Navigation Links
Researchers Define Mechanism of Methamphetamine Addiction
Date:4/9/2008

Changes in brain's dopamine levels could point to more effective treatments of drug abuse

WEDNESDAY, April 9 (HealthDay News) -- Long-term changes in the brain's dopamine-releasing machinery may explain why methamphetamine addiction is so strong, U.S. researchers say.

Dopamine is one of the brain's major neurotransmitters.

The research team, led by Nigel Bamford, of the University of Washington, Seattle, treated mice with methamphetamine and monitored how extended exposure to the drug affected dopamine levels. The researchers focused on the dopamine machinery in the brain's corticostriatal region, which is believed to contain the "habit" circuitry that plays a major role in the compulsive drug seeking seen in people addicted to methamphetamine and amphetamine.

Long-term exposure to methamphetamine caused a depression of the synaptic dopamine machinery in the corticostriatal region that lasted for months after the mice were no longer given the drug. However, a dose of methamphetamine reversed the depressive effects on the synaptic dopamine machinery.

The researchers also found that the drug produced its long-term effect by altering specific types of receptors for dopamine and another neurotransmitter called acetylcholine.

They concluded that the mechanism they identified "might provide a synaptic basis that underlies addiction and habit learning and their long-term maintenance."

The findings, which were published in the April 10 issue of the journal Neuron, could help lead to more effective treatments for addiction to methamphetamine and related drugs.

In a preview of the research article in the same issue of Neuron, Jeremy Day and Regina Carelli suggested that methamphetamine's effects on the brain discovered by Bamford and his colleagues might disrupt the normal machinery for learning in the brain, "leading to aberrant reward processing and action selection. If so, the discovery of methods to reverse this plasticity may be a promising avenue for addiction treatment."

More information

The U.S. National Institute on Drug Abuse has more about methamphetamine.



-- Robert Preidt



SOURCE: Cell Press, news release, April 9, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin ... injury. Recently, he has implemented orthobiologic procedures as a method for treating his ... of the first doctors to perform the treatment. Orthobiologics are substances that orthopaedic ...
(Date:6/24/2016)... Marne, Michigan (PRWEB) , ... June 24, 2016 , ... ... To deal with these feelings, many turn to unhealthy avenues, such as drug or ... Center of Marne, Michigan, has released tools for healthy coping following a traumatic event. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. ... The attorneys chosen by their peers for this recognition are considered among the top ... Shareholders received special honors as members of this year’s Legal Elite Hall of Fame: ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are ... Code Talker Award, an essay contest in which patients and their families pay tribute ... presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital ... area economy by obtaining investment capital for emerging technology companies. SCP has ... have already resulted in more than a million dollars of capital investment for ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Revolutionary ... Oticon , industry leaders in advanced audiology ... of Oticon Opn ™, the world,s first internet ... possibilities for IoT devices.      (Photo: ... introduces a number of ,world firsts,: , ...
(Date:6/23/2016)... 2016 Research and Markets has ... Global Analysis (United States, China, Japan, Brazil, United Kingdom, ... their offering. Surgical ... business planners, provides surgical procedure volume data in a ... an in-depth analysis of growth drivers and inhibitors, including ...
(Date:6/23/2016)... WASHINGTON , June 23, 2016  The ... Pharmaceuticals has joined the health policy research organization ... Steven Romano , MD, senior vice president and ... his company,s representative on the NPC Board of ... are pleased that Mallinckrodt has joined us in ...
Breaking Medicine Technology: