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Researchers Develop Blood Test for Depression
Date:4/17/2012

By Carina Storrs
HealthDay Reporter

TUESDAY, April 17 (HealthDay News) -- Researchers have developed a blood test that could one day help diagnose teens with depression.

To create the test, researchers identified 26 potential biological markers for depression. Then they tested the markers in a small group of teens and found that a handful of them could distinguish the teens with major depression from those without depression.

The research was published April 17 in the journal Translational Psychiatry.

"I think it would be more accurate to diagnose depression with a blood test," said study author Eva Redei, a professor of psychiatry at Northwestern University Feinberg School of Medicine. The biomarkers now have to be studied in a larger group of teens, she added.

Currently the diagnosis for depression is subjective and involves doctors talking with patients about their moods. The evaluation is especially tricky in teens because this is a trying time emotionally to start with, Redei said.

Having an objective diagnosis that relies on biomarkers could also make it an easier diagnosis for teens to hear and ease some of the stigma associated with depression.

"It would bring this disease into the same family of other serious illnesses," Redei said. "It would be much more difficult for somebody to say, 'Just snap out of it' or 'Get yourself together.'"

Between 17 percent and 25 percent of adolescents and young adults experience depression, according to study background information. Teens who develop depression have a worse prognosis, marked by illness, substance abuse and suicidal behavior, compared to people who are diagnosed later in life.

The current study involved 28 white and black teens in the Chicago area. Half of the teens had depression.

The researchers compared the levels of the 26 potential biomarkers in blood samples from the teens and found that 11 of them were present at higher or lower levels among the teens with depression.

In addition, they found that 18 of the biomarkers could accurately predict whether teens with depression also had an anxiety disorder.

In a clinical setting, a screening test for depression would involve a panel of biomarkers, Redei explained. Some of them would give the doctor a yes/no answer about whether the teen could have depression and should be further evaluated, while others could reveal information about the depression and how to treat it, such as its severity and whether it is accompanied by anxiety.

"The hope is that not only can these tests identify who is depressed, but they also potentially discriminate between different types of depression," Redei said.

But first Redei's group has to determine whether their biomarkers are accurate in a large group of teens representing a range of racial backgrounds and from different areas of the country. They are now beginning these studies.

Larger studies will tell us a lot about how useful these biomarkers could be, said Dr. Sheldon Preskorn, a professor of psychiatry at the University of Kansas School of Medicine-Wichita. Anytime you test a number of potential biomarkers on a small group of people you are going to find some biomarkers that look clinically important, he added.

But having a screen to help identify who has depression could be hugely helpful, Preskorn said. "This kind of approach is somewhat the holy grail of psychology."

There are as yet no biomarkers available for diagnosing depression at any age.

Redei's group is also testing the biomarkers in adults. Although it is too soon to tell for sure, she thinks that some will end up being helpful for diagnosing depression in adults.

The group originally identified the set of 26 candidate biomarkers by studying rats with conditions that mimic depression in humans. And like in humans, the condition in rats is linked either to genetic or environmental factors.

The researchers looked in these animals at a type of molecule called a transcript, which is an intermediate molecule between a gene and its corresponding protein. Differences in the level of transcripts indicate changes in gene expression.

They found 11 transcripts that were different in the blood and brain of animals that were bred to be in a perpetual state of depression compared to normal animals. In addition, they found 15 transcripts that increased or decreased in groups of rats with environment-induced depression.

Altogether the changes that the researchers found were in genes that were "most unexpected," Redei said, adding that, "This just characterized how little we know about depression."

The discovery of these biomarkers gives researchers a new list of targets to pursue as potential antidepressants, Redei said.

Having a reliable blood-based diagnostic for depression could also open the door to treating people before symptoms appear, Preskorn said. "You might want to look at high-risk populations, like if you have a family history of depression."

This approach is similar to how doctors manage other conditions like heart disease, Preskorn said. "If you know that a person has high cholesterol and high lipids, then you don't wait till the person develops atherosclerosis to start the statin drug."

More information

You can learn more about diagnosing depression at the U.S. National Institute of Mental Health.

SOURCES: Eva Redei, Ph.D., professor, psychiatry and behavioral sciences, Northwestern Medicine, Chicago; Sheldon Preskorn, M.D., professor, psychiatry, University of Kansas-Wichita School of Medicine and chief scientific officer, clinical trial unit, University of Kansas Medical Center; April 17, 2012, Translational Psychiatry


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