Navigation Links
Researchers Gain Insights Into Aging in Mice
Date:1/8/2009

Finding might one day lead to extended life spans

THURSDAY, Jan. 8 (HealthDay News) -- Stanford University researchers have linked two previously thought-to-be-separate pathways tied to aging, at least in mice, leading to more thought that physically getting older is an orderly and deliberate genetic occurrence.

Short-circuiting that process might one day allow scientists to extend life and delay aging, the researchers said.

"There is a genetic process that has to be on, and enforced, in order for aging to happen," Dr. Howard Chang, associate professor of dermatology at the university's medical school, said in a news release issued by Stanford. "It's possible that those rare individuals who live beyond 100 years have a less-efficient version of this master pathway, just as children with progeria -- a genetic aging disease -- may have components of this pathway that are more active."

The findings, published in the Jan. 9 issue of Cell, link pathways involving the SIRT6 and NF-kappa B, or NF-kB, protein molecules. SIRT6, part of the sirtuin family of proteins, regulates life span in some simple organisms, and NF-kB regulates production of certain genes involved in aging. It has previously been found that blocking NF-kB activity in skin cells of elderly mice makes the cells look and act like younger cells.

The research team found that SIRT6 links up to an NF-kB subunit, possibly causing changes in humans and mice that make it harder for NF-kB to do its job.

"It seems that an important job of SIRT6 is to restrain NF-kB and limit the expression of genes associated with aging," Chang said.

But in genetically altered mice without the SIRT6 protein, the number of NF-kB-dependent genes involved in immune response, cell signaling and metabolism grows to a level that previous studies had shown could cause a fatal aging-like condition for mice less than 4 weeks old, the researchers said.

"Mice lacking SIRT6 seem to hit some kind of a wall at around 4 weeks of age when their blood sugar drops to a level barely compatible with life," Dr. Katrin Chua, assistant professor of endocrinology, gerontology and metabolism at Stanford, said in the news release. "Reducing NF-kB activity somehow allows the mice to get over this critical period and to live much longer."

Trying to figure out how NF-kB knows the timing and extent of its role in aging and how SIRT6 might affect this is the next step for the researchers.

"It's a very provocative question," Chang said. "We've tied together two previously separate pathways in aging. Now we'd like to better understand what regulates that pathway."

More information

The U.S. Centers for Disease Control and Prevention has more about healthy aging.



-- Kevin McKeever



SOURCE: Stanford University, news release, Jan. 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Researchers discover target that could ease spinal muscular atrophy symptoms
2. Health-monitoring technology helps seniors live at home longer, MU researchers find
3. Old gastrointestinal drug slows aging, McGill researchers say
4. NC State researchers find new bartonella species that infects humans
5. Researchers Report Progress in Fight Against Fat
6. Mayo researchers offer new insight into effectiveness of procedure to stop heavy menstrual bleeding
7. Burnham researchers illuminate mechanisms that regulate DNA damage control and replication
8. Relocation plan of metastatic cancer cells uncovered by Stanford researchers
9. Researchers at Columbia University Medical Center link blood sugar to normal cognitive aging
10. Researchers create smaller, brighter probe tailored for molecular imaging and tumor targeting
11. Nutritious fast-food kids meals are scarce, researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2017)... ... 2017 , ... Today, June 27th is PTSD Awareness Day. Over half a ... receive adequate care due to lack of effective treatments, fear of stigma or insufficient ... left untreated, veterans are at an increased risk for self-destructive behavior, including alcohol/drug abuse, ...
(Date:6/27/2017)... (PRWEB) , ... June 27, 2017 , ... East Los ... bites can indicate about early life experiences. What happens to a woman during pregnancy ... stresses after birth can also take a toll on a baby’s long-term health. This ...
(Date:6/26/2017)... ... June 26, 2017 , ... Torrance dentist, Dr. Robert Mondavi DDS , ... most noticeable aspects of a person’s appearance. A healthy, radiant smile can make a ... balanced teeth, everyone can have the smile of their dreams with cosmetic dentistry. , ...
(Date:6/26/2017)... ... June 26, 2017 , ... ... & Sexual Medicine Specialists, in collaboration with the Fertility Center of California, is ... care: PESA (percutaneous epidydimal sperm aspiration) and TESA (percutaneous testicular sperm extraction). These ...
(Date:6/26/2017)... ... June 26, 2017 , ... ... a recent review of government data released by the United Soybean Board. ... practices, Maryland’s soybean farmers have increased their productivity on less land per bushel, ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... , June 16, 2017  Exactly 50 years ago ... off what later became known as the San Francisco "Summer ... ) is unveiling two radical innovations in strategic market research ... This announcement marks the beginning of Northern Light,s "Summer of ... ...
(Date:6/14/2017)... -- The Bio Supply Management Alliance (BSMA) has announced ... and the Biomedical Manufacturing Network to advance the ... California by providing a platform for imparting ... development. The primary focus of this alliance is to ... as small and mid-sized biomedical companies. ...
(Date:6/13/2017)... June 13, 2017 Zimmer Biomet Holdings, Inc. (NYSE ... announced that the U.S. Food and Drug Administration (FDA) has ... 2015 relating to its Zhejiang, China ... "The successful clearance of the Warning Letter related ... facility is a measure of the progress we have made ...
Breaking Medicine Technology: