Navigation Links
Researchers Identify 2 Genes Linked to Fatty Liver Disease
Date:3/24/2010

Could yield better tests, treatments for condition that can cause liver damage, type 2 diabetes

WEDNESDAY, March 24 (HealthDay News) -- Researchers have identified two gene variants that increase the risk of both the most common chronic liver disease in the United States as well as type 2 diabetes.

People who carry the variants of a gene for apolipoprotein C3 (APOC3), which produces an enzyme important in fat metabolism, have a higher incidence of nonalcoholic fatty liver disease and also insulin resistance, according to a report in the March 25 issue of the New England Journal of Medicine. The research group was led by Dr. Gerald I. Shulman, a professor of physiological chemistry, medicine and cellular and molecular physiology at Yale University.

Identification of the gene variants "might make it possible to screen individuals to see if they have a higher risk of fatty liver disease," Shulman said. "It also can provide an ideal drug target to prevent development of fatty liver disease and insulin resistance."

Fatty liver disease can be caused by excessive alcoholic consumption and obesity. Its incidence has increased in the United States, and more than 30 percent of Americans are estimated to have it, Shulman said.

In many cases, excess buildup of fat in the liver causes only minor problems. But it can progress to cause major, life-threatening deterioration of liver function. In the same way, insulin resistance can lead to type 2 diabetes, a major risk factor for heart attack, stroke and other cardiovascular problems.

Shulman and his colleagues first looked for the APOC3 gene variants in 95 lean Asian Indian men, an ethnic group in which the incidence of fatty liver disease is high, for unknown reasons. "Carriers of these gene variants had 5.5 percent fat in their liver, and were also markedly insulin-resistant," Shulman said.

The variants cause higher levels of APO3C, which in
'/>"/>

Copyright©2010 ScoutNews,LLC.
All rights reserved

Page: 1 2 3

Related medicine news :

1. NIA researchers find gene to explain mouse embryonic stem cell immortality
2. Researchers discover fundamental step in immune-system development
3. Scott & White Healthcare researchers studying investigational agent that targets breast cancer
4. SRI International Researchers to Present Work on Early Detection Tool for Neglected Tropical Diseases at 2010 American Chemical Society (ACS) Meeting
5. Researchers find new chemotherapy combination shows promise in endometrial cancer
6. Researchers ID brain abnormalities in children exposed to methamphetamine in utero
7. Mount Sinai researchers are the first to identify heart abnormalities in World Trade Center workers
8. Researchers discover chemical that may protect hearts of muscular dystrophy patients
9. Researchers recommend curriculum on unhealthy substance use
10. Using new approach, Mayo Clinic researchers find level of gene alters risk of Alzheimers disease
11. Researchers discover brain tumors grow-or-go switch
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... It is better to give than to receive at ... new study suggests. , The study found that 15- and ... their money to family members, are less likely to become ... risks or keeping the money for themselves. , The researchers ... Academy of Sciences . , The study focused on the ...
(Date:4/24/2014)... National Science Foundation has awarded LSU Health Sciences ... (REU) Site grant in the amount of $295,635. ... from diverse social and educational backgrounds, underrepresented in ... The project will provide students with training ... It will be led by Principal Investigator ...
(Date:4/23/2014)... frozen stool from healthy, unrelated donors was safe ... diarrhea caused by Clostridium difficile , according ... Clinical Infectious Diseases and available online. Known ... effective whether given via a colonoscope or a ... make this promising treatment more readily available to ...
(Date:4/23/2014)... director at the National Institute of Arthritis and Musculoskeletal ... recipient of the Ross Prize in Molecular Medicine, conferred ... Medicine . The award will be given on June ... Manhattan, followed by scientific presentations by Dr. O,Shea and ... Institutes of Health. , The award, which includes a ...
(Date:4/23/2014)... have developed a way to detect and measure cancer ... particles with tails of synthetic DNA., A team led ... used gold nanoparticles to target and bind to fragments ... variants, which can indicate the presence and stage of ... in a cell can be determined by examining the ...
Breaking Medicine News(10 mins):Health News:Study: Altruistic adolescents less likely to become depressed 2Health News:Pilot study suggests ways to widen access to fecal transplants for C. diff infections 2Health News:NIH scientist to receive Ross Prize in Molecular Medicine 2Health News:Gold nanoparticles help target, quantify breast cancer segments in a living cell 2
... in the journal Annals of Neurology, says that radiation emitted ... is the first study to show that mobile phone affect ... ,Italian researchers found in the current study that ... brain closest to the phone when used for 45 minutes ...
... set of dietary guidelines. Apart from the dietary guidelines ... Dietary Guidelines, the revised Food Guide Pyramid and food ... ,All the guidelines though are given by different organizations ... by all are increased intake of fruit and vegetables, ...
... mosquito-transmitted viral fever//, has claimed two lives in Madhya ... officials said. ,The disease, which has been reported ... the state through villages in Betul district bordering Maharashtra, ... stooped posture to the victim as a result of ...
... symptom of Sj?gren’s (SHOW-grins) syndrome was found to be the ... periods. ,Typical signs and symptoms include dry, gritty ... causes difficulty swallowing, dental cavities and enlarged parotid glands. The ... and in front of your ears. Other signs and symptoms ...
... treatments has been accused of placing money before patients//, ... drug. <BR.,Patients suffering from cancer linked to asbestos will ... is pemetrexed disodium, after a study conducted ... ,The group analyzed the cost effectiveness of the ...
... is made easy but the new fat-busting laser treatment called SmartLipo. ... to be a quicker and less invasive form of liposuction//. It ... the double chins areas. About six cosmetic surgery clinics in ... treatment. ,But he Food and Drug Administration (FDA) has ...
Cached Medicine News:
(Date:1/15/2014)... , Jan. 15, 2014  Zafgen, Inc., a leading ... of severely obese patients, today announced initial results ... selective inhibitor of methionine aminopeptidase 2 (MetAP2), in ... of genetic obesity.  These results showed improvements in ...
(Date:1/14/2014)... 14, 2014 The Brandeis Medical Center, led by Dr. ... premier and affordable laser tattoo removal experience with the advanced Astanza ... in providing high quality cosmetic services with cutting edge medical technology ... Southern California has seen a dramatic increase in ...
(Date:1/14/2014)... 14, 2014 NineSigma , Inc., the leading ... Innovation Leadership Summit , May 14-16, 2014 at the ... Ohio . This is the ... to breakthrough achievements through open innovation. Participants will learn ...
Breaking Medicine Technology:Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4Beverly Hills Physician Features Tattoo Removal with the Astanza Duality Laser, Offers $99 Special 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... , FORT LAUDERDALE, Fla., Dec. 22 LifeSync ... purchased the Besson Patent Portfolio and other wireless vital ... the use of wireless, two-way, digital communication between patient-electrodes ... patient. The acquired patent portfolio includes additional wireless improvements ...
... , HULL, England and FT. SASKATCHEWAN, Canada, ... & Nephew plc (LSE: SN; NYSE: SNN ), ... substantially all of the assets of Nucryst Pharmaceuticals Corp. ("Nucryst") ... manufacturing assets from Nucryst,s Fort Saskatchewan, Canada operations and the ...
Cached Medicine Technology:Smith & Nephew Completes Acquisition of the Assets of Nucryst Pharmaceuticals Corp. 2Smith & Nephew Completes Acquisition of the Assets of Nucryst Pharmaceuticals Corp. 3
... offers an economical, ... alternative to existing ... guarantees accurate and ... the time-consuming recalibration ...
... 2000 is an ... for automated 96-/384-well ... With its ability ... any routine liquid ...
... Multidrop 384 offers lower consumption of ... screening applications. The Multidrop 384 is ... screening and microvolume dispensing into 384- ... outstanding flexibility. It can easily switch ...
RIA kit for the determination of blocking autoantibodies to the acetylcholine receptor (AChR) in serum...
Medicine Products: