Navigation Links
Researchers ID Genes That May Determine Mental Illness
Date:4/16/2012

SUNDAY, April 15 (HealthDay News) -- Genes that increase or reduce the risk of certain mental illnesses and Alzheimer's disease have been identified by an international team of scientists.

The researchers said they also pinpointed a number of genes that may explain individual differences in brain size and intelligence.

"We searched for two things in this study," senior author Paul Thompson, a professor of neurology at the University of California, Los Angeles David Geffen School of Medicine and a member of UCLA's Laboratory of Neuro Imaging, said in a university news release.

"We hunted for genes that increase your risk for a single disease that your children can inherit. We also looked for factors that cause tissue atrophy and reduce brain size, which is a biological marker for hereditary disorders like schizophrenia, bipolar disorder, depression, Alzheimer's disease and dementia," he explained.

The researchers said this was the largest-ever brain study to date, according to the release.

The team of more than 200 scientists at 100 institutions worldwide measured the size of the brain and its memory centers in thousands of MRI images from more than 21,100 healthy people and screened the participants' DNA at the same time.

In people with smaller brains, the researchers found a consistent relationship between subtle differences in the genetic code and smaller memory centers. They also found that the same genes affected the brain in the same ways in people in different populations.

The findings may provide new potential targets for drug development.

"Millions of people carry variations in their DNA that help boost or lower their brains' susceptibility to a vast range of diseases," Thompson said. "Once we identify the gene, we can target it with a drug to reduce the risk of disease. People also can take preventive steps through exercise, diet and mental stimulation to erase the effects of a bad gene."

The researchers also found that a variant in a gene called HMGA2 may affect brain size and intelligence.

"We found fairly unequivocal proof supporting a genetic link to brain function and intelligence. For the first time, we have watertight evidence of how these genes affect the brain. This supplies us with new leads on how to mediate their impact," Thompson said.

The study was published online April 15 in the journal Nature Genetics.

Searching for clues to disorders such as autism and schizophrenia, the researchers also plan to look for genes that influence brain wiring. For that task, Thompson said they will use diffusion imaging, a new type of brain scan that tracks communication pathways among brain cells.

More information

The U.S. National Institute of Neurological Disorders and Stroke has more about the brain.

-- Robert Preidt

SOURCE: University of California, Los Angeles, news release, April 15, 2012


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
2. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
3. Researchers discover new way to kill pediatric brain tumors
4. Researchers Who Discovered First Genes for Stuttering will Present Findings to the National Stuttering Association
5. Researchers create drug to keep tumor growth switched off
6. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
7. GUMC researchers say flower power may reduce resistance to breast cancer drug tamoxifen
8. Clemson researchers develop hands-free texting application
9. Researchers find biomarkers in saliva for detection of early-stage pancreatic cancer
10. Researchers chart genomic map spanning over 2 dozen cancers
11. Researchers discover second protective role for tumor-suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers ID Genes That May Determine Mental Illness
(Date:3/22/2017)... ... March 22, 2017 , ... Wash Tower Ltd. has released a series ... Wash Tower, the world's first standalone constant pressure bidet. , The videos in the ... at https://www.washtower.com as well as on its social media pages. , Each ...
(Date:3/22/2017)... ... 2017 , ... The Rett Syndrome Research Trust (RSRT) announced ... afflicts 350,000 individuals worldwide. Rett Syndrome is caused by alterations in a ... Following a normal infancy, Rett Syndrome takes effect in toddlerhood depriving children ...
(Date:3/22/2017)... ... March 22, 2017 , ... Drs. Jennifer Houck, Lauren Smith, Heather ... accept new patients in need of skilled pediatric dentistry in Rock Hill, ... offers pediatric patients routine treatments, including cavities, sealants and fluoride applications, in a comfortable ...
(Date:3/22/2017)... ... March 22, 2017 , ... The Burke Medical ... to translate advances in basic neuroscience at the BMRI labs into new and ... to improve movement, vision, and cognition impaired by stroke, traumatic brain injury, cerebral ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... imaging core lab with extensive therapeutic experience and operational excellence in oncology clinical ... immuno-oncology clinical trial for the treatment of non-small cell lung cancer and small ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... , March 22, 2017 Under the ... pharmaceutical packaging market size increased year by year ... 2017 to 2021, the market size will maintain ... expected to outnumber RMB140 billion in 2021, thanks ... rapid development of biological agents and supporting policies. ...
(Date:3/22/2017)... -- ImaginAb Inc. today announced the appointment of Martyn Coombs ... chairman of ImaginAb, said "At ImaginAb we have exciting science and ... to our business, particularly in commercializing and making step changes in ... can realize our potential." ... Mr. Coombs is a recognized industry leader in nuclear medicine ...
(Date:3/22/2017)... 22, 2017  CANTEL MEDICAL CORP. (NYSE: CMD ... and CEO, will be presenting at the 16 th ... Central Hotel in New York . The ... 3:00 p.m. ET. In addition, management will be available for ... live audio webcast will be available via the investor relations ...
Breaking Medicine Technology: