Navigation Links
Researchers ID changes that may occur in neural circuits due to cocaine addiction
Date:5/14/2014

(NEW YORK May 14) A research team from the Friedman Brain Institute of the Icahn School of Medicine at Mount Sinai published evidence showing that subtle changes of inhibitory signaling in the reward pathway can change how animals respond to drugs such as cocaine. This is the first study to demonstrate the critical links between the levels of the trafficking protein, the potassium channels' effect on neuronal activity and a mouse's response to cocaine. Results from the study are published in the peer-reviewed journal Neuron earlier this month.

The authors investigated the role of sorting nexin 27 (SNX27), a PDZ-containing protein known to bind GIRK2c/GIRK3 channels, in regulating GIRK currents in dopamine (DA) neurons on the ventral tegmental area (VTA) in mice.

"Our results identified a pathway for regulating the excitability of the VTA DA neurons, highlighting SNX27 as a promising target for treating addiction," said Paul A. Slesinger, PhD, Professor, Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai. "Future research will focus on the role that potassium channels and trafficking proteins have in models of addiction."


'/>"/>

Contact: Sid Dinsay
newsmedia@mssm.edu
212-241-9200
The Mount Sinai Hospital / Mount Sinai School of Medicine
Source:Eurekalert

Page: 1

Related medicine news :

1. Researchers identify genetic marker linked to OCD
2. Mount Sinai researchers identify changes that may occur in neural circuits due to addiction
3. UTHealth CCTS Biobank continues to innovate allocation of resources for researchers
4. Three Nova Southeastern University researchers receive patents
5. Researchers use DNA to build tool that may literally shine light on cancer
6. Sleep researchers at SRI International identify promising new treatment for narcolepsy
7. Chimpanzees show similar personality traits to humans, Georgia State researchers say
8. Researchers present findings on promising biomarker for esophageal cancer
9. Bioinformatics approach helps researchers find new uses for old drug
10. BrightFocus honors 5 vision researchers
11. Researchers link age, general health and antidepressant use with eye disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/2/2016)... ... May 02, 2016 , ... Eating Recovery Center’s Insight Behavioral Health ... anxiety disorders, has rebranded its eating disorder program under a new name: Eating Recovery ... facility on May 16. , To celebrate, ERC Chicago will host a ribbon-cutting ...
(Date:5/2/2016)... , ... May 02, 2016 , ... ... Data Book for the 2016 Main Residency Match® (“the Match”), the system through ... United States teaching institutions. A record-high 30,750 positions were placed in the 2016 ...
(Date:5/2/2016)... ... May 02, 2016 , ... East Los Angeles dentist , ... can visit Dr. Assili to receive any dental extraction treatment for $40 off the ... June 30, 2016. With the lower price, patients can more easily afford extractions to ...
(Date:5/2/2016)... ... May 02, 2016 , ... ... new Specialty Pharmacy Patient Satisfaction Award that will recognize specialty pharmacies for their ... from Zitter Health Insights’ Specialty Pharmacy Patient Satisfaction Survey compiled throughout 2016. Results ...
(Date:5/2/2016)... PORT RICHEY, Fla. (PRWEB) , ... ... ... experts and medical researchers report that many commonly used prescription medications, including ... loss (1). To mitigate these risks, Novus Medical Detox Center —a ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... BERLIN , April 29, 2016 ... world-leading glyco-biology expertise, today announces the appointment of Dr. ... Dr. Zurlo is an oncologist with many years ... pharmaceutical and biotechnology industries. His last role was at ... Member of the Executive Board. Previously Dr. Zurlo held ...
(Date:4/28/2016)... , April 28, 2016  While Abbott,s ... complement the company,s valve repair and stent business, ... also places Abbott more firmly into patient monitoring.  ... the fastest growing device areas, with double-digit growth ... recent report,  Advanced Remote Patient Monitoring ...
(Date:4/28/2016)... April 28, 2016 ... George Phillips und Stephen Schmidt ... ArisGlobal®, ein führender Anbieter cloudbasierter ... heute bekannt, dass neue Führungskräfte zum Team ... sind, die vielfältige Erfahrungen mitbringen.  Dies wird ...
Breaking Medicine Technology: