Navigation Links
Researchers ID Suite of Genes in Aging Process

Biomarkers could provide scientific baseline for anti-aging drug trials, study says

WEDNESDAY, Nov. 19 (HealthDay News) -- Genetic biomarkers that are highly accurate in determining physiological age have been identified by researchers at California's Buck Institute for Age Research, who said it may be possible to use these biomarkers to test anti-aging drugs.

The study, which included nematode worms, microarrays that measure changes in gene expression, and complex computer algorithms, was published in the Nov. 20 online edition of Aging Cell.

Chronological age (time from birth) and physiological age (level of function) are rarely in sync, the researchers noted. It's easy to determine chronological age simply by counting forward from birth. But physiological age is more subjective. For example, some 70-year-old people function at the level of someone in their 50s, while other 70-year-olds seem prematurely aged. The same is true of the nematode worms used in the study.

The Buck Institute team conducted individual whole-genome profiles of 104 worms and correlated the results with age-related behavior and survival. The researchers identified a suite of genes actively involved in the aging process.

"This is the first evidence that physiological age can be predicted non-subjectively. This is a first step; our results were not perfect, but we were able to predict the ages of the animals 70 percent of the time, which is far better than anything that has been done before," study author Simon Melov said in a Buck Institute news release.

In humans, being able to examine aging-related biomarkers could help determine if a person is aging faster or slower than would normally be expected. In addition, examining such biomarkers over time would provide a scientific baseline for clinical trials of anti-aging drugs.

"I am optimistic that we will be able to pursue this line of research further," Melov said. "Research into the biology of aging in humans has been hampered by the lack of irrefutable biomarkers that correlate with the aging process. I am confident that at some point, there will be a non-subjective method of determining how old someone is with a high level of confidence."

More information

The U.S. Centers for Disease Control and Prevention discusses healthy aging for older adults.

-- Robert Preidt

SOURCE: Buck Institute for Age Research, news release, Nov. 19, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers: Ban on fast food TV advertising would reverse childhood obesity trends
2. Brigham and Womens Researchers Partner with Vocantas to use CallAssure in Clinical Research Study
3. Leeds researchers reshape the future of drug discovery
4. UNC researchers find clue to stopping breast-cancer metastasis
5. U of U researchers to use patients own stem cells to treat heart failure
6. Researchers identify toehold for HIVs assault on brain
7. Researchers Tackle CLL, Diabetes and Trauma-Hemorrhage
8. Researchers Use New Method to Control Bleeding in Hemophilia
9. Stem cells with potential to regenerate injured liver tissue identified by Penn researchers
10. Protein can nurture or devastate brain cells, depending on its friends, researchers find
11. Researchers find stem cells from monkey teeth can stimulate growth and generation of brain cells
Post Your Comments:
Related Image:
Researchers ID Suite of Genes in Aging Process
(Date:11/25/2015)... ... November 25, 2015 , ... On November 10, 2015, Bohrer Brady, LLC filed ... on behalf of a home health care worker who provided companionship services for the ... care workers employed by Humana, Inc., Humana at Home, Inc., and SeniorBridge Family Companies ...
(Date:11/25/2015)... ... November 25, 2015 , ... Lakeview Health, ... country to celebrate their sobriety and show through pictures what a positive difference ... photos this Thanksgiving with the hashtag #FacesOfGratitude on their Facebook, Twitter, and Instagram ...
(Date:11/25/2015)... (PRWEB) , ... November 25, 2015 , ... ... for physicians and athletic programs, launches new Wimbledon Athletics Facebook page ... testing young athletes for unsuspected cardiac abnormalities. About 2,000 people under the age ...
(Date:11/25/2015)... ... ... Smiles by Stevens is pleased to announce the addition of Botox® for ... aware of the benefits of Botox® in the treatment of moderate facial wrinkling, few ... and pain as a result of Jaw Tension, TMJ (temporo-mandibular joint) disorder, and Bruxism ...
(Date:11/25/2015)... ... November 25, 2015 , ... Brillianteen, McGaw YMCA’s student-produced ... in its 65th Anniversary Brillianteen Revue, scheduled for March 4-6, 2016. Auditions for ... years, Brillianteen has been a treasured tradition for numerous families in the Evanston ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... , November 26, 2015 ... of the "2016 Future Horizons and ... Abuse Testing Market: Supplier Shares, Country Segment ... to their offering. --> ... "2016 Future Horizons and Growth Strategies ...
(Date:11/26/2015)... 2015 ... the  "2016 Future Horizons and Growth ... Monitoring (TDM) Market: Supplier Shares, Country ...  report to their offering.  --> ... addition of the  "2016 Future Horizons ...
(Date:11/26/2015)... , November 26, 2015 ... the addition of the  "2016 Future ... European Cell Surface Marker Testing Market: ...  report to their offering.  --> ... addition of the  "2016 Future Horizons ...
Breaking Medicine Technology: