Navigation Links
Researchers Gain Insights Into 'On-Off' Switch for Cells
Date:3/24/2008

Finding could one day lead to new treatments for diseases such as cancer

MONDAY, March 24 (HealthDay News) -- New insights about an on-off switch that controls cell growth could one day help identify targets for drugs to treat cancer and other diseases that involve unnatural cell growth, researchers are reporting.

The researchers at the Duke Institute for Genome Sciences and Policy found that if the switch is "on," then a cell will divide, even if it's damaged or the signal to grow disappears.

The on-off switch is part of the pathway that controls cell division, the process that creates new cells. Before a cell divides, it goes through a checklist to make sure everything is in order. If the cell senses a problem early on, it can halt the process. But once the cell passes what's called the restriction point, it can no longer stop division. This on-off switch controls the restriction point and therefore plays an important role in cell growth, according to the study.

The on-off switch is part of the Rb-E2F signaling pathway. Rb (retinoblastoma) is an important tumor suppressor gene, and E2F is a transcription factor that governs the expression of all the genes important for cell growth, the researchers explained.

This pathway is found in all multi-cellular life forms, from humans to plants. The pathway is triggered when a cell receives an external chemical signal to grow.

"The wiring diagram is fundamentally the same. It's very likely that different organisms have evolved a very conserved design principle to regulate their growth," study lead author Guang Yao, a postdoctoral fellow in Duke's department of molecular genetics and microbiology, said in a prepared statement.

In their study, Yao and colleagues also found that the switch is bistable -- once it's turned on by an external signal, it can stay turned on, even if the signal vanishes.

The study results are published in the April issue of the journal Nature Cell Biology.

More information

The Biology Project at the University of Arizona has more about cells.



-- Robert Preidt



SOURCE: Duke University, news release, March 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Molecular science could further improve leukemia survival, say St. Jude researchers
2. Stanford researchers unmask proteins in telomerase, a substance that enables cancer
3. Recognizing outstanding young researchers
4. Researchers sharpen search for new marine medicines with novel techniques
5. Global Sound Conference Brings Worlds Top Sound Researchers, Technologists and Musicians to Los Angeles for Four Day Symposium
6. Queensland researchers get the latest tools to fight cancer
7. Researchers find 1 in 6 women, 1 in 10 men at risk for Alzheimers disease in their lifetime
8. Researchers discover second depth-perception method in brain
9. Researchers study new drug and indications for heated chemotherapy treatment
10. Researchers use light to detect Alzheimers
11. Penn researchers identify first sex chromosome gene involved in meiosis and male infertility
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Gain Insights Into 'On-Off' Switch for Cells
(Date:10/13/2017)... ... October 13, 2017 , ... ProVest Insurance Group, ... Dallas, Miami, and Raleigh regions, is organizing an extended charity drive to benefit ... deadly chromosome abnormality. , After struggling since birth with several health challenges, T.J. ...
(Date:10/13/2017)... Pa. (PRWEB) , ... October 13, 2017 , ... While ... dark poses a problem. Fortunately, an inventor from Austin, Texas, has identified a solution. ... to medication in darkness or restricted lighting. As such, it eliminates the need to ...
(Date:10/13/2017)... ... , ... PurhealthRX , a leading Health and Nutrition Company, is announcing ... full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing the ... incorporated into liquid products, while reducing costs to end users. , The team of ...
(Date:10/13/2017)... ... 2017 , ... Apple Rehab Shelton Lakes , which specializes in the ... facility as part of a disaster drill on October 3rd. , Apple Rehab participated ... Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid Plan ...
(Date:10/13/2017)... ... 2017 , ... Ellevate Network, the leading network for professional women, brought together ... equality at their inaugural Summit in New York City in June. The event was ... of over 3 million. To watch the Mobilize Women video, click here . ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... -- Caris Life Sciences ® , a leading innovator in ... medicine, today announced that St. Jude Medical Center,s Crosson ... as its 17 th member. Through participation with ... Institute will help develop standards of care and best ... cancer treatment more precise and effective. ...
(Date:10/11/2017)... , Oct. 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") ... Surgical facility in Las Piedras, Puerto Rico ... and blades. ... the facility sustained minor structural damage, temporary loss of ... Repairs have been completed, manufacturing operations have resumed, and ...
(Date:10/10/2017)... Oct. 10, 2017   West Pharmaceutical Services, Inc. ... for injectable drug administration, today shared the results of ... for improving the intradermal administration of polio vaccines. The ... Summit in May 2017 by Dr. Ondrej Mach ... World Health Organization (WHO), and recently published in the ...
Breaking Medicine Technology: