Navigation Links
Researchers ID Inflammation-Fighting Pathway in Fat Cells
Date:6/4/2008

But this protection breaks down when obesity sets in, study finds

WEDNESDAY, June 4 (HealthDay News) -- A new molecular signaling pathway in fat cells that suppresses harmful inflammation has been identified by Harvard School of Public Health researchers. The pathway prevents the fat cells -- called adipocytes -- from over-reacting to inflammation-causing stimulants such as fatty acids in the diet.

However, the researchers also found that obesity-related cellular stress can override the protective function and turn the pathway into a trigger of chronic inflammation, leading to increased risk of insulin resistance, diabetes and other metabolic disorders.

In lean people, the newly identified signaling pathway acts as a natural counterbalance to a parallel signaling pathway that promotes inflammation and can lead to health problems.

"Overt obesity eventually overwhelms the protective effect of this pathway and flips it into the pro-inflammatory pathway," senior author Chih-Hao Lee, assistant professor of genetics and complex diseases, said in a prepared statement.

Lee and colleagues also pinpointed the molecular switch that determines which pathway is activated under different conditions. They said it may be possible to develop drugs designed to increase the protective effect to more strongly suppress inflammation and reduce the risk of insulin resistance, diabetes and other health problems.

The study was published in the journal Cell Metabolism.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about diabetes.



-- Robert Preidt



SOURCE: Harvard School of Public Health, news release, June 3, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Virginia Tech researchers find human virus in chimpanzees
2. Brown researchers work toward ending cartilage loss
3. NARSAD researchers identify specific genes and family traits linked to mental illnesses
4. Researchers identify proteins making up mechanosensitive ion channels
5. OHSU Cancer Institute researchers find novel chemo drug helps treat prostate cancer
6. UNC health researchers explore how to take interactive video games to the next level
7. OHSU Cancer Instutute researchers find abnormalities in gene for melanoma
8. Penn researchers gain new insights on spinal muscular atrophy
9. OHSU Cancer Institute researchers find many stomach cancer patients are not gertting best therapy
10. Researchers Develop Stem Line With Sickle Cell Mutation
11. New HIV browser gives researchers access to valuable data from vaccine trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/6/2016)... (PRWEB) , ... December 06, 2016 , ... ... advisory organization, is proud to announce it has added CXC Solutions (CXC) as ... management solutions. These solutions are tailored to help benefits advisors reduce operating ...
(Date:12/6/2016)... ... December 06, 2016 , ... ... portal for all the knowledge resources, including white papers, guides, handbooks, case studies, ... , To access more than 9,000 documents, webinars and videos available online, ...
(Date:12/6/2016)... ... December 06, 2016 , ... “Tatiana Sibirskaya: A Life ... story of sacrifice and enlightenment. , “Tatiana Sibirskaya: A Life Devoted ... looking for creative outlets, Carolyn gravitated toward writing through the inspiration of her ...
(Date:12/6/2016)... ... December 06, 2016 , ... U.S. Security Associates (USA) ... 125 for their industry leading training methods that engage their associates and link ... the global elite in employer-sponsored training and development programs. , “The 2017 Training ...
(Date:12/5/2016)... ... December 06, 2016 , ... For many years, Andrew G. Zubinas ... thin. The beauty of the Lithuanian language and its poetry inspired him ... book, Zubinas lyrically explores all aspects of a living, breathing forest where nothing ever ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)... 2016  CVS Health, the nation,s largest pharmacy innovation ... score of 100 percent on the Corporate Equality Index ... an annual national benchmarking survey and report on corporate ... the Human Rights Campaign Foundation. "Our ... colleagues, customers and suppliers bring to CVS Health," said ...
(Date:12/5/2016)... 2016  New research by the CVS Health ... the U.S. Department of Health and Human Services, ... Response (ASPR), published online today in JAMA ... encourage patients with chronic conditions to refill medications ... also affirms that public-private partnerships can facilitate timely ...
(Date:12/5/2016)... 5, 2016 For the third consecutive year, ... Human Rights Campaign Foundation,s (HRC) annual ... national benchmarking tool used to rate companies on policies ... employee equality. For the last 15 years, ... gauge their equality efforts, culture and business practices. The ...
Breaking Medicine Technology: