Navigation Links
Researchers Find Better Way to Deliver Blood Thinner
Date:9/8/2007

New gene-linked formula should stop trial-and-error warfarin dosing

FRIDAY, Sept. 7 (HealthDay News) -- A new gene-based dosing formula for the anti-clotting drug warfarin should make it easier to prescribe the correct dose of the blood thinner, researchers say.

Up to this point, doctors have had to engage in a trial-and-error process over several weeks that left patients at risk of hemorrhaging from low doses or developing blood clots with too-high doses.

"We already knew these genes affected warfarin dosing, but we didn't know how to use that information clinically," researcher Dr. Brian Gage, medical director of Barnes-Jewish Hospital's Blood Thinner Clinic, said in a prepared statement. "But with this study, we've established a simple way to combine these genetic factors with clinical factors in a dosing algorithm."

Gage and colleagues developed the formula based on study participants who had undergone hip replacement or knee surgery. The study team focused on two genes, VKORC1 and CYP2C9, which are known to affect the way warfarin operates inside the body.

Using the new method, physicians head to a Web-based tool to calculate a patient's initial dosage more accurately.

Writing in the September issue of Blood, Gage and colleagues said the calculated dose will cut down on the number of dose changes patients will need before the amount is correct.

The method follows on the heels of an Aug. 16 requirement by the U.S. Food and Drug Administration that labeling for warfarin include information about the effect of the two genes. The FDA also called for studies to determine the correct dosage for people with each genetic variation. This is the first study to address that request.

Warfarin, sold under the brand name Coumadin, prevents blood clots and reduces the risk of stroke in patients with atrial fibrillation, artificial heart valves, deep venous thrombosis and pulmonary emboli.
'/>"/>

Copyright©2007 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Ecstasy shrinks brain!!-researchers unveil the secrets of MDMA.
4. New Hair in 15 Days Could Now Be A Possibility Say Researchers
5. Researchers at Cornell University as been reported using research fund by false claims
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. Gene researchers make Malaria-resistant mosquito
9. Researchers developed world’s smallest toothbrus
10. Researchers discover receptor cells that can cause epilepsy
11. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... In partnership with Raw Beauty NYC, OC healthcare ... project’s social media efforts. StudioPMG is honored to be a ... of beauty as it applies to disabled women. , ... Baer and Vanessa Silberman, who wanted to create a photo ... Dixon, Wendy Crawford, Susan Solman and Sabrina Cohen later joined ...
(Date:9/19/2014)... September 19, 2014 -- Recent two-generation approaches to ... are receiving increasing attention from researchers, advocates, and ... to enable them to move to jobs that ... early care and education for children, these programs ... However, according to a new report from ...
(Date:9/19/2014)... 2014 As summer vacations end and everyone ... NY now reminds area patients about the reality and impact ... population affected by gum disease, there is simply not an ... 20 years Dr. Krishnan has treated patients with varying degrees ... patients that come in due to common symptoms such as ...
(Date:9/19/2014)... Recently, Top10BestSEOHosting.com has compared many professional ... Web Hosting and Bluehost are the best VPS ... to most people, VPS (Virtual Private Server) is ... into many servers, each of which has the ... dedicated computer,” the manager of Top10BestSEOHosting.com says. ...
(Date:9/19/2014)... and large protein complexes are notoriously difficult to study ... very difficult, if not impossible, to crystallize, but also ... The result is that when a structure can be ... reveals a mosaic-like spread of protein domains that sometimes ... Brunger. (2014), Acta Cryst . D70, 2241-2255; ...
Breaking Medicine News(10 mins):Health News:OC Healthcare Agency StudioPMG Partners with The Raw Beauty Project ™ NYC 2014 2Health News:A two generation lens: Current state policies fail to support families with young children 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 2Health News:New York Periodontist Dr. Prabha Krishnan Now Raises Awareness about the Dangers of Untreated Decay, Gingivitis and Gum Disease During Self-Awareness Month 3Health News:Top10BestSEOHosting.com: JustHost is One of the Best VPS Suppliers in 2014 2Health News:A refined approach to proteins at low resolution 2Health News:A refined approach to proteins at low resolution 3
... LA JOLLA, Calif., Jan. 29 There,s a rumble ... their feet and planting,their behinds on yoga mats and ... World Health Research shows that,74% of Americans have expressed ... A surge in popularity of Pilates, Yoga, Qigong, Meditation, ...
... recurrence and painful side effects, small trial finds , , ... to treating deep vein thrombosis, injecting the clot-busting drug ... the risk of complications and recurrence, a small U.S. ... of blood thinners appears to completely destroy the clots, ...
... Opportunities for the Company, -- Potentially Denotes a Positive Sign ... ... Process, NEW YORK and HAIKOU, China, ... Board: CPHI),which develops, manufactures, and markets generic and brand,bio-pharmaceutical products in ...
... Ind., Jan. 29 , ... Quarter Highlights, -- Net Sales of $1.07 billion represents an increase of 15% ... 15% reported (10% constant currency), -- Diluted EPS were ... period, and $1.18 adjusted, an increase of 16% over the prior year ...
... MS -- Cold and flu season is upon ... year, according to,the Centers for Disease Control. A cold ... in children and the elderly. Early detection,is key, especially ... days,of the infection,s onset., (Photo: http://www.newscom.com/cgi-bin/prnh/20080129/NYTUFNS1 ...
... for blood clots in the legs appears to be safe ... February issue of Radiology. The study found that injecting or ... deep vein thrombosis (DVT) and reduces the risk of subsequent ... clear blood clots rapidly and safely, restoring blood flow in ...
Cached Medicine News:Health News:Are People Asking Their Doctors?: Halo Rejuvenator a Holistic Remedy for Headache, Neck and Shoulder Pain 2Health News:Are People Asking Their Doctors?: Halo Rejuvenator a Holistic Remedy for Headache, Neck and Shoulder Pain 3Health News:Clot-Busting Drug Offers New Approach to DVT 2Health News:Clot-Busting Drug Offers New Approach to DVT 3Health News:China Pharma Holdings, Inc. Receives Chinese SFDA Approval for Generic Bumetanide Injection 2Health News:China Pharma Holdings, Inc. Receives Chinese SFDA Approval for Generic Bumetanide Injection 3Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 2Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 3Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 4Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 5Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 6Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 7Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 8Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 9Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 10Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 11Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 12Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 13Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 14Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 15Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 16Health News:Zimmer Reports Fourth Quarter and 2007 Financial Results 17Health News:Flu and Fever Detection Facts for Dr. Mom 2Health News:Flu and Fever Detection Facts for Dr. Mom 3Health News:New therapy effectively treats deep vein thrombosis 2
(Date:9/19/2014)... 19, 2014 Today, iHealth Lab Inc. announced it ... Ltd. for its first institutional round of funding. The ... global reach, accelerate growth and innovation, and invest in ... investment, Xiaomi Ventures will join iHealth,s board of directors, ... and ecommerce. "We are very pleased to ...
(Date:9/19/2014)... 19, 2014  The board of directors of AbbVie ... cash dividend of $0.42 per share.  ... stockholders of record at the close of business on ... a global, research-based biopharmaceutical company formed in 2013 following ... its expertise, dedicated people and unique approach to innovation ...
(Date:9/19/2014)... 2014 Research and Markets has announced ... Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023" ... of this report, the human microbiome market is segmented by ... market is expected to be valued as $294 million in ... 22.3% within the forecast period of 2019-2023. The market is ...
Breaking Medicine Technology:iHealth Raises $25 Million to Fuel Growth and Global Market Share 2Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 2Global Human Microbiome (Diabetes, Obesity, Autoimmune, Cancer, Diarrhea, Mental Disorder) Market - Forecast to 2023 3
... Va., Sept. 20, 2011 Rock Creek Pharmaceuticals, a ... ), announced that on September 19, 2011 a utility ... Office ("PTO"). This utility patent application is based on ... various products containing anatabine and the administration of anatabine ...
... Sept. 20, 2011 /PRNewswire-Asia/ -- Chindex International, Inc. (NASDAQ: ... providing health care services in China through the operations ... care hospitals and affiliated ambulatory clinics, today announced that ... to be held October 13-14, 2011 at Nomura,s Singapore ...
Cached Medicine Technology:Rock Creek Pharmaceuticals Discloses Further Anatabine Patent Filing 2Rock Creek Pharmaceuticals Discloses Further Anatabine Patent Filing 3Rock Creek Pharmaceuticals Discloses Further Anatabine Patent Filing 4
Provides the security of braided polyester suture and ease of an automated knot for vascular closure of 5-8Fr....
The ACE Alera clinical chemistry system serves a wide variety of chemistry diagnostic needs with the power of a large floor model analyzer in an easily integrated and economizing compact footprint of...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: