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Researchers Find More Genes Linked to Lung Cancer
Date:10/22/2008

e DNA sequence of these genes with the same genes in normal tissue from the same patients.

"By doing this, we identified 26 genes that are frequently mutated in lung adenocarcinoma," Meyerson said. "Most of these gene mutations are newly discovered."

Some of these genes have been implicated in other cancers, such as colon cancer, leukemia and lymphoma. "These genes could soon be new targets for lung cancer treatments," Meyerson said.

The researchers also looked at genetic mutations found among different adenocarcinoma patients. Most cases of lung cancer (90 percent) occur in smokers. Among smokers, there were many more gene mutations than those found in the lung cancer tumors of nonsmokers.

Tumors for smokers had as many as 49 mutations, while none of the nonsmokers had more than five mutations, the researchers reported.

"Our study could achieve a real impact on the care of lung cancer patients," Meyerson said. "It is important to study the role of the mutated genes in the growth and survival of lung cancer cells, which will help us work toward new treatments."

Dr. Norman H. Edelman, chief medical officer of the American Lung Association, called the new research another positive step in understanding cancer and could lead to new therapies.

"The methods of this study are powerful, and the sample is large, thus it is a good study. We can expect more like this," Edelman said. "The genetic basis of cancer is very complex, and this represents another piece of the puzzle. Whether or not finding newly implicated genes will lead to new therapies, as the authors suggest, is, of course, something to be hoped and waited for."

Lung cancer is the leading cause of cancer deaths in the United States and around the world. More than 1 million people worldwide die of lung cancer each year, including more than 160,000 people in the United States. Lung adenocarcinoma, the most frequently diagnosed form of
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