Navigation Links
Researchers Create Long-Acting Local Anesthetic
Date:4/14/2009

Slow-release injection could ease discomfort in specific areas for days, weeks

TUESDAY, April 14 (HealthDay News) -- A new, slow-release injectable nerve block could be a long-lasting local anesthetic for the treatment of pain during and after surgery, U.S. researchers say.

The shot may also help patients with chronic pain, they add.

A team at Children's Hospital Boston created the anesthetic by packaging the potent painkiller saxitoxin into specially designed fat-based particles called liposomes. When tested in rats, this method proved effective in preventing pain and caused no damage to nerve or muscle cells.

The research was published online in this week's issue of the Proceedings of the National Academy of Sciences.

"The idea was to have a single injection that could produce a nerve block lasting days, weeks, maybe even months," study senior author Dr. Daniel Kohane, of the division of critical care medicine in the department of anesthesiology, said in a Children's Hospital Boston news release. "It would be useful for conditions like chronic pain where, rather than use narcotics, which are systemic and pose a risk of addiction, you could just put that piece of the body to sleep, so to speak."

He and his colleagues are now improving the formulation to make it last even longer, while ensuring it's safe.

"It is conceivable we could have a formulation that is suitable for clinical trials [for humans] before too long," Kohane said.

"If these long-acting, low-toxicity formulations of local anesthetics are shown to be effective in humans, they could have a major impact on the treatment of acute and chronic pain. This slow-release technology may also have broader applications in drug delivery for the treatment of a variety of diseases," said Alison Cole, of the U.S. National Institute of General Medical Science, which partially funded the research.

More information

The American Academy of Family Physicians has more about pain control after surgery.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, April 13, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ex-White House Drug Czar McCaffrey, U.S. Congress Drug Caucus Chair Cummings, CRC Health CEO Karlin Join Hopkins Researchers at News Conference April 17 on Breakthrough Study: Internet Video Drug Treatment as Effective as Traditional Counseling
2. Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimers disease
3. Pitt, Berkeley researchers reconstruct seashells to model nervous system function
4. N. California Researchers Testing Whether Marijuana Chemical Can Slow Cancer Growth, With Funding by Susan G. Komen for the Cure(R)
5. Researchers find promotion is bad for mental health and stops your visiting the doctor
6. Mayo researchers discover mechanism of cell type-specific signaling in tumor development
7. Researchers Profile the Light Smoker
8. Alarming Rise in Autism Brings Hundreds of Parents, Researchers and Clinicians Together from Around the World to Atlanta April 17-19, 2009
9. PhRMA Honors Gardasil(r) Researchers With Discoverers Award
10. Researchers identify personality traits
11. Young eye researchers receive prestigious ARVO-AFER/Merck award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Create Long-Acting Local Anesthetic
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids ... sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited ... all ages; it is a non-competitive, non-timed event, which is all about having fun ...
(Date:10/13/2017)... ... 13, 2017 , ... “The Journey: From the Mountains to the Mission Field”: ... souls in the Philippines. “The Journey: From the Mountains to the Mission Field” is ... Bible. She has taught all ages and currently teaches a class of ladies at ...
(Date:10/12/2017)... , ... October 12, 2017 , ... Planet Fitness, one ... U.S., announced today its plans to open a flagship location in Covington, LA at ... former Rooms To Go store next to Office Depot in the Holiday Square shopping ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... leader in post-acute health care, have expanded their existing home health joint venture ... , AccentCare has been operating a joint venture home health company with Asante, ...
(Date:10/12/2017)... ... ... Leading pediatric oncology experts at Children’s National Health System will ... the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by Jeffrey ... Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the Division ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an update ... Puerto Rico , where the company manufactures ... Following a comprehensive onsite assessment, the ... temporary loss of power and minimal water damage due ... have resumed, and the company expects to return to ...
(Date:10/10/2017)... EXTON, Pa. , Oct. 10, 2017   ... leader in innovative solutions for injectable drug administration, today ... of West,s ID Adapter for improving the intradermal administration ... the Fourth Skin Vaccination Summit in May 2017 by ... Team Lead, Polio Department, World Health Organization (WHO), and ...
(Date:10/5/2017)...  In response to the nationwide opioid epidemic, ... (AAOMS) released prescribing recommendations that urge ibuprofen – ... a first-line therapy to manage a patient,s acute ... Recognizing the value and importance of the ... Acute and Postoperative Pain Management" stresses that practitioners ...
Breaking Medicine Technology: