Navigation Links
Researchers ID Suite of Genes in Aging Process
Date:11/19/2008

Biomarkers could provide scientific baseline for anti-aging drug trials, study says

WEDNESDAY, Nov. 19 (HealthDay News) -- Genetic biomarkers that are highly accurate in determining physiological age have been identified by researchers at California's Buck Institute for Age Research, who said it may be possible to use these biomarkers to test anti-aging drugs.

The study, which included nematode worms, microarrays that measure changes in gene expression, and complex computer algorithms, was published in the Nov. 20 online edition of Aging Cell.

Chronological age (time from birth) and physiological age (level of function) are rarely in sync, the researchers noted. It's easy to determine chronological age simply by counting forward from birth. But physiological age is more subjective. For example, some 70-year-old people function at the level of someone in their 50s, while other 70-year-olds seem prematurely aged. The same is true of the nematode worms used in the study.

The Buck Institute team conducted individual whole-genome profiles of 104 worms and correlated the results with age-related behavior and survival. The researchers identified a suite of genes actively involved in the aging process.

"This is the first evidence that physiological age can be predicted non-subjectively. This is a first step; our results were not perfect, but we were able to predict the ages of the animals 70 percent of the time, which is far better than anything that has been done before," study author Simon Melov said in a Buck Institute news release.

In humans, being able to examine aging-related biomarkers could help determine if a person is aging faster or slower than would normally be expected. In addition, examining such biomarkers over time would provide a scientific baseline for clinical trials of anti-aging drugs.

"I am optimistic that we will be able to pursue this line of research further," Melov said. "Research into the biology of aging in humans has been hampered by the lack of irrefutable biomarkers that correlate with the aging process. I am confident that at some point, there will be a non-subjective method of determining how old someone is with a high level of confidence."

More information

The U.S. Centers for Disease Control and Prevention discusses healthy aging for older adults.



-- Robert Preidt



SOURCE: Buck Institute for Age Research, news release, Nov. 19, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers: Ban on fast food TV advertising would reverse childhood obesity trends
2. Brigham and Womens Researchers Partner with Vocantas to use CallAssure in Clinical Research Study
3. Leeds researchers reshape the future of drug discovery
4. UNC researchers find clue to stopping breast-cancer metastasis
5. U of U researchers to use patients own stem cells to treat heart failure
6. Researchers identify toehold for HIVs assault on brain
7. Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage
8. Researchers Use New Method to Control Bleeding in Hemophilia
9. Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
10. Protein can nurture or devastate brain cells, depending on its friends, researchers find
11. Researchers find stem cells from monkey teeth can stimulate growth and generation of brain cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers ID Suite of Genes in Aging Process
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer ... one of the most popular and least understood books in the Holy Scriptures, Revelation. ... descriptions that have baffled scholars for centuries. Many have tossed it off as mere ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... MD (PRWEB) , ... October 12, 2017 , ... The ... of Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual ... – 8. , In honor of Morris F. Collen, a pioneer in the field ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... Leading ... their peers in Washington, D.C., for the 49th Congress of the International Society ... ., Vice President of the Center for Cancer and Blood Disorders at ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
(Date:9/28/2017)... Cohen Veterans Bioscience and Early Signal Foundation announce a ... sensors for real-time monitoring of patients with trauma-related and ... focused on disruptive health solutions for rare disorders and ... record and integrate behavioral, cognitive, physiological and contextual data. ... ...
(Date:9/23/2017)... HORSHAM, Pa. , Sept. 22, 2017 ... received a complete response letter from the U.S. Food ... (BLA) seeking approval of sirukumab for the treatment of ... response letter indicates additional clinical data are needed to ... of moderately to severely active RA. ...
Breaking Medicine Technology: