Navigation Links
Researchers Hunt Normal Cells That Give Rise to Cancer
Date:8/11/2008

Identifying these progenitors may provide context for tumor formation, new treatments

MONDAY, Aug. 11 (HealthDay News) -- Learning more about normal cells that give rise to cancer may hold the key to understanding and treating cancer, according to Duke University Medical Center researchers who identified cells linked to a deadly brain cancer.

"Identifying the specific, normal cells that cancer come from can provide critical insight into how cancers develop. This may help us develop more rational and effective approaches to treatment," Robert Wechsler-Reya, an associate professor of pharmacology and cancer biology, said in a medical center news release.

In what's believed to be a first, the Duke team had identified two types of cells in the brain that can give rise to the malignant brain tumor medulloblastoma. It occurs most commonly in children and is treated with a combination of surgery, chemotherapy and radiation, which cause severe side effects.

In order to identify the normal cells associated with medulloblastoma, the Duke researchers and colleagues in Australia created mouse models of medulloblastoma by turning off the patched gene, an important regulator of cell growth in the cerebellum. Specifically, they switched off the patched gene in granule neuron precursors (GNPs), which make one particular type of neuron, or in stem cells, which can make all the different cell types in the cerebellum.

When the patched gene was turned off in GNPs, 100 percent of the mice developed medulloblastoma. When the gene was deleted from stem cells, most of them went on to form normal cell types within the cerebellum.

The findings provide the first definitive proof that medulloblastoma can be triggered in GNPs, the researchers said.

"Simply mutating a gene is not enough to cause cancer. The mutation has to happen in the right cell type at the right time. In the case of patched, GNPs provide the critical context for tumor formation," Wechsler-Reya said.

The study was published in the August issue of the journal Cancer Cell.

More information

The U.S. National Cancer Institute has more about cancer.



-- Robert Preidt



SOURCE: Duke University, news release, Aug. 11, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Researchers to begin study aimed at helping Latino HIV patients
2. Researchers report periodontal disease independently predicts new onset diabetes
3. Researchers Find Genes That Influence West Nile Virus
4. Researchers unveil vital key to cancer
5. Researchers find differences in swallowing mechanism of Rett syndrome patients
6. Dartmouth researchers say too many children see extreme violence in movies
7. Penn researchers find a new role for a Foxy Old Gene
8. U of M researchers find cerebral malaria may be a major cause of brain injury in African children
9. Researchers Map Americas Deadliest Roads
10. Researchers disprove long-standing belief about HIV treatment
11. Teamwork cuts out unnecessary biopsies, researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2016)... ... ... Growing in popularity, more and more people continue to live their lives ... Whether someone chooses to cut gluten out of their life for personal health reasons ... their shelves with many different gluten-free products all year round. And they take another ...
(Date:5/24/2016)... ... May 24, 2016 , ... Tuesday, May 24, Women's Excellence in Wellness, ... with Young Living Essential Oils, taught by Patti Dolan, RYT, a Young Living ... Yoga Flow is 6:30pm - 7:15pm followed by a small intro to the Oils ...
(Date:5/24/2016)... ... , ... Controlling and maintaining the home’s water heater just got infinitely easier, ... Heater Controller , a first-of-its-kind system that enables remote and convenient control of a ... does for HVAC systems, Aquanta gives users a much more efficient, versatile way to ...
(Date:5/24/2016)... (PRWEB) , ... May 24, 2016 , ... ... Milwaukee , Out patient Services To Begin In June , Aloria Health, specializing ... to announce the opening of Aloria Milwaukee, its first treatment facility for outpatient, ...
(Date:5/24/2016)... NJ (PRWEB) , ... May 24, 2016 , ... The ... that’s causing the problem. A common injury that’s often misunderstood, whiplash should be swiftly ... MD, a Harvard-trained, orthopedic spine surgeon at Atlantic Spine Center . , ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... LAWRENCE, Mass. , May 24, 2016  NxStage ... medical technology company focused on advancing renal care, today ... Officer, plans to participate in the following schedule of ... will be made available at http://ir.nxstage.com/ . ... Jefferies Healthcare Conference NY, NY           Friday, ...
(Date:5/24/2016)... , May 24, 2016 ... ™ , la première endoprothèse à ... destinés à l,intervention portant sur les membres ... OrbusNeich, entreprise mondiale spécialisée dans ... changer la vie, a élargi son portefeuille ...
(Date:5/23/2016)... PUNE, India , May 23, 2016 ... is spread across 163 pages, profiles 12 companies and ... 280 tables and figures on the industry and its ... study that is comprehensive in nature, details the current ... of the industry including definitions, classifications, applications and industry ...
Breaking Medicine Technology: