Navigation Links
Researchers Discover a Gene That Is Associated with Obesity
Date:7/19/2013

Washington, USA (PRWEB) July 19, 2013

In an article found on Sciencedaily.com, researchers from the Spanish National Cancer Research Centre (CNIO) discovered the key role of the gene RAP1, a gene that protects telomeres – the ends of chromosomes – and it’s link to obesity.

"We still don't know what evolutionary significance to attach to it, but it is at the very least interesting that a telomere gene is related to obesity," says Maria Blasco, CNIO director and co-author of the study published today in the journal Cell Reports.

RAP1 forms part of what’s called the shelterin complex, which is a group of proteins that makes up the protective hood of telomeres. Telomeres are found at the end of the chromosomes that shortens with each celluar division and thus, measures the ageing of the organism. Studies show that RAP1 is not essential for the survival of the organism, but that won’t mean it doesn’t have its importance in the body. When comparing the genomes of different species, it was shown that RAP1 is the most conserved shelterin of all. RAP1 has not changed at all, despite the long history of evolutionary change. But what is the role in the organism?

The researchers at CNIO found that RAP1 is also present in the rest of the chromosome, not just at in telomeres. They felt that it acts as a regulation for the action of the other genes. CNIO researchers created a lineage of mice without RAP1, and found that they had a model for obesity. In other words, mice lacking RAP1 will gain more weight than those with the RAP1 gene.

"Mice -- especially female mice -- without RAP1 do not eat more, but do gain weight. They suffer from metabolic syndrome, accumulate abdominal fat and present high glucose and cholesterol levels, amongst other symptoms," says Paula Martínez, first-author of the study.

The importance of RAP1 is the regulation of genes involved in metabolism. In the next step, researchers will study if RAP1 also plays a role in human obesity. "This discovery adds an element to the obesity equation, and opens up a possible new link between metabolic dysfunction and ageing, via a protein present in telomeres," says Blasco.

For those who are in need of help in order to control weight in those who are obese, overweight, Prescopodene Nutritionals have found just a supplement that can help fight weight gain.

They discovered a natural diet supplement called Prescopodene which been found to help reduce weight in overweight and obese individuals. The diet pill was recently named one of the “Best Diet Pills of 2012” by The Diet Pill Review, an independent industry review group – Prescopodene earned perfect scores for safety, effectiveness, and speed of results.

About Prescopodene Nutritionals:

Prescopodene Nutritionals is helping people around the world lose weight, improve their health, and maximize their daily satisfaction. With a catalog of healthy living products that is winning awards and recognition, the company is delivering all-natural weight loss solutions to customers around the globe. Prescopodene Nutritionals is based in Australia and the USA.

Read the full story at http://www.prweb.com/releases/2013/7/prweb10920559.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related medicine news :

1. Researchers report a complete description of gene expression in the human retina
2. Researchers Find That Setting Weight Loss Ranges Are More Beneficial than Specifics, Making Weight Loss Via Supplements Like Prescopodene More Likely
3. Single dose of ADHD drug can reduce fall risk in older adults -- Ben-Gurion U researchers
4. UCLA researchers find link between intestinal bacteria and white blood cell cancer
5. Cancer researchers discover how BRCA1 mutation starts breast, ovarian cancers
6. Notre Dame researchers offer new insights on cancer cell signaling
7. Use redistricting maps to make organ allocation more equitable, Johns Hopkins researchers advocate
8. Sanford-Burnham researchers develop novel nanoparticle to deliver powerful RNA interference drugs
9. Researchers investigate mechanism of Alzheimers therapy
10. Researchers pinpoint sources of fibrosis-promoting cells that ravage organs
11. Researchers use immunocytochemistry to determine ALK status
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department ... in recognition of their exemplary accomplishments in worksite health promotion. , The Wellness at ... Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one of 42 ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may suffer ... unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To avoid ... healthy coping following a traumatic event. , Trauma sufferers tend to feel a range ...
(Date:6/24/2016)... Texas (PRWEB) , ... June 24, 2016 , ... ... International Conference and Scientific Sessions in Dallas that it will receive two significant ... of the grants came as PHA marked its 25th anniversary by recognizing patients, ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
(Date:6/24/2016)... Georgia (PRWEB) , ... June 24, 2016 , ... ... awards today at the Clinical Decision Making in Emergency Medicine conference in Ponte ... have authored journal articles published in Emergency Medicine Practice and Pediatric ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- MedSource announced today that it has selected Datatrial,s ... choice.  This latest decision demonstrates MedSource,s commitment to ... by offering a state-of-the-art electronic data capture (EDC) ... the EDC platform of choice in exchange for ... long been a preferred EDC platform by our ...
(Date:6/23/2016)... June 23, 2016 Research and ... Excipients Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), ... Topical, Coating, Parenteral) - Global Forecast to 2021" ... The global pharmaceutical excipients market is projected ... CAGR of 6.1% in the forecast period 2016 to ...
(Date:6/23/2016)... Research and Markets has announced the ... 2016 - Forecast to 2022" report to their offering. ... up to date financial data derived from varied research sources ... with potential impact on the market during the next five ... comprises of sub markets, regional and country level analysis. The ...
Breaking Medicine Technology: