Navigation Links
Researchers Define Mechanism of Methamphetamine Addiction

Changes in brain's dopamine levels could point to more effective treatments of drug abuse

WEDNESDAY, April 9 (HealthDay News) -- Long-term changes in the brain's dopamine-releasing machinery may explain why methamphetamine addiction is so strong, U.S. researchers say.

Dopamine is one of the brain's major neurotransmitters.

The research team, led by Nigel Bamford, of the University of Washington, Seattle, treated mice with methamphetamine and monitored how extended exposure to the drug affected dopamine levels. The researchers focused on the dopamine machinery in the brain's corticostriatal region, which is believed to contain the "habit" circuitry that plays a major role in the compulsive drug seeking seen in people addicted to methamphetamine and amphetamine.

Long-term exposure to methamphetamine caused a depression of the synaptic dopamine machinery in the corticostriatal region that lasted for months after the mice were no longer given the drug. However, a dose of methamphetamine reversed the depressive effects on the synaptic dopamine machinery.

The researchers also found that the drug produced its long-term effect by altering specific types of receptors for dopamine and another neurotransmitter called acetylcholine.

They concluded that the mechanism they identified "might provide a synaptic basis that underlies addiction and habit learning and their long-term maintenance."

The findings, which were published in the April 10 issue of the journal Neuron, could help lead to more effective treatments for addiction to methamphetamine and related drugs.

In a preview of the research article in the same issue of Neuron, Jeremy Day and Regina Carelli suggested that methamphetamine's effects on the brain discovered by Bamford and his colleagues might disrupt the normal machinery for learning in the brain, "leading to aberrant reward processing and action selection. If so, the discovery of methods to reverse this plasticity may be a promising avenue for addiction treatment."

More information

The U.S. National Institute on Drug Abuse has more about methamphetamine.

-- Robert Preidt

SOURCE: Cell Press, news release, April 9, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. UCLA researchers identify markers that may predict diabetes in still-healthy people
3. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
4. Bipolar disorder relapses halved by Melbourne researchers
5. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
6. High and mighty: first common height gene identified by researchers behind obesity gene finding
7. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
8. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
9. Researchers develop long-lasting growth hormone
10. Jefferson immunology researchers halt lethal rabies infection in brain
11. Purdue researchers develop technology to detect cancer by scanning surface veins
Post Your Comments:
(Date:6/27/2016)... ... June 27, 2016 , ... ... payment industry today announced its strategic partnership with Connance, a healthcare industry ... The two companies’ proven, proprietary technology combine to provide health systems, hospitals ...
(Date:6/27/2016)... ... 27, 2016 , ... recently awarded their highest five-star rating to Best ... individuals in the United States and Canada wear eyeglasses. Once considered to be a ... and make a fashion statement. Even celebrities use glasses as a way of creating ...
(Date:6/26/2016)... Michigan (PRWEB) , ... June 26, 2016 , ... On ... as sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle ... honor of the city’s history as home to some of the world’s leading providers ...
(Date:6/26/2016)... ... 2016 , ... PawPaws brand pet supplements owned by Whole Health ... the health of felines. The formula is all-natural and is made from Chinese herbs ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... they have been diagnosed with endometriosis. These women need a treatment plan to ... a comprehensive approach that can help for preservation of fertility and ultimately achieving ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 26, 2016 ... value-based care operating models within the health care industry ... greater financial efficiency , Deloitte offers a suite ... key business issues impacting efficient cost optimization: labor resource ... , These services facilitate better outcomes and better economics ...
(Date:6/24/2016)... June 24, 2016  Global Blood Therapeutics, Inc. (GBT) ... developing novel therapeutics for the treatment of grievous ... the closing of its previously announced underwritten public ... the public offering price of $18.75 per share. ... offered by GBT. GBT estimates net proceeds from ...
(Date:6/24/2016)... , June 24, 2016 ... of the "Structural Electronics 2015-2025: Applications, Technologies, ... In-Mold Electronics, Smart Skin, ... Photovoltaics Structural electronics involves electronic ... load-bearing, protective structures, replacing dumb structures such as ...
Breaking Medicine Technology: