Navigation Links
Researchers Create Long-Acting Local Anesthetic

Slow-release injection could ease discomfort in specific areas for days, weeks

TUESDAY, April 14 (HealthDay News) -- A new, slow-release injectable nerve block could be a long-lasting local anesthetic for the treatment of pain during and after surgery, U.S. researchers say.

The shot may also help patients with chronic pain, they add.

A team at Children's Hospital Boston created the anesthetic by packaging the potent painkiller saxitoxin into specially designed fat-based particles called liposomes. When tested in rats, this method proved effective in preventing pain and caused no damage to nerve or muscle cells.

The research was published online in this week's issue of the Proceedings of the National Academy of Sciences.

"The idea was to have a single injection that could produce a nerve block lasting days, weeks, maybe even months," study senior author Dr. Daniel Kohane, of the division of critical care medicine in the department of anesthesiology, said in a Children's Hospital Boston news release. "It would be useful for conditions like chronic pain where, rather than use narcotics, which are systemic and pose a risk of addiction, you could just put that piece of the body to sleep, so to speak."

He and his colleagues are now improving the formulation to make it last even longer, while ensuring it's safe.

"It is conceivable we could have a formulation that is suitable for clinical trials [for humans] before too long," Kohane said.

"If these long-acting, low-toxicity formulations of local anesthetics are shown to be effective in humans, they could have a major impact on the treatment of acute and chronic pain. This slow-release technology may also have broader applications in drug delivery for the treatment of a variety of diseases," said Alison Cole, of the U.S. National Institute of General Medical Science, which partially funded the research.

More information

The American Academy of Family Physicians has more about pain control after surgery.

-- Robert Preidt

SOURCE: Children's Hospital Boston, news release, April 13, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Ex-White House Drug Czar McCaffrey, U.S. Congress Drug Caucus Chair Cummings, CRC Health CEO Karlin Join Hopkins Researchers at News Conference April 17 on Breakthrough Study: Internet Video Drug Treatment as Effective as Traditional Counseling
2. Mount Sinai researchers discover novel mechanisms that might causally link type-2 diabetes to Alzheimers disease
3. Pitt, Berkeley researchers reconstruct seashells to model nervous system function
4. N. California Researchers Testing Whether Marijuana Chemical Can Slow Cancer Growth, With Funding by Susan G. Komen for the Cure(R)
5. Researchers find promotion is bad for mental health and stops your visiting the doctor
6. Mayo researchers discover mechanism of cell type-specific signaling in tumor development
7. Researchers Profile the Light Smoker
8. Alarming Rise in Autism Brings Hundreds of Parents, Researchers and Clinicians Together from Around the World to Atlanta April 17-19, 2009
9. PhRMA Honors Gardasil(r) Researchers With Discoverers Award
10. Researchers identify personality traits
11. Young eye researchers receive prestigious ARVO-AFER/Merck award
Post Your Comments:
Related Image:
Researchers Create Long-Acting Local Anesthetic
(Date:11/30/2015)... ... November 30, 2015 , ... HemoTreat™ has announced that the ... ointment to its website. , “Our goal is simple:” says Michael Blasco, HemoTreat’s ... the comparison chart and ingredient list allows our customers to quickly see why, ...
(Date:11/30/2015)... ... November 30, 2015 , ... ... by athletic teams looking to maximize recovery through quality sleep. Tim DiFrancesco, training ... consistently get a better night’s sleep. ChiliPad precisely regulates the surface temperature of ...
(Date:11/30/2015)... Plains, NJ (PRWEB) , ... November 30, 2015 ... ... their top choice for innovative, patient centered orthopedic care. Led by John ... of your injury or chronic condition, the team at Advocare Orthopedic & Sports ...
(Date:11/30/2015)... ... 30, 2015 , ... Dr. Seth D. Margulies specializes in orthodontics and is ... Margulies to experience the best available orthodontic experience in the area. Dr. Margulies ... , Orthodontics is the branch of dentistry that specializes in the diagnosis, prevention, and ...
(Date:11/30/2015)... , ... November 30, 2015 , ... Newly reviewed and ... His grandfather graduated from Tufts School of Dental Medicine in 1935. His father ... the Isola family being in dentistry as well as their commitment and passion to ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... KONG, Nov. 30, 2015 (HK$,000)For the Six Months Ended 30 September 2015 ... Income , 421,979 , 384,242 , ... , 34,719 , (18.3) Medical Insurance ... , 16.1 Medical Devices and Accessories Sales , ... Chinese Herbal Medicines Sales , 2,822 , ...
(Date:11/30/2015)... Calif. , Nov. 30, 2015 /PRNewswire/ ... the norm in U.S. medical imaging is ... increasingly popular accountable care payer-provider contracts are ... and, in their wake, alter provider-vendor relationships. ... payments will push forward new purchasing frameworks ...
(Date:11/30/2015)... Nov. 30, 2015 Oramed Pharmaceuticals Inc. (NASDAQ: ... the development of oral drug delivery systems, announced today ... at up to $50,000,000 with Hefei Tianhui Incubator of Technologies Co., Ltd. ... capsule, ORMD-0801, in China , ... . The agreements were signed at the Israel ...
Breaking Medicine Technology: