Researchers Hone in on Cancer Stem Cells fo... ( For the first time researchers say ta...)

Researchers Hone in on Cancer Stem Cells for Melanoma

Date:1/16/2008

For the first time, researchers say targeting these units can slow down tumor growth

WEDNESDAY, Jan. 16 (HealthDay News) -- Melanoma has joined the list of cancers that can arise from a rare population of primordial cancer stem cells, Harvard researchers report.

Even more importantly, the scientists demonstrated for the first time that targeting these cells can slow down the growth of a tumor.

"The findings validate for the first time the potential therapeutic utility of the cancer stem cell concept," explained study author Markus Frank. "To my knowledge, cancer stem cells have not been specifically targeted to date via a prospective molecular marker."

Frank and his colleagues were interested in a particular protein called ABCB5, which is expressed on the surface of some progenitor skin cells and has been shown to confer cancer drug resistance to melanoma.

Hypothesizing that the pool of ABCB5-positive cells could include cancer stem cells, the researchers separated human melanoma cells based on whether or not they expressed ABCB5, transplanted both types of cells into mice, and monitored their ability to form tumors.

Fourteen of 23 mice injected with ABCB5-positive cells developed tumors, compared to one of 23 mice injected with cells that did not express the protein.

When a mixture of both types of cells were injected into mice, the authors found the ABCB5-positive cells were more likely to fuel tumors, and they exhibited stem cell-like properties -- that is, they divided to form both the bulk of the tumor and to regenerate the stem cells themselves.

Those findings -- that a stem cell subpopulation appears to contain the ability to reconstitute a tumor -- have been observed before in colon, brain, breast and pancreatic cancers, among others, albeit using a different cellular protein. However, the Harvard researchers added a novel twist: They showed both that ABCB5 expressi
'/>"/>

0

GOOD

Page: 1 2 3
Related medicine news :

1. Anyone can save a life: Penn researchers lead national efforts to improve CPR quality
2. Researchers find new way to block destructive rush of immune cells
3. U of M researchers create beating heart in laboratory
4. Researchers challenge previous findings regarding widely used asthma treatment
5. UT Health Science Center researchers decoding saliva to detect breast cancer
6. Protein power: Researchers trigger insulin production in diabetic mice
7. Researchers use neuroimaging to study ESP
8. UGA researchers receive $9 million in grants to study barriers to effective addiction treatment
9. Researchers seek to make cavity-causing bacteria self-destruct
10. Human factors researchers test voting systems for seniors that can improve voting accuracy and speed
11. New research tools are too complex for easy answers, researchers say

Post Your Comments:

Related Image:

Researchers Hone in on Cancer Stem Cells for Melanoma

(Date:5/19/2013)... 2013 These molecular diagnostics market ... Spain, Japan, Italy, Germany and France:, ... laboratory practice, as well as key economic, regulatory, ... impact during the next five years. , ... technologies, test formats, detection methodologies, trends in testing ...

(Date:5/19/2013)... May 19, 2013 Americans live closer ... the newest American Veterinary Medical Association (AVMA) U.S. Pet ... dog owners consider their dog a member of the ... said as much five years earlier. , According to ... of the national income dedicated to pets has increased ...

(Date:5/19/2013)... Vegas Hotel Escapes, the premier Las ... launch it's all new vacation packages for the upcoming ... Consumers traveling to Las Vegas will be pleased to ... website. Travelers will be pleased to know that VegasHotelEscapes.com ... Vegas Hotel Escapes specializes in helping consumers Las ...

(Date:5/19/2013)... Passages Malibu, the leading non-12 step, holistic, and ... the launch of a “Sobriety, Health, and Wellness” survey ... “We are always looking for new ways to engage ... regarding sobriety, what’s working for people, and what isn’t,” ... Passages Addiction Treatment Centers located in Malibu and ...

(Date:5/19/2013)... HealthEconomics.Com , the global leader ... unveil a new and exciting service: HE-Xpo: a media-rich, ... array of real-time communication tools to expand their digital ... , HE-Xpo is powered by OnStream Media’s ... feel of being at a physical trade show, all ...

Breaking Medicine News(10 mins):Health News:Molecular Diagnostics Market - US, UK, Spain, Japan, Italy, Germany & France Analysis in New Research Report at ReportsnReports.com 2 Health News:Molecular Diagnostics Market - US, UK, Spain, Japan, Italy, Germany & France Analysis in New Research Report at ReportsnReports.com 3 Health News:Molecular Diagnostics Market - US, UK, Spain, Japan, Italy, Germany & France Analysis in New Research Report at ReportsnReports.com 4 Health News:Dogs Becoming Part of the Family: Dog Bite Injuries Decreasing 2 Health News:Dogs Becoming Part of the Family: Dog Bite Injuries Decreasing 3 Health News:Passages Malibu Announces its Sobriety, Health, and Wellness Social Media Survey 2 Health News:Passages Malibu Announces its Sobriety, Health, and Wellness Social Media Survey 3 Health News:HealthEconomics.Com Announces HE-Xpo, a New Virtual Trade Show Devoted to Healthcare Value and Market Access 2 Health News:HealthEconomics.Com Announces HE-Xpo, a New Virtual Trade Show Devoted to Healthcare Value and Market Access 3

[0] Molecular Diagnostics Market - US, UK, Spain, Japan, Italy, Germany & France Analysis in New Research Report at ReportsnReports.com [0] Dogs Becoming Part of the Family: Dog Bite Injuries Decreasing [0] VegasHotelEscapes.com Announces Special Vegas Packages For Billboard Music Awards [0] Passages Malibu Announces its Sobriety, Health, and Wellness Social Media Survey [0] HealthEconomics.Com Announces HE-Xpo, a New Virtual Trade Show Devoted to Healthcare Value and Market Access

... Programs During the Quarter, PALO ALTO, Calif., Nov. ... announced financial results for,the quarter ended September 30, 2007. ... of 2007 was $19.4,million, compared to net income of ... in the quarter ended September 30, 2006 included $31.6,million ...

... NEW YORK, Nov. 6 Weight Watchers,International, Inc. (NYSE: ... 29, 2007. Third Quarter 2007 Results For the ... to $337.5 million, up from $284.8 million in the third ... in the third quarter,of 2007 to $0.62 versus $0.52 in ...

... looks at hospital discharge rates in Raleigh and 6 ... ... County EMS has,participated in a seven-city study on the impact of new ... Heart,Association,s new 2005 CPR guidelines, according to the study authors in a,presentation ...

... rates in Cypress Creek and ... 6 other cities, ... in a seven-city study on the impact of new CPR techniques,the results ... CPR guidelines, according to the study authors in a,presentation at the AHA,s ...

... with Cardiac Resynchronization Therapy, researchers say , TUESDAY, Nov. ... a device that synchronizes pumping in the heart,s ventricles ... The results were presented Tuesday at a late-breaking clinical ... in Orlando, Fla., and were expected to be published ...

... Institute of Allergy and Infectious Diseases (NIAID), part of ... to strengthen and expand its nationwide group of institutions ... for infectious diseases. In addition to increasing the number ... Vaccine and Treatment Evaluation Units (VTEUs) to carry out ...

Jazz Pharmaceuticals, Inc. Announces Third Quarter 2007 Financial Results Weight Watchers Announces Third Quarter 2007 Results Raleigh in National Study, Shows Survival to Hospital Discharge After Cardiac Arrest Doubles With Improved CPR and Impedance Threshold Device Cypress Creek in National Study, Shows Survival To Hospital Discharge After Cardiac Arrest Doubles with Improved CPR and Impedance Threshold Device Cardiac Device Won't Help Some Heart Failure Patients NIAID strengthens and expands Vaccine and Treatment Evaluation Units

(Date:5/17/2013)... CHAPEL HILL, N.C. , May 17, 2013 ... on how organizations communicate internally. Faced with a ... adjust their strategies and tactics for communicating with ... the effectiveness of all the strategies, tactics and ... In a new study, Best ...

(Date:5/17/2013)... 17, 2013 Sony Biotechnology Inc. ("Sony") today announced ... (SP6800). Sony will be exhibiting and taking orders for ... at the San Diego Convention ... from May 20 - 22. The ... commercial audio-visual technologies into new and novel functionalities for ...

(Date:5/17/2013)... TechAtlas Group has announced the release of ... for the Chronic Kidney Disease (CKD) market. This ... drugs and devices currently on the market and ... (Logo: http://photos.prnewswire.com/prnh/20130517/NE16011LOGO ) ... renal denervation , diabetic nephropathy - antifibrotics ...

Breaking Medicine Technology:Internal Communication Strategies and Tactics that Resonate with Key Stakeholders and Drive Organizational Effectiveness 2 Sony Biotechnology Inc.'s New Technology for Science Provides Researchers Results in Color 2 TechAtlas Group Releases Innovative Chronic Kidney Disease Landscape Map 2

[0] Internal Communication Strategies and Tactics that Resonate with Key Stakeholders and Drive Organizational Effectiveness [0] Sony Biotechnology Inc.'s New Technology for Science Provides Researchers Results in Color [0] TechAtlas Group Releases Innovative Chronic Kidney Disease Landscape Map

... PARK, Calif., Sept. 14 Praxis EMR has submitted its ... EMRs to apply for HITECH certification in the country. Under ... in federal incentives if they can demonstrate "meaningful use" of ... the U.S. Department of Health and Human Services to test ...

... Reportlinker.com announces that a new market research ... Autistic Disorder - Pipeline Assessment and Market ... Autistic Disorder - Pipeline ... SummaryGlobalData, the industry analysis specialist, has released ...

Cached Medicine Technology:Praxis EMR Among First to Apply for HITECH Certification 2 Reportlinker Adds Autistic Disorder - Pipeline Assessment and Market Forecasts to 2017 2 Reportlinker Adds Autistic Disorder - Pipeline Assessment and Market Forecasts to 2017 3

Praxis EMR Among First to Apply for HITECH Certification Reportlinker Adds Autistic Disorder - Pipeline Assessment and Market Forecasts to 2017

... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...

... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...

... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...

... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...

Medicine Products:

Xylocaine White Blood Cell Count Western Equine Encephalitis Antibody, IgM by IFA, Serum West Nile Virus RNA by RT-PCR