Navigation Links
Researchers Gain Insights Into 'On-Off' Switch for Cells
Date:3/24/2008

Finding could one day lead to new treatments for diseases such as cancer

MONDAY, March 24 (HealthDay News) -- New insights about an on-off switch that controls cell growth could one day help identify targets for drugs to treat cancer and other diseases that involve unnatural cell growth, researchers are reporting.

The researchers at the Duke Institute for Genome Sciences and Policy found that if the switch is "on," then a cell will divide, even if it's damaged or the signal to grow disappears.

The on-off switch is part of the pathway that controls cell division, the process that creates new cells. Before a cell divides, it goes through a checklist to make sure everything is in order. If the cell senses a problem early on, it can halt the process. But once the cell passes what's called the restriction point, it can no longer stop division. This on-off switch controls the restriction point and therefore plays an important role in cell growth, according to the study.

The on-off switch is part of the Rb-E2F signaling pathway. Rb (retinoblastoma) is an important tumor suppressor gene, and E2F is a transcription factor that governs the expression of all the genes important for cell growth, the researchers explained.

This pathway is found in all multi-cellular life forms, from humans to plants. The pathway is triggered when a cell receives an external chemical signal to grow.

"The wiring diagram is fundamentally the same. It's very likely that different organisms have evolved a very conserved design principle to regulate their growth," study lead author Guang Yao, a postdoctoral fellow in Duke's department of molecular genetics and microbiology, said in a prepared statement.

In their study, Yao and colleagues also found that the switch is bistable -- once it's turned on by an external signal, it can stay turned on, even if the signal vanishes.

The study results are published in the April issue of the journal Nature Cell Biology.

More information

The Biology Project at the University of Arizona has more about cells.



-- Robert Preidt



SOURCE: Duke University, news release, March 23, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Molecular science could further improve leukemia survival, say St. Jude researchers
2. Stanford researchers unmask proteins in telomerase, a substance that enables cancer
3. Recognizing outstanding young researchers
4. Researchers sharpen search for new marine medicines with novel techniques
5. Global Sound Conference Brings Worlds Top Sound Researchers, Technologists and Musicians to Los Angeles for Four Day Symposium
6. Queensland researchers get the latest tools to fight cancer
7. Researchers find 1 in 6 women, 1 in 10 men at risk for Alzheimers disease in their lifetime
8. Researchers discover second depth-perception method in brain
9. Researchers study new drug and indications for heated chemotherapy treatment
10. Researchers use light to detect Alzheimers
11. Penn researchers identify first sex chromosome gene involved in meiosis and male infertility
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Gain Insights Into 'On-Off' Switch for Cells
(Date:10/13/2017)... ... October 13, 2017 , ... ... process to promote standards of excellence for the field of eating disorders, announces ... 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... Calif. (PRWEB) , ... October 13, 2017 , ... Many ... dementia. However, many long-term care insurance companies have a waiver for care if the ... 90-day elimination period, when the family pays for care, is often waived, so the ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
(Date:10/12/2017)... San Francisco, CA (PRWEB) , ... October 12, ... ... and Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus ... sleep apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral ...
(Date:10/12/2017)... ... ... Asante, a nationally recognized health system in southern Oregon, ... health joint venture through an agreement, effective October 1, 2017, to create AccentCare ... company with Asante, delivering clinically integrated care, for the past eight years. This ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/2/2017)... 2017 Diplomat Pharmacy, Inc. (NYSE: ... Consulting, LLC , and named its founder as Diplomat,s ... Tennessee , will operate under Diplomat ... service offerings for health care partners to include IT ... "In an interoperable world, technology delivers comprehensive ...
(Date:9/28/2017)... Sept. 28, 2017 Hill-Rom Holdings, Inc. (NYSE: ... conference call and webcast on Friday, November 3, 2017, ... and ending at approximately 8:30 a.m. (CDT) / 9:30 ... company,s 2017 financial performance and guidance for 2018, Hill-Rom ... to enhance operational performance, and long-range financial outlook through ...
Breaking Medicine Technology: