Navigation Links
Researchers Develop Stem Line With Sickle Cell Mutation
Date:5/29/2008

Technique could allow scientists to more quickly screen models for drugs to treat diseases

THURSDAY, May 29 (HealthDay News) -- Using a faster and more efficient method of reprogramming adult stem cells to an embryonic stem cell-like state, Johns Hopkins researchers developed a human stem cell line containing the mutation associated with sickle cell anemia.

"We hope our new cell lines can open the door for researchers who study diseases like sickle cell anemia that are limited by the lack of good experimental models," Linzhao Cheng, an associate professor of gynecology and obstetrics, medicine and oncology, and a member of the Johns Hopkins Institute for Cell Engineering, said in a prepared statement.

The researchers found that using a viral protein called SV40 large T antigen, along with four genes known to trigger adult cells to reprogram into embryonic-like stem cells, resulted in reprogramming within 12 to 14 days, compared to three to four weeks when large T wasn't used.

"Not only did T speed up reprogramming, we also found that it increases the total number of reprogrammed cells, which is great because often in reprogramming, not all cells go all the way," Cheng said.

Using this new method, the researchers created embryonic-like stem cells that contained the mutation that causes sickle cell anemia.

"One challenge to studying blood diseases like sickle cell anemia is that blood stem cells can't be kept alive for very long in the lab, so researchers need to keep returning to patients for more cells to study," Cheng said. "Having these new cell lines available might enable some bigger projects, like screening for potential drugs."

The study was published online May 29 in the journal Stem Cells.

More information

The U.S. National Institutes of Health has more about stem cells.



-- Robert Preidt



SOURCE: Johns Hopkins, news release, May 29, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... , ... January 20, 2017 , ... A new partnership ... items they no longer use or need, from clothes to couches to dressers and ... items and take them to the nearest Goodwill donation center through February 28th. ...
(Date:1/20/2017)... ... 20, 2017 , ... Lice Troopers, the lice removal company based in South ... since the holiday season. , “It happens every year around this time,” says ... taking photos, which is the head-to-head gateway that lice need to spread.” , As ...
(Date:1/20/2017)... New York, NY (PRWEB) , ... January 20, ... ... drinks – VW+ 001 and its sugar-free alternative VW+ 002. The drinks have ... the body with optimal conditions to perform during your workout. , After a ...
(Date:1/20/2017)... Farmville, NC (PRWEB) , ... January 20, 2017 ... ... the vPEP ® Oscillating Positive Expiratory Pressure (OPEP) device, was featured in ... article by Doug Pursley, MEd, RRT-ACCS, FAARC, “Analysis of Three Oscillating Positive ...
(Date:1/20/2017)... ... ... Miracle Man: Against All Odds”: an inspiring affirmation of God’s work. “God's Miracle ... son of Minister Delores Pinnock and a Jamaican native who lives in Kingston and ... up in bed, I felt a pounding headache. It was like a drum beating ...
Breaking Medicine News(10 mins):
(Date:1/21/2017)... -- Faruqi & Faruqi, LLP, a leading national securities law firm, ... KMPH ) of the federal securities class action ... and underwriters of the Company,s April 16, 2015 Initial Public ... The lawsuit has been filed in the ... County on behalf of all those who acquired ...
(Date:1/20/2017)... Jan. 20, 2017  Ethicon Endo-Surgery, Inc. ... Medical Products, Inc., a privately held medical ... electrosurgical tools used in operating rooms worldwide. ... Ethicon,s* advanced energy devices with Megadyne,s innovative ... step forward in Ethicon,s goal to deliver ...
(Date:1/20/2017)... BUFFALO, N.Y. , Jan. 20, 2017 /PRNewswire/ ... health programs, has announced the launch of an ... to new guidelines on opioids and helps stem ... Opioids are often prescribed to treat chronic non-cancer ... disease) despite serious risks and lack of evidence ...
Breaking Medicine Technology: