Navigation Links
Researchers Design Promising Cancer Drug
Date:3/7/2008

It activates p53 tumor-suppressor function without causing DNA damage

FRIDAY, March 7 (HealthDay News) -- A drug that targets a protein interaction involved in many types of cancer has been created by University of Michigan researchers.

In cell cultures, the small-molecule inhibitor MI-219 was highly effective at preventing the tumor-suppressor function of the protein p53 from being blocked in the presence of a protein called MDM2.

In animals with human cancer, MI-219 completely inhibited tumor growth and appeared to cause no severe side effects.

"For more than 10 years, scientists have searched for ways to block p53 inhibition, but with little success. Our study clearly shows that this can be done," study author Shaomeng Wang, a professor of medicine at the U-M Medical School and co-director of the molecular therapeutics program at the U-M Comprehensive Cancer Center, said in a prepared statement.

The research was published online this week in the Proceedings of the National Academy of Sciences.

Clinical trials of the drug could begin by the end of 2008. If the drug proves safe and effective in humans, it could potentially be used to treat many kinds of cancer, according to the researchers.

In almost all types of human cancer, p53 is inactivated. About half the time, this is because the protein MDM2 binds to p53 and inhibits the tumor-suppressor function of p53. In other cases, p53 dysfunction is due to a missing or mutated gene.

"Many traditional cancer drugs also activate p53, but they do so by causing DNA damage. They kill not only tumor cells but also normal cells, thus having severe side effects. MI-219 is unique in that it is designed to activate p53 without causing DNA damage, specifically killing tumor cells," Wang said.

The University of Michigan has filed a patent application for MI-219 and its related molecules. The technology has been licensed by
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Case Western Reserve University researchers identify colorectal cancer gene
2. On a roll: MIT researchers devise new cell-sorting system
3. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
4. Researchers control growth rate of replacement blood vessels, tissues
5. New protein discovery helps researchers understand autoimmune diseases
6. UF researchers warn parents about dangers of childhood foot burns
7. UCLA researchers find blood stem cells originate and are nurtured in the placenta
8. UCSF researchers validate new model for breast cancer risk assessment in multiple ethnic groups
9. Einstein researchers discover gene mutations linked to longer lifespans
10. U-M researchers ID promising new cancer drug
11. Researchers identify new genetic marker for breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Design Promising Cancer Drug
(Date:7/13/2014)... 13, 2014 Epidemiologists forecast an increase ... 6MM, from 8,062 diagnosed incident cases in 2013 to ... Growth Rate (AGR) of 4.35%, during the forecast period. ... of diagnosed incident cases of aGVHD in the 6MM, ... the lowest number of diagnosed incident cases of aGVHD, ...
(Date:7/13/2014)... A decreased ability to identify odors might ... disease, while examinations of the eye could indicate ... Alzheimer,s, in the brain, according to the results ... Alzheimer,s Association International Conference 2014 (AAIC 2014) in ... decreased ability to identify odors was significantly associated ...
(Date:7/13/2014)... 13, 2014 Wright & Schulte LLC ... been scheduled in July of 2015, in U.S. District ... are in the discovery process in the South ... is presiding over the multidistrict litigation (MDL). The complaints ... of individuals who allege that they took the statin ...
(Date:7/13/2014)... California (PRWEB) July 13, 2014 Celebrity ... Musico has formed a promotional partnership with Aqua Health ... based Omega-3 EPA supplement . The collaboration was ... a celebrity fitness trainer , actor, model, and ... go-to trainer for A-List celebrities, he has prepared stars ...
(Date:7/13/2014)... July 13, 2014 Hope Palliative & Hospice ... grief support group at the Tamarack Senior Living Community in ... at 10:30 A.M. on the 3rd Wednesdays of every month. ... at the Tamarack Community located at 55 S. Greeley St. ... individuals and there is no cost for the group. ...
Breaking Medicine News(10 mins):Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 2Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 3Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 4Health News:Smell and eye tests show potential to detect Alzheimer's early 2Health News:Smell and eye tests show potential to detect Alzheimer's early 3Health News:Smell and eye tests show potential to detect Alzheimer's early 4Health News:Smell and eye tests show potential to detect Alzheimer's early 5Health News:Smell and eye tests show potential to detect Alzheimer's early 6Health News:Smell and eye tests show potential to detect Alzheimer's early 7Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 2Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 3Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 4Health News:Celebrity Fitness Expert Supports Revolutionary New Health Supplement 2Health News:Hope Hospice Announces Grief Support Group at the Tamarack Senior Living Community 2
... ,Age-Related Macular Degeneration Awareness Month, , , SUNDAY, ... its efforts to educate Americans about age-related macular ... Age-Related Macular Degeneration Awareness Month. , AMD -- ... costs the U.S. economy $570 million a year ...
... A mathematical model that looks at different strategies ... and patient isolation may be effective approaches when ... era of superbugs, such as methicillin-resistant Staphylococcus aureas ... over bacterial infections, this type of modeling, if ...
... BOSTON, Feb. 16, 2008 According to the National ... 80 percent of them women. Because the disease causes ... hip fractures, spinal fractures and a whole host of ... as popularly prescribed Fosamax (alendronate sodium), are a class ...
... finding that out of sight, out of mind can no ... our waters. Substances that we use everyday are turning up ... aquatic life and possibly ourselves. , Derek Muir of ... or so chemicals used commercially in the United States and ...
... Ala., Feb. 15 Cory Watson Crowder &,DeGaris, ... Bayer AG on behalf,of plaintiffs throughout the United ... given Trasylol(R) -- a,Bayer-manufactured drug used to prevent ... called CABG or more commonly bypass).,According to CBS ...
... MADISON, N.J., Feb. 15 Wyeth Consumer,Healthcare, a ... announced that Isma,Benattia, MD, has been named Executive ... Dr. Benattia will lead all,aspects of the consumer ... will drive and prioritize the division,s R&D efforts ...
Cached Medicine News:Health News:Don't Lose Sight of Vision Care, Group Urges 2Health News:Mathematical modeling offers new approaches to fight dual-resistant hospital infections 2Health News:Link between treating osteoporosis with bisphosphonates and incidence of bone necrosis examined 2Health News:New findings on emerging contaminants 2Health News:New findings on emerging contaminants 3Health News:New findings on emerging contaminants 4Health News:New findings on emerging contaminants 5Health News:60 Minutes to Report on Dangers of Trasylol: Cory Watson Crowder & DeGaris Involved in Litigation Against Pharmaceutical Giant Bayer AG 2Health News:Wyeth Consumer Healthcare Names New Head of Global R&D 2
(Date:7/10/2014)... , July 10, 2014  The U.S. Department of ... grant to University Hospitals (UH) Case Medical Center Seidman ... national model aimed at improving care for patients with ... the project will test a unique model developed at ... late-stage disease, significant comorbidities, or demonstrated need for high ...
(Date:7/10/2014)... , July 10, 2014 Yesterday, ... Research,s (Moberg) medical device manufacturing facility. Rep. Kennedy ... advanced neurological monitors facilitate cutting-edge research in neurological ... Kennedy and mental health advocate, Garen Staglin ... dedicated to fostering fundamental changes that will radically ...
(Date:7/10/2014)... Mass. , July 10, 2014  Decision ... of surveyed infectious disease (ID) specialists are willing ... Company,s Orbactiv (oritavancin) for use as OPAT, approximately ... prescribe these agents to their hospital inpatients. However, ... of OPAT patients are initiated on OPAT following ...
Breaking Medicine Technology:University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 2University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 3University Hospitals Case Medical Center Awarded $4.7 Million Grant from U.S. Department of Health and Human Services 4Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3
Straight 22 mm serrated jaws. Ring handle with ratchet lock and dull finish. Overall length 4.9 inches...
Straight shafts with 13 mm crisscross serrated platform with polished finish. Wide serrated handle....
Straight shafts with 6.5 mm tying platform. Crisscross serrated 1mm tips. Scalloped handle with dull finish....
Straight shafts with 1 x 2 teeth. Flat handle with haoles and polished finish. Delicate teeth. Most popular size or model....
Medicine Products: