Navigation Links
Researchers Gain Insights Into Aging in Mice
Date:1/8/2009

Finding might one day lead to extended life spans

THURSDAY, Jan. 8 (HealthDay News) -- Stanford University researchers have linked two previously thought-to-be-separate pathways tied to aging, at least in mice, leading to more thought that physically getting older is an orderly and deliberate genetic occurrence.

Short-circuiting that process might one day allow scientists to extend life and delay aging, the researchers said.

"There is a genetic process that has to be on, and enforced, in order for aging to happen," Dr. Howard Chang, associate professor of dermatology at the university's medical school, said in a news release issued by Stanford. "It's possible that those rare individuals who live beyond 100 years have a less-efficient version of this master pathway, just as children with progeria -- a genetic aging disease -- may have components of this pathway that are more active."

The findings, published in the Jan. 9 issue of Cell, link pathways involving the SIRT6 and NF-kappa B, or NF-kB, protein molecules. SIRT6, part of the sirtuin family of proteins, regulates life span in some simple organisms, and NF-kB regulates production of certain genes involved in aging. It has previously been found that blocking NF-kB activity in skin cells of elderly mice makes the cells look and act like younger cells.

The research team found that SIRT6 links up to an NF-kB subunit, possibly causing changes in humans and mice that make it harder for NF-kB to do its job.

"It seems that an important job of SIRT6 is to restrain NF-kB and limit the expression of genes associated with aging," Chang said.

But in genetically altered mice without the SIRT6 protein, the number of NF-kB-dependent genes involved in immune response, cell signaling and metabolism grows to a level that previous studies had shown could cause a fatal aging-like condition for mice less than 4 weeks old, the researchers said.

"Mice lacking SIRT6 seem to hit some kind of a wall at around 4 weeks of age when their blood sugar drops to a level barely compatible with life," Dr. Katrin Chua, assistant professor of endocrinology, gerontology and metabolism at Stanford, said in the news release. "Reducing NF-kB activity somehow allows the mice to get over this critical period and to live much longer."

Trying to figure out how NF-kB knows the timing and extent of its role in aging and how SIRT6 might affect this is the next step for the researchers.

"It's a very provocative question," Chang said. "We've tied together two previously separate pathways in aging. Now we'd like to better understand what regulates that pathway."

More information

The U.S. Centers for Disease Control and Prevention has more about healthy aging.



-- Kevin McKeever



SOURCE: Stanford University, news release, Jan. 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Researchers discover target that could ease spinal muscular atrophy symptoms
2. Health-monitoring technology helps seniors live at home longer, MU researchers find
3. Old gastrointestinal drug slows aging, McGill researchers say
4. NC State researchers find new bartonella species that infects humans
5. Researchers Report Progress in Fight Against Fat
6. Mayo researchers offer new insight into effectiveness of procedure to stop heavy menstrual bleeding
7. Burnham researchers illuminate mechanisms that regulate DNA damage control and replication
8. Relocation plan of metastatic cancer cells uncovered by Stanford researchers
9. Researchers at Columbia University Medical Center link blood sugar to normal cognitive aging
10. Researchers create smaller, brighter probe tailored for molecular imaging and tumor targeting
11. Nutritious fast-food kids meals are scarce, researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... 2016 , ... "FCPX editors can now reveal their media with growing colorful ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Color brings the ... can now reveal the media of their split screens with growing colorful panels. , ...
(Date:6/26/2016)... ... ... Quality metrics are proliferating in cancer care, and are derived from many ... the beholder, according to experts who offered insights and commentary in the current issue ... the full issue, click here . , For the American Society of Clinical ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are confused ... endometriosis. These women need a treatment plan to not only alleviate symptoms and ... help for preservation of fertility and ultimately achieving a pregnancy. The specialists at ...
(Date:6/25/2016)... ... 25, 2016 , ... First Choice Emergency Room , the largest network ... the Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased ... location,” said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... , June 23, 2016 , ... on Thursday, July 7, 2016 , , , , LOCATION: ... , , , , EXPERT PANELISTS:  , , , ... Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and ... The global pharmaceutical industry is witnessing an exceptional era. ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... environments  Oticon , industry leaders in ... the launch of Oticon Opn ™, the world,s ... world of possibilities for IoT devices.      ... Opn, Oticon introduces a number of ,world firsts,: ...
Breaking Medicine Technology: