Navigation Links
Researchers Find Gene Location That Gives Rise to Neuroblastoma, an Aggressive Childhood Cancer
Date:5/7/2008

--First Finding of Origin of a Puzzling Pediatric Tumor--

PHILADELPHIA, May 7 /PRNewswire-USNewswire/ -- Using advanced gene-hunting technology, an international team of researchers has for the first time identified a chromosome region that is the source of genetic events that give rise to neuroblastoma, an often fatal childhood cancer.

The investigators found that the presence of common DNA variations in a region of chromosome 6 raises the risk that a child will develop a particularly aggressive form of neuroblastoma, a cancer of the peripheral nervous system that usually appears as a solid tumor in the chest or abdomen. Neuroblastoma accounts for 7 percent of all childhood cancers, but due to its aggressive nature, causes 15 percent of all childhood cancer deaths.

"Until now we had very few clues as to what causes neuroblastoma," said pediatric oncologist John M. Maris, M.D., who led the study at The Children's Hospital of Philadelphia, where he is the director of the Center for Childhood Cancer Research. "Although there is much work to be done," added Maris, "understanding this cancer's origin provides a starting point for developing novel treatments." The study team reported its findings in today's Online First version of the New England Journal of Medicine.

Neuroblastoma is the most common solid cancer of early childhood and has long been known to include subtypes that behave very differently. Some cases strike infants but spontaneously disappear with minimal treatment, while other cases in older children may be relentlessly aggressive from the start.

Researchers at Children's Hospital and colleagues in the multicenter Children's Oncology Group have for decades analyzed tumors for characteristics such as amplified levels of a cancer-causing gene and deletions of chromosome material. They used those tumor peculiarities to classify neuroblastoma into risk levels that guide oncologists toward the most appropriate
'/>"/>

SOURCE The Children's Hospital of Philadelphia
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine news :

1. Researchers Publish Genome Sequence for Duck-Billed Platypus
2. UC San Diego researchers target tumors with tiny nanoworms
3. Researchers Find Lubricant Doesnt Hinder Fertility
4. MGH researchers report successful new laser treatment for vocal-cord cancer
5. Stanford researchers synthesize compound to flush HIV out of hiding
6. World first: researchers develop completely automated anesthesia system
7. Researchers Develop Quick Way to Create Human Antibodies
8. Researchers Tackle HIV From a New Angle
9. Researchers important markers of high risk of type 2 diabetes
10. Cancer researchers receive NIH grant to advance brain tumor therapies from lab to clinical trials
11. Researchers Identify Contaminant in Tainted Heparin
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... The inaugural single day event in Japan will ... Gardens in Tokyo. Clinical data scientists will meet and discuss ... second single day event in China will be ... clinical data scientists attending this event will discuss topics around ... display data collected in clinical studies and beyond. , ...
(Date:9/23/2014)... COLUMBIA, Mo. Infants, vocalizations throughout the first ... crying and cooing to forming syllables and first ... the amount of vocalizations may differ between hearing ... shows that infant vocalizations are primarily motivated by ... infants with profound hearing loss who received cochlear ...
(Date:9/23/2014)... of published studies found that FDG-PET technology is ... disease in regions where infections like histoplasmosis or ... suspicious for cancer could lead to unnecessary tests ... and mortality. , Histoplasmosis and other fungal ... concentrated in bird droppings and are found in ...
(Date:9/23/2014)... World of Home Fitness is committed ... recently, the gym has been raising money to support ... the year, World of Home Fitness has participated in ... Over the summer, World of Home Fitness raised more ... Fitness program, participants helped feed seniors "one rep at ...
(Date:9/23/2014)... As a consumer in today’s world, ... It’s difficult to trust testimonials that are supplied by ... manipulate their customers into saying anything. , Consumer advocacy ... to lack in depth coverage on a particular market ... to fix this issue and focus on exposing the ...
Breaking Medicine News(10 mins):Health News:PhUSE Further Expands its Global Community Into the Asian Region 2Health News:Infant cooing, babbling linked to hearing ability, MU researcher finds 2Health News:Study questions accuracy of lung cancer screens in some geographic regions 2Health News:World of Home Fitness Supports Meals on Wheels 2Health News:Consumer Health Reports Debuts Revolutionary Review Website 2
... for, immunization against diphtheria, tetanus, pertussis, polio and Haemophilus ... ... LYON, France, June 23 Sanofi,Pasteur, the vaccines division of ... Administration (FDA) has licensed Pentacel(R),Diphtheria and Tetanus Toxoids and Acellular ...
... of persistent, recent-onset symptoms linked to ovarian cancer ... quickly and abdominal bloating when combined with the ... ovarian cancer by 20 percent, according to new findings ... online today in CANCER . , Research has ...
... Delivery Unit at The Children,s,Hospital of Philadelphia, the ... birth defects, PHILADELPHIA, June 22 Hundreds ... Hospital of Philadelphia for,the 12th Annual Fetal Surgery ... been followed by the Center for Fetal Diagnosis ...
... are struggling with the health fallout caused by a lack ... Most women don,t need a survey to tell them a ... too sluggish to make it through the day with vigor. ... moms, empty-nesters or grandmothers, many -- if not most -- ...
... best in those under 80, could ease expected worldwide shortfall ... blood substitute product called HBOC-201 proved safe and effective in ... reports. , In all, 688 patients, ages 18 and ... unit of blood (about one pint) or an equivalent one ...
... India, June 20 The United States,has provided ... the Children to assist people affected by the ... Shortages have emerged in recent months because the ... rapidly growing rat infestations in,crop-growing areas. With funds ...
Cached Medicine News:Health News:U.S. FDA Licenses Sanofi Pasteur's New Pediatric Combination Vaccine, Pentacel(R) 2Health News:U.S. FDA Licenses Sanofi Pasteur's New Pediatric Combination Vaccine, Pentacel(R) 3Health News:U.S. FDA Licenses Sanofi Pasteur's New Pediatric Combination Vaccine, Pentacel(R) 4Health News:U.S. FDA Licenses Sanofi Pasteur's New Pediatric Combination Vaccine, Pentacel(R) 5Health News:Symptom screening plus a simple blood test improves early detection of ovarian cancer 2Health News:12th Annual Fetal Surgery Family Reunion Gathers Families From Across the U.S. and Canada 2Health News:12th Annual Fetal Surgery Family Reunion Gathers Families From Across the U.S. and Canada 3Health News:So Much to Do, So Little Sleep 2Health News:So Much to Do, So Little Sleep 3Health News:Blood Substitute Found Safe in Large Phase III Trial 2
(Date:9/23/2014)... 2014 Research and ... of the  "Large Volume Wearable Injectors - ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... significant potential for the future. From the ... to the modern-day pre-filled syringes, pen-injectors, needle ...
(Date:9/23/2014)... Rising health concerns, growing ... number of foreign and domestic players in the market ... India   The India Probiotic ... growth potential markets worldwide due to multiple factors such ... youth, changing food consumption patterns, increasing diabetic population, growing ...
(Date:9/23/2014)... , Sept 23, 2014  Vesselon, Inc. today announced ... of Directors, effective September 15, 2014. Dr. Raths, appointment ... its placement agent to market a private preferred Series ... early stroke treatment. "Jurgen,s deep experience across ... a great asset to Vesselon as we develop our ...
Breaking Medicine Technology:Large Volume Wearable Injectors - 2nd Edition 2Large Volume Wearable Injectors - 2nd Edition 3Large Volume Wearable Injectors - 2nd Edition 4Large Volume Wearable Injectors - 2nd Edition 5India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 2India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 3Vesselon Announces Jurgen Raths, MD to Serve on Board of Directors 2Vesselon Announces Jurgen Raths, MD to Serve on Board of Directors 3
... In conjunction with its third quarter 2011 earnings release (expected to ... (NYSE: CVD ) is pleased to invite you to ... live over the Internet on Thursday, November 3, 2011 at 9:00 ... and Slide Presentation When: Thursday, November 3, 2011, 9:00 ...
... YORK, Oct. 5, 2011 More than 40 million ... "age gracefully at home" due to the benefits of ... Virtual Health is a service provider that delivers a ... going beyond healthcare to also include meals, transportation, and ...
Cached Medicine Technology:A New Model of Healthcare is Unveiled, Offering Seniors Control, Independence and Dignity as They Age 2A New Model of Healthcare is Unveiled, Offering Seniors Control, Independence and Dignity as They Age 3
The Shandon Cryotome Manual Cryostat features unique formalin fumigation, ergonomic design and automatic defrost. The microtome is located outside the cryochamber for easy cleaning....
... Specimen Processing System is used for tissue ... routine special stains where heat would accelerate ... during immunohistochemistry staining. , Product Detail ... to meet the growing workload demands. This ...
... is a service that directly connects ... the customers laboratory to the Thermo ... U.S.A., and Runcorn, U.K.* By using ... customer site, high-value support services are ...
... The Shandon Excelsior Tissue Processor ... processor using traditional reagents today. ... and outstanding features to provide ... use, increased productivity, reagent cost ...
Medicine Products: