Navigation Links
Researchers Define Mechanism of Methamphetamine Addiction
Date:4/9/2008

Changes in brain's dopamine levels could point to more effective treatments of drug abuse

WEDNESDAY, April 9 (HealthDay News) -- Long-term changes in the brain's dopamine-releasing machinery may explain why methamphetamine addiction is so strong, U.S. researchers say.

Dopamine is one of the brain's major neurotransmitters.

The research team, led by Nigel Bamford, of the University of Washington, Seattle, treated mice with methamphetamine and monitored how extended exposure to the drug affected dopamine levels. The researchers focused on the dopamine machinery in the brain's corticostriatal region, which is believed to contain the "habit" circuitry that plays a major role in the compulsive drug seeking seen in people addicted to methamphetamine and amphetamine.

Long-term exposure to methamphetamine caused a depression of the synaptic dopamine machinery in the corticostriatal region that lasted for months after the mice were no longer given the drug. However, a dose of methamphetamine reversed the depressive effects on the synaptic dopamine machinery.

The researchers also found that the drug produced its long-term effect by altering specific types of receptors for dopamine and another neurotransmitter called acetylcholine.

They concluded that the mechanism they identified "might provide a synaptic basis that underlies addiction and habit learning and their long-term maintenance."

The findings, which were published in the April 10 issue of the journal Neuron, could help lead to more effective treatments for addiction to methamphetamine and related drugs.

In a preview of the research article in the same issue of Neuron, Jeremy Day and Regina Carelli suggested that methamphetamine's effects on the brain discovered by Bamford and his colleagues might disrupt the normal machinery for learning in the brain, "leading to aberrant reward processing and action selection. If so, the discovery of methods to reverse this plasticity may be a promising avenue for addiction treatment."

More information

The U.S. National Institute on Drug Abuse has more about methamphetamine.



-- Robert Preidt



SOURCE: Cell Press, news release, April 9, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... Michigan (PRWEB) , ... May 01, 2016 , ... Serenity ... approach to rehabilitation, has produced a new video that focuses on one of the ... their recent sessions and clips from interviews with a participating patients and the Yoga ...
(Date:4/30/2016)... ... April 30, 2016 , ... ... President and CEO of EMED, today signed a multifaceted agreement which will allow ... the Northern Caribbean University Department of Natural and Applied Sciences, Allied Health and ...
(Date:4/29/2016)... ... April 30, 2016 , ... Mercy College is expanding ... The following programs will be expanding due to high demand: Master of Business Administration ... will begin this summer. , School of Business Graduate Program Chair Dr. ...
(Date:4/29/2016)... ... April 29, 2016 , ... Our bodies are bombarded ... to confront and deal with these stressors is to adopt a more healthful diet, ... for you. Risa Groux, a certified Holistic Nutritionist and the creator of the Newport ...
(Date:4/29/2016)... ... April 29, 2016 , ... Conditions were ideal for Global ... Park on Sunday, with sunny skies, a light breeze and temperatures in the 60s. ... , The 5k Run and Walk and 1-mile walk were held to increase ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... NEW YORK , April 28, 2016 ... of online consumer insights on healthcare, announced today that ... in their report Cool Vendor in Life Sciences, ... , April 15, 2016.  The report focuses on life-science- ... to gain insight from patients and doctors, confirm medication ...
(Date:4/28/2016)... April 28, 2016   Acsis , a leading ... leading IT market research and advisory firm IDC has ... IDC MarketScape: Worldwide Pharmaceutical Track and Trace Software 2016 ... provides an assessment of the capabilities and business strategies ... software market. Logo - http://photos.prnewswire.com/prnh/20160427/360791LOGO ...
(Date:4/27/2016)...  Hologic, Inc. (Nasdaq: HOLX ) ... fiscal second quarter ended March 26, 2016.  GAAP ... 41.2%, and non-GAAP diluted EPS of $0.47 increased ... a reported basis, and 6.3% on a constant ... good quarter, highlighted by 14.6% growth in non-GAAP ...
Breaking Medicine Technology: