Navigation Links
Researchers Find Better Way to Deliver Blood Thinner
Date:9/8/2007

New gene-linked formula should stop trial-and-error warfarin dosing

FRIDAY, Sept. 7 (HealthDay News) -- A new gene-based dosing formula for the anti-clotting drug warfarin should make it easier to prescribe the correct dose of the blood thinner, researchers say.

Up to this point, doctors have had to engage in a trial-and-error process over several weeks that left patients at risk of hemorrhaging from low doses or developing blood clots with too-high doses.

"We already knew these genes affected warfarin dosing, but we didn't know how to use that information clinically," researcher Dr. Brian Gage, medical director of Barnes-Jewish Hospital's Blood Thinner Clinic, said in a prepared statement. "But with this study, we've established a simple way to combine these genetic factors with clinical factors in a dosing algorithm."

Gage and colleagues developed the formula based on study participants who had undergone hip replacement or knee surgery. The study team focused on two genes, VKORC1 and CYP2C9, which are known to affect the way warfarin operates inside the body.

Using the new method, physicians head to a Web-based tool to calculate a patient's initial dosage more accurately.

Writing in the September issue of Blood, Gage and colleagues said the calculated dose will cut down on the number of dose changes patients will need before the amount is correct.

The method follows on the heels of an Aug. 16 requirement by the U.S. Food and Drug Administration that labeling for warfarin include information about the effect of the two genes. The FDA also called for studies to determine the correct dosage for people with each genetic variation. This is the first study to address that request.

Warfarin, sold under the brand name Coumadin, prevents blood clots and reduces the risk of stroke in patients with atrial fibrillation, artificial heart valves, deep venous thrombosis and pulmonary emboli. It is also used to prevent clots in people who recently had certain orthopedic surgeries.

More information

To learn more about blood clots, visit Deep Vein Thrombosis: What You Should Know.



-- Madeline Vann



SOURCE: Washington University School of Medicine, news release, Aug. 30, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
4. New Hair in 15 Days Could Now Be A Possibility Say Researchers
5. Researchers at Cornell University as been reported using research fund by false claims
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. Gene researchers make Malaria-resistant mosquito
9. Researchers developed world’s smallest toothbrus
10. Researchers discover receptor cells that can cause epilepsy
11. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... Boca Raton, FL (PRWEB) , ... January 20, 2017 , ... ... supplement development, announced it attended the January ECRM trade show to continue the marketing ... technologically advanced vitamin C supplement, known for providing 400 percent better absorption than traditional ...
(Date:1/20/2017)... ... January 20, 2017 , ... International Protein, a company based ... supplements, announced it attended the January ECRM trade show in Hilton Head, SC. ... who was determined to create a line of products that would elevate her fitness ...
(Date:1/20/2017)... , ... January 20, 2017 , ... “Mary Magdalene: Grace ... mysterious life of the woman who witnessed Jesus Christ firsthand. “Mary Magdalene: Grace is ... who spent her career as an educator interacting with countless women who had little ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... ... vPEP ® Oscillating Positive Expiratory Pressure (OPEP) device, was featured in a study ... Doug Pursley, MEd, RRT-ACCS, FAARC, “Analysis of Three Oscillating Positive Expiratory Pressure ...
(Date:1/20/2017)... (PRWEB) , ... January 20, 2017 , ... “The Land ... brings attention to the issue of world hunger, and shares the simple and achievable ... Brubaker, devoted husband and member of the Fairview Missionary Church in Angola, Indiana where ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... -- Report Details What can be expected ... to grow at the fastest rates? This visiongain report ... opportunities and prospects. Our 190-page report provides 124 ... in the industry and the future market prospects. Our ... all the major categories of the ophthalmic devices market. ...
(Date:1/19/2017)... 19, 2017 This report on the opioid ... scenario of the global market. Large number of chronic ... chronic constipation is a major side effect of consumption ... novel targeted therapy has been prescribed to treat opioid ... targeted medicines, and growing awareness about the therapy are ...
(Date:1/19/2017)... 2017 Accuray Incorporated (Nasdaq: ARAY ... continue to set the bar for excellence in customer ... user satisfaction rating among radiation treatment delivery systems in ... Market Intelligence Briefing™. The most recent ratings trend also ... industry peers for 11 of the past 12 quarters. ...
Breaking Medicine Technology: