Navigation Links
Researchers Detect Blood-Clotting Mechanism
Date:6/4/2009

Finding could help those with potentially deadly conditions

THURSDAY, June 4 (HealthDay News) -- Ever wonder how your blood miraculously stops flowing and forms a scab after a cut? Researchers have now pinpointed the mechanism down to the molecular level.

"The human body has an incredible ability to heal from life's scrapes and bruises," study co-author Wesley P. Wong, a principal investigator at the Rowland Institute at Harvard University, said in a university news release.

"A central aspect of this response to damage is the ability to bring bleeding to an end, a process known as hemostasis," Wong said. "Yet regulating hemostasis is a complex balancing act."

If people have too much hemostatic activity, they can develop an excess of blood clots, resulting in thrombosis, which is a potentially deadly condition. On the other hand, if there is too little hemostatic activity, people could bleed to death, according to background information in the news release.

To achieve and maintain the right hemostatic balance, the body has a feedback system controlled by miniscule forces in the circulation system. The forces are applied to the highly-sensitive A2 domain of the blood-clotting protein called von Willebrand factor (VWF), which acts as a "force sensor," the researchers explained.

By manipulating single molecules, the researchers found that the tiniest force causes A2 molecules to unfold and lose much of their complex, three-dimensional organization. After the unfolding, the enzyme ADAMTS13 comes into play. The enzyme cuts the molecule, hence controlling the size of the blood clot, according to the study, in the June 5 issue of Science.

"In the body, these cutting events decrease hemostatic potential and also enable blood clots to be trimmed in size," Wong said. "The system is so finely tuned that the A2 shear sensor is able to regulate the size of VWF within the bloodstream, maintaining the optimal size for responding properly to traumas."

To manipulate molecules, the researchers used "optical tweezers" developed in Wong's lab, which can apply miniscule forces to individual molecules while observing tiny changes in their length.

A better understanding of the mechanism of blot clotting could lead to new treatments for injuries or bleeding disorders, such as type 2A von Willebrand disease, the researchers noted.

More information

The American Academy of Family Physicians has more on excessive blood clotting.



-- Jennifer Thomas



SOURCE: Harvard University, news release, June 4, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Detect Blood-Clotting Mechanism
(Date:12/5/2016)... ... December 05, 2016 , ... ... Rejuvenation" at the 2016 Anti-Aging & Beauty Awards at The Aesthetic & ... & Anti-aging Medicine European Congress (AMEC) brings together the industry’s leading scientific ...
(Date:12/4/2016)... ... December 02, 2016 , ... Metabolic Code (MC) ... nutraceuticals and help doctors more efficiently manage their practice. Power2Practice is adding ... platform for Integrative and Functional Medicine. , The Metabolic Code platform provides ...
(Date:12/4/2016)... ... 2016 , ... While James Earl Jones is known for myriad roles on ... called "Front Page". One of the forthcoming episodes examines mammogram techniques; a very important ... large part due to early detection. Like any other disease, treatments have a much ...
(Date:12/4/2016)... Viejo, California (PRWEB) , ... December 04, 2016 ... ... lower third presets that have new attractive animation styles with unique displacement design ... Displace features 30 pre-animated lower third designs. Choose from a variety of design ...
(Date:12/4/2016)... (PRWEB) , ... December 04, 2016 , ... Responsible dental ... One must brush properly to achieve optimal results. This important necessity inspired an inventor ... need for a way to ensure that people break or avoid bad techniques of ...
Breaking Medicine News(10 mins):
(Date:12/5/2016)...  Wellbridge Health and Gateway Health proudly announce a dynamic ... and Medicaid plan members with specific high risk needs. ... of this group of consumers, Wellbridge combines technology and population ... insight into members, daily behaviors and lifestyle. ... , , ...
(Date:12/5/2016)... , Dec. 5, 2016  New research ... ) Research Institute and the U.S. Department of ... Secretary for Preparedness and Response (ASPR), published online ... that automated pharmacy notifications encourage patients with chronic ... natural disaster. The study also affirms that public-private ...
(Date:12/5/2016)... VEGAS , Dec. 5, 2016  BD (Becton, ... leading global medical technology company, will demonstrate an enhanced ... medication management technologies, including the company,s leading Pyxis™ and ... Health-System Pharmacists (ASHP) 2016 Midyear Meeting being held ... 4-8. While national data show that approximately ...
Breaking Medicine Technology: