Navigation Links
Researchers Gain Insights Into Aging in Mice
Date:1/8/2009

Finding might one day lead to extended life spans

THURSDAY, Jan. 8 (HealthDay News) -- Stanford University researchers have linked two previously thought-to-be-separate pathways tied to aging, at least in mice, leading to more thought that physically getting older is an orderly and deliberate genetic occurrence.

Short-circuiting that process might one day allow scientists to extend life and delay aging, the researchers said.

"There is a genetic process that has to be on, and enforced, in order for aging to happen," Dr. Howard Chang, associate professor of dermatology at the university's medical school, said in a news release issued by Stanford. "It's possible that those rare individuals who live beyond 100 years have a less-efficient version of this master pathway, just as children with progeria -- a genetic aging disease -- may have components of this pathway that are more active."

The findings, published in the Jan. 9 issue of Cell, link pathways involving the SIRT6 and NF-kappa B, or NF-kB, protein molecules. SIRT6, part of the sirtuin family of proteins, regulates life span in some simple organisms, and NF-kB regulates production of certain genes involved in aging. It has previously been found that blocking NF-kB activity in skin cells of elderly mice makes the cells look and act like younger cells.

The research team found that SIRT6 links up to an NF-kB subunit, possibly causing changes in humans and mice that make it harder for NF-kB to do its job.

"It seems that an important job of SIRT6 is to restrain NF-kB and limit the expression of genes associated with aging," Chang said.

But in genetically altered mice without the SIRT6 protein, the number of NF-kB-dependent genes involved in immune response, cell signaling and metabolism grows to a level that previous studies had shown could cause a fatal aging-like condition for mice less than 4 weeks old, the researchers said.

"Mice lacking SIRT6 seem to hit some kind of a wall at around 4 weeks of age when their blood sugar drops to a level barely compatible with life," Dr. Katrin Chua, assistant professor of endocrinology, gerontology and metabolism at Stanford, said in the news release. "Reducing NF-kB activity somehow allows the mice to get over this critical period and to live much longer."

Trying to figure out how NF-kB knows the timing and extent of its role in aging and how SIRT6 might affect this is the next step for the researchers.

"It's a very provocative question," Chang said. "We've tied together two previously separate pathways in aging. Now we'd like to better understand what regulates that pathway."

More information

The U.S. Centers for Disease Control and Prevention has more about healthy aging.



-- Kevin McKeever



SOURCE: Stanford University, news release, Jan. 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Researchers discover target that could ease spinal muscular atrophy symptoms
2. Health-monitoring technology helps seniors live at home longer, MU researchers find
3. Old gastrointestinal drug slows aging, McGill researchers say
4. NC State researchers find new bartonella species that infects humans
5. Researchers Report Progress in Fight Against Fat
6. Mayo researchers offer new insight into effectiveness of procedure to stop heavy menstrual bleeding
7. Burnham researchers illuminate mechanisms that regulate DNA damage control and replication
8. Relocation plan of metastatic cancer cells uncovered by Stanford researchers
9. Researchers at Columbia University Medical Center link blood sugar to normal cognitive aging
10. Researchers create smaller, brighter probe tailored for molecular imaging and tumor targeting
11. Nutritious fast-food kids meals are scarce, researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... ... Curemark, LLC announced today that the Blüm Study, a Phase 3 clinical ... Autism, is now enrolling at three new sites. These new sites are in addition ... “There are currently no approved drugs that address the core symptoms of autism,” said ...
(Date:2/23/2017)... ... February 23, 2017 , ... Carlos Gutierrez has lived his ... to spiritually evolve, which is the purpose of everyone in this universe. As Gutierrez ... (published by Balboa Press) attempts to guide readers to expand one’s spiritual life. , ...
(Date:2/22/2017)... ... February 22, 2017 , ... Gevir, a New Zealand-based company that ... its products are coming soon to Amazon.com, the world’s largest online retailer. ... means to develop an effective natural treatment for Shelley’s Multiple Sclerosis, which she’d been ...
(Date:2/22/2017)... MD (PRWEB) , ... February 22, 2017 , ... ... Direct secure messaging services to the largest network of hospitals, health information ... the National Coordinator for Health Information Technology (ONC-HIT) 2015 Edition Health IT Module ...
(Date:2/22/2017)... CRANBURY, N.J. (PRWEB) , ... February 22, 2017 ... ... than a one-size-fits-all approach, leads to fewer trips the emergency room, fewer hospital ... in The American Journal of Managed Care® (AJMC®) finds. The study can be ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... Summary Provides understanding and ... entered into by the worlds leading healthcare companies. ... Description The Global Atherosclerosis Partnering Terms and ... to partnering deals and agreements entered into by ... Trends in partnering deals - Top deals ...
(Date:2/22/2017)... Feb. 22, 2017 Summary Provides ... deals and agreements entered into by the worlds leading ... Description The Global Motor Neurone Disease Partnering ... access to partnering deals and agreements entered into by ... in partnering deals - Top deals by value ...
(Date:2/22/2017)... , February 22, 2017 ... microscopy market are Olympus Corporation, Nikon Corporation, and ... or 75% in the overall market in 2015. ... product innovation through result-oriented research and development activities ... expected to focus on expanding their business to ...
Breaking Medicine Technology: