revenue From Sales of LipiGesic® M, Its Flagship Migraine Pain Relief Product 3
... BD Edgeahead Stiletto / MVR knife. 1.1 mm ... of 1.1 mm (19G) Cannula (5/bx, 1 bx/ca). ... are consistently sharp and precise. Sure grip handles ... Tapered tip creates a fluid tight incision for ...
Lens Plus Daily Cleaner is the preservative-free daily cleaner for soft contact lenses....
... is the most convenient multi-purpose no rub ... bottle without the need to rub: cleans, ... removes protein build-up when used daily. Its ... a special ingredient that removes protein deposits ...
For use in cleaning soft contact lenses. Sensitive Eyes daily cleaner loosens and removes accumulations of film, deposits, and debris from soft contact lenses. Use with heat, chemical, and hydrogen p...
Medicine Products: