Navigation Links
Researchers Create Long-Acting Local Anesthetic
Date:4/14/2009

Slow-release injection could ease discomfort in specific areas for days, weeks

TUESDAY, April 14 (HealthDay News) -- A new, slow-release injectable nerve block could be a long-lasting local anesthetic for the treatment of pain during and after surgery, U.S. researchers say.

The shot may also help patients with chronic pain, they add.

A team at Children's Hospital Boston created the anesthetic by packaging the potent painkiller saxitoxin into specially designed fat-based particles called liposomes. When tested in rats, this method proved effective in preventing pain and caused no damage to nerve or muscle cells.

The research was published online in this week's issue of the Proceedings of the National Academy of Sciences.

"The idea was to have a single injection that could produce a nerve block lasting days, weeks, maybe even months," study senior author Dr. Daniel Kohane, of the division of critical care medicine in the department of anesthesiology, said in a Children's Hospital Boston news release. "It would be useful for conditions like chronic pain where, rather than use narcotics, which are systemic and pose a risk of addiction, you could just put that piece of the body to sleep, so to speak."

He and his colleagues are now improving the formulation to make it last even longer, while ensuring it's safe.

"It is conceivable we could have a formulation that is suitable for clinical trials [for humans] before too long," Kohane said.

"If these long-acting, low-toxicity formulations of local anesthetics are shown to be effective in humans, they could have a major impact on the treatment of acute and chronic pain. This slow-release technology may also have broader applications in drug delivery for the treatment of a variety of diseases," said Alison Cole, of the U.S. National Institute of General Medical Science, which partially funded the research.

More information

The American Academy of Family Physicians has more about pain control after surgery.



-- Robert Preidt



SOURCE: Children's Hospital Boston, news release, April 13, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ex-White House Drug Czar McCaffrey, U.S. Congress Drug Caucus Chair Cummings, CRC Health CEO Karlin Join Hopkins Researchers at News Conference April 17 on Breakthrough Study: Internet Video Drug Treatment as Effective as Traditional Counseling
2. Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimers disease
3. Pitt, Berkeley researchers reconstruct seashells to model nervous system function
4. N. California Researchers Testing Whether Marijuana Chemical Can Slow Cancer Growth, With Funding by Susan G. Komen for the Cure(R)
5. Researchers find promotion is bad for mental health and stops your visiting the doctor
6. Mayo researchers discover mechanism of cell type-specific signaling in tumor development
7. Researchers Profile the Light Smoker
8. Alarming Rise in Autism Brings Hundreds of Parents, Researchers and Clinicians Together from Around the World to Atlanta April 17-19, 2009
9. PhRMA Honors Gardasil(r) Researchers With Discoverers Award
10. Researchers identify personality traits
11. Young eye researchers receive prestigious ARVO-AFER/Merck award
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Researchers Create Long-Acting Local Anesthetic
(Date:10/12/2017)... WILMINGTON, Del. (PRWEB) , ... October 12, 2017 ... ... technology and advisory services for healthcare compliance program management, will showcase a range ... and National Association for Assisted Living (NCAL) Convention and Expo to be held ...
(Date:10/12/2017)... CITY, Fla. (PRWEB) , ... October 12, 2017 , ... ... cold therapy products, announced today the introduction of an innovative new design of the ... multipurpose pad so you get maximum comfort while controlling your pain while using cold ...
(Date:10/12/2017)... ... October 12, 2017 , ... Dr. Parsa Mohebi, the Los ... article to the newly revamped Cosmetic Town journal section, featuring articles ... procedure known as Follicular Unit Extraction (FUE). , Dr. Mohebi says ...
(Date:10/12/2017)... RAPIDS, Mich. (PRWEB) , ... October 12, 2017 ... ... Wellness, has been named one of Michigan’s 2017 Best and Brightest in Wellness® ... and Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Dining at the University of California Berkeley, and other leading institutions in announcing ... buying power of institutions to change the way animals are raised for food. ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... , Oct. 2, 2017 The Rebound mobile ... the struggle to reverse the tide of prescription drug addiction. ... regulating their medicine intake and stepping down their dosage in ... to launch in December 2017; the first 100,000 people to ... more at http://www.rebound-solution.com/ ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium , ... File solutions, today—from the IQPC Trial Master Files ... , NL)—announced that EastHORN Clinical Services has selected ... programs and TMF management. EastHORN, a leading European ... platform to increase transparency to enable greater collaboration ...
(Date:9/19/2017)... Sept. 19, 2017 HistoSonics, Inc., a venture-backed medical device company developing a non-invasive, ... tissues, announced three leadership team developments today:   ... ... ... Veteran medical device executive Josh Stopek , PhD, ...
Breaking Medicine Technology: