Navigation Links
Researchers Gain Insights Into Aging in Mice
Date:1/8/2009

Finding might one day lead to extended life spans

THURSDAY, Jan. 8 (HealthDay News) -- Stanford University researchers have linked two previously thought-to-be-separate pathways tied to aging, at least in mice, leading to more thought that physically getting older is an orderly and deliberate genetic occurrence.

Short-circuiting that process might one day allow scientists to extend life and delay aging, the researchers said.

"There is a genetic process that has to be on, and enforced, in order for aging to happen," Dr. Howard Chang, associate professor of dermatology at the university's medical school, said in a news release issued by Stanford. "It's possible that those rare individuals who live beyond 100 years have a less-efficient version of this master pathway, just as children with progeria -- a genetic aging disease -- may have components of this pathway that are more active."

The findings, published in the Jan. 9 issue of Cell, link pathways involving the SIRT6 and NF-kappa B, or NF-kB, protein molecules. SIRT6, part of the sirtuin family of proteins, regulates life span in some simple organisms, and NF-kB regulates production of certain genes involved in aging. It has previously been found that blocking NF-kB activity in skin cells of elderly mice makes the cells look and act like younger cells.

The research team found that SIRT6 links up to an NF-kB subunit, possibly causing changes in humans and mice that make it harder for NF-kB to do its job.

"It seems that an important job of SIRT6 is to restrain NF-kB and limit the expression of genes associated with aging," Chang said.

But in genetically altered mice without the SIRT6 protein, the number of NF-kB-dependent genes involved in immune response, cell signaling and metabolism grows to a level that previous studies had shown could cause a fatal aging-like condition for mice less than 4 weeks old, the researchers said.

"Mice lacking SIRT6 seem to hit some kind of a wall at around 4 weeks of age when their blood sugar drops to a level barely compatible with life," Dr. Katrin Chua, assistant professor of endocrinology, gerontology and metabolism at Stanford, said in the news release. "Reducing NF-kB activity somehow allows the mice to get over this critical period and to live much longer."

Trying to figure out how NF-kB knows the timing and extent of its role in aging and how SIRT6 might affect this is the next step for the researchers.

"It's a very provocative question," Chang said. "We've tied together two previously separate pathways in aging. Now we'd like to better understand what regulates that pathway."

More information

The U.S. Centers for Disease Control and Prevention has more about healthy aging.



-- Kevin McKeever



SOURCE: Stanford University, news release, Jan. 8, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Researchers discover target that could ease spinal muscular atrophy symptoms
2. Health-monitoring technology helps seniors live at home longer, MU researchers find
3. Old gastrointestinal drug slows aging, McGill researchers say
4. NC State researchers find new bartonella species that infects humans
5. Researchers Report Progress in Fight Against Fat
6. Mayo researchers offer new insight into effectiveness of procedure to stop heavy menstrual bleeding
7. Burnham researchers illuminate mechanisms that regulate DNA damage control and replication
8. Relocation plan of metastatic cancer cells uncovered by Stanford researchers
9. Researchers at Columbia University Medical Center link blood sugar to normal cognitive aging
10. Researchers create smaller, brighter probe tailored for molecular imaging and tumor targeting
11. Nutritious fast-food kids meals are scarce, researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical associate professor ... prevention of cardiovascular diseases during the 15th Annual Women’s Health Conference. The ...
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for ... for action towards gender equality at their inaugural Summit in New York City in ... reached a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... “The Journey: ... faced every danger possible to save lost souls in the Philippines. “The Journey: From ... Carole is a dedicated teacher of the Bible. She has taught all ages and ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s to ... and tested to meet the highest standard. , These products are also: ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... Restoration, has recently contributed a medical article to the newly revamped Cosmetic ... Mohebi’s article spotlights the hair transplant procedure known as Follicular Unit Extraction ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... --  Divoti USA will engrave and process all ... the latest FDA requirements, which stipulates new criteria regarding medical device ... of Medical ID jewelry such as Medical ID Bracelets, can rest ... terms of the new FDA requirements . ... Divoti offers this dark mark fiber laser engraving ...
(Date:10/11/2017)... Oct. 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: ... facility in Las Piedras, Puerto Rico ... blades. Following ... facility sustained minor structural damage, temporary loss of power ... have been completed, manufacturing operations have resumed, and the ...
(Date:10/4/2017)... 2017  South Korean-based healthcare product Development Company I.M. ... on Kickstarter. The device will educate the user about ... better efficiency compared to the dated and pricey CPR ... efficacy of the compression for a more informed CPR ... to raise $5,000. ...
Breaking Medicine Technology: