Navigation Links
Researchers Design Promising Cancer Drug
Date:3/7/2008

It activates p53 tumor-suppressor function without causing DNA damage

FRIDAY, March 7 (HealthDay News) -- A drug that targets a protein interaction involved in many types of cancer has been created by University of Michigan researchers.

In cell cultures, the small-molecule inhibitor MI-219 was highly effective at preventing the tumor-suppressor function of the protein p53 from being blocked in the presence of a protein called MDM2.

In animals with human cancer, MI-219 completely inhibited tumor growth and appeared to cause no severe side effects.

"For more than 10 years, scientists have searched for ways to block p53 inhibition, but with little success. Our study clearly shows that this can be done," study author Shaomeng Wang, a professor of medicine at the U-M Medical School and co-director of the molecular therapeutics program at the U-M Comprehensive Cancer Center, said in a prepared statement.

The research was published online this week in the Proceedings of the National Academy of Sciences.

Clinical trials of the drug could begin by the end of 2008. If the drug proves safe and effective in humans, it could potentially be used to treat many kinds of cancer, according to the researchers.

In almost all types of human cancer, p53 is inactivated. About half the time, this is because the protein MDM2 binds to p53 and inhibits the tumor-suppressor function of p53. In other cases, p53 dysfunction is due to a missing or mutated gene.

"Many traditional cancer drugs also activate p53, but they do so by causing DNA damage. They kill not only tumor cells but also normal cells, thus having severe side effects. MI-219 is unique in that it is designed to activate p53 without causing DNA damage, specifically killing tumor cells," Wang said.

The University of Michigan has filed a patent application for MI-219 and its related molecules. The technology has been licensed by
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Case Western Reserve University researchers identify colorectal cancer gene
2. On a roll: MIT researchers devise new cell-sorting system
3. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
4. Researchers control growth rate of replacement blood vessels, tissues
5. New protein discovery helps researchers understand autoimmune diseases
6. UF researchers warn parents about dangers of childhood foot burns
7. UCLA researchers find blood stem cells originate and are nurtured in the placenta
8. UCSF researchers validate new model for breast cancer risk assessment in multiple ethnic groups
9. Einstein researchers discover gene mutations linked to longer lifespans
10. U-M researchers ID promising new cancer drug
11. Researchers identify new genetic marker for breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Design Promising Cancer Drug
(Date:7/26/2014)... Studio B Dental in Toronto now offers ... Teeth in a Day, gives patients the opportunity to replace ... bright, pearly whites with very little recovery time and no ... feel just like natural teeth, and require no special care ... B Dental is one of the premiere dental experts on ...
(Date:7/26/2014)... July 26, 2014 According to the ... this is a comprehensive bodybuilding program that helps men ... anabolic steroids . The program also instructs men ... cardio. , Vkool reveals in its review that ... that can help men get ripped and jacked at ...
(Date:7/26/2014)... 26, 2014 The birth control safety ... IUD contraceptive of new legal information on the site. ... the number of lawsuits pending for July alleging side ... resource for those using popular prescription drugs and medical ... studies and legal news all in one place, they ...
(Date:7/25/2014)... 2014 Deep Research Report on ... Industry” is a professional and in-depth research report ... market. The report provides basic Laser Scanning Confocal ... definition, classification, application, and industry chain structure ... international market analysis, including China’s domestic market as ...
(Date:7/25/2014)... York, New York (PRWEB) July 25, 2014 ... dismissal and summary judgment in two DePuy Pinnacle hip ... paving the way for the claims to go before ... reports. In an opinion rendered on July 18th, U.S. ... Texas, ruled that the two Plaintiffs’ claims may proceed ...
Breaking Medicine News(10 mins):Health News:Studio B Dental Improves Patient Smiles with All-on-Four Dental Implants 2Health News:Metabolic Enhancement Training Review Exposes Scott Abel's Program for Bodybuilding – Vkool.com 2Health News:Metabolic Enhancement Training Review Exposes Scott Abel's Program for Bodybuilding – Vkool.com 3Health News:DrugNews Adds Latest Court Updates on Mirena IUD Lawsuits 2Health News:Laser Scanning Confocal Microscope Market: 2014 Global, China Manufacturing Bases Analysis Now at DeepResearchReports.com 2Health News:Laser Scanning Confocal Microscope Market: 2014 Global, China Manufacturing Bases Analysis Now at DeepResearchReports.com 3Health News:Laser Scanning Confocal Microscope Market: 2014 Global, China Manufacturing Bases Analysis Now at DeepResearchReports.com 4Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 2Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 3Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 4
... Longs Drug,Stores Corporation (NYSE: LDG ) today ... quarter ended July 31, 2008 of $27.5,million, or ... after-tax,charges, or $0.02 per diluted share, related to ... reserves, a 6.8 percent increase,compared with income from ...
... Aug. 20 /Xinhua-PRNewswire-FirstCall/ -- Tianyin,Pharmaceutical, Co., Inc. (OTC ... modernized traditional Chinese medicine ("TCM") based in,Chengdu, China, ... been,inadvertently changed to OTC BB: TYNPE due to ... being corrected immediately and the Company expects the,stock ...
... BOSTON--A surprise discovery -- that calorie-burning brown fat can be ... the prospect of new ways to fight obesity and overweight, ... Aug. 21 issue of the journal Nature, the ... "good" form of fat -- so called because it burns ...
... evening,Congresswoman Stephanie Tubbs Jones was admitted to Huron ... in Cleveland Heights, Ohio. At,the present time Rep. ... the best care available., Tuesday,s condition followed ... upcoming forum on electoral reform, scheduled for September ...
... of the World,s top entertainers helps introduce new light beer, ... ... Movie star.,Philanthropist. Entrepreneur. Beer drinker?, Everyone knows about Jessica Simpson,s ... has a,passion for working out and making healthy food choices. But ...
... rise, older Americans with limited income and resources find themselves worrying about ... ... August 20, 2008 -- As the costs of healthcare and gas rise, ... how they can afford their next meal. , , ,"I have ...
Cached Medicine News:Health News:Longs Drug Stores Corporation Reports Second Quarter Results 2Health News:Longs Drug Stores Corporation Reports Second Quarter Results 3Health News:Longs Drug Stores Corporation Reports Second Quarter Results 4Health News:Longs Drug Stores Corporation Reports Second Quarter Results 5Health News:Longs Drug Stores Corporation Reports Second Quarter Results 6Health News:Longs Drug Stores Corporation Reports Second Quarter Results 7Health News:Longs Drug Stores Corporation Reports Second Quarter Results 8Health News:Longs Drug Stores Corporation Reports Second Quarter Results 9Health News:Longs Drug Stores Corporation Reports Second Quarter Results 10Health News:Longs Drug Stores Corporation Reports Second Quarter Results 11Health News:Longs Drug Stores Corporation Reports Second Quarter Results 12Health News:Longs Drug Stores Corporation Reports Second Quarter Results 13Health News:Tianyin Pharmaceutical Co., Inc. Announces Trading Symbol Error and Correction 2Health News:Making 'good' fat from muscle and vice versa 2Health News:Making 'good' fat from muscle and vice versa 3Health News:Jessica Simpson Lends Healthy Image for Drink Smart Campaign 2Health News:Jessica Simpson Lends Healthy Image for Drink Smart Campaign 3Health News:Meals or Meds? BenefitsCheckUp Helps Older People Struggling with Food Costs 2
(Date:7/25/2014)... BERWYN, Pa. , July 25, 2014  AMETEK, ... appointment of Kurtis L. Goos as Vice ... Engineered Materials, Interconnects and Packaging (EMIP) Division. ... has extensive general management and business development experience, especially ... to make important contributions to the continued growth and ...
(Date:7/25/2014)... -- Arena Pharmaceuticals, Inc. (NASDAQ: ARNA ) today ... second quarter 2014 financial results before the NASDAQ Global ... same day, Arena will host a conference call and ... Time). The conference call may be ... for international callers. Please specify to the operator that ...
(Date:7/24/2014)... 24, 2014  PTC Therapeutics, Inc. (NASDAQ: ... a webcast conference call to report its second quarter ... company,s business and outlook on Thursday, August 7, 2014 ... market. The call can be accessed ... five minutes prior to the start of the call ...
Breaking Medicine Technology:AMETEK Names Kurtis L. Goos, Vice President & General Manager, Engineered Medical Components 2Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 2Arena Pharmaceuticals to Host Corporate Update and Financial Results Conference Call and Webcast on Friday, August 1 3
Provide 1.5mm protection throughout. Six durable, attractive vinyl coverings are available. Lead glass window factory installed. Larger window available....
Height-Adjustable Mobile X-ray Barrier lets you get close to your patient during special procedures like cardiac cath. 24"H x 36"W viewing panel shields the upper body of one or two people and swivel...
RayShield Frame Mounted Overhead Lead Acrylic Barriers are offered in a choice of three sizes: 60 cm x 80 cm ( 24" x 32") wide, 60 cm x 50 cm( 24" x 20") wide. Lead acrylic windows of 0.5 mm and 1.0 ...
Protective Curtain for Barriers can be used on any of our RayShield® Barriers. Whether they are ordered with the barrier or as a retrofit, RayShield Protective Curtains are easy to install with s...
Medicine Products: