Navigation Links
Researchers Find 3 Genes Linked to Esophagus Disorders
Date:7/26/2011

TUESDAY, July 26 (HealthDay News) -- Mutations in three genes have been found to be more common among people with disorders of the esophagus, including esophageal cancer and Barrett esophagus (a complication of gastroesophageal reflux disease), a new study shows.

The findings could help identify those at greater risk for these conditions and lead to improved treatments, researchers from the Cleveland Clinic said in the report published in the July 27 issue of the Journal of the American Medical Association.

"Finding predisposition genes may improve premorbid risk assessment, genetic counseling and management," Dr. Charis Eng and colleagues wrote.

The developments are significant because in the United States and Europe, cases of esophageal cancer have surged 350 percent over the past 40 years and Barrett esophagus (which is believed to precede the cancer) affects 10 percent of the population, the authors explained in a journal news release.

In conducting the study, the investigators pinpointed three major genes -- known as MSR1, ASCC1 and CTHRC1 -- associated with both esophageal cancer and Barrett esophagus.

Out of 116 patients analyzed, mutations in these three genes were found in 13 people. "These three genes together accounted for 11 percent of our cases, reflecting what is normally considered a moderate- to high-penetrance genetic load for a disease," Eng's team wrote.

The study authors pointed out, however, that further research is needed to support the findings. They added that larger studies might also be needed to explore how these genes can be used to diagnose or assess patients' risk for disorders of the esophagus.

More information

The U.S. National Institutes of Health provides more information on esophagus disorders.

-- Mary Elizabeth Dallas

SOURCE: JAMA/Archives, news release, July 26, 2011


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. UBC researchers create more powerful lab-on-a-chip for genetic analysis
2. UNC researchers identify seventh and eighth bases of DNA
3. BUSM/BMC researchers awarded $3.5 million grant from the NIDA
4. U of M researchers improve method to create induced pluripotent stem cells
5. URMC researchers exploring keys to melanoma progression
6. University of Maryland researchers discover possible drug targets for common non-Hodgkins lymphoma
7. RI Hospital researchers find common test may be unnecessary for bariatric surgery candidates
8. Over half of Alzheimers cases may be preventable, say researchers
9. Penn researchers find neural signature of mental time travel
10. Researchers identify how a gene linked to both Alzheimers disease and type 2 diabetes works
11. NYU researchers develop compound to block signaling of cancer-causing protein
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Find 3 Genes Linked to Esophagus Disorders
(Date:2/24/2017)... , ... February 24, 2017 , ... With ProGlass Prism ... Pro X . Users have total control over position, rotation, distortion, edge softness, edge ... within Final Cut Pro X. , With ProGlass Prism users are given the tools ...
(Date:2/24/2017)... Farifax, VA (PRWEB) , ... February 24, 2017 , ... ... winners for excellence in radiology marketing programs at the annual Building Better ... the Worthington Renaissance Fort Worth Hotel in Fort Worth, Texas. Nine awards are given ...
(Date:2/23/2017)... ... February 23, 2017 , ... On February 22, 2017 the ... to withdraw previous guidance issued by the Obama Administration requiring schools to ... May 2016 by the Obama Administration came in response to a growing number ...
(Date:2/23/2017)... ... February 23, 2017 , ... Los Angeles-based weight loss surgeon Michael Feiz, M.D., ... From Not to Hot,” which will begin airing on February 24, 2017. The show ... from the 2012 reality television series, “Here Comes Honey Boo Boo.” The earlier series ...
(Date:2/23/2017)... ... , ... Dr. David Mahon leads Siena Dental, a comprehensive dental practice located ... 2017 Top Patient Rated Henderson Dentist by Find Local Doctors earlier this ... and dentists who have earned high ratings and superior patient reviews from multiple credible ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... , Feb. 23, 2017 Report analyzes the ... provides separate comprehensive analytics for the US, Canada ... , Asia-Pacific , Latin ... forecasts are provided for the period 2015 through 2022. Also, ... data and analytics are derived from primary and secondary research. ...
(Date:2/24/2017)... ITL Limited, ( ASX : ITD ), une société de ... excellents résultats semestriels clos le 31 décembre 2016 par ... « Résultats et mise à jour sur la croissance biomédicale ... Faits marquants Bénéfice ... hausse de 104 %) Bénéfice par action ...
(Date:2/24/2017)... -- This report analyzes the worldwide markets for Chiral Technology ... Products: Intermediates, Analytical, and Others. The End Use markets ... The report provides separate comprehensive analytics for the US, ... , and Rest of World. Annual estimates and forecasts ... a six-year historic analysis is provided for these markets. ...
Breaking Medicine Technology: