Navigation Links
Researcher wins $1.2 million grant for gene regulation work
Date:1/9/2009

TALLAHASSEE, Fla. -- A unique discovery in a Florida State University College of Medicine laboratory is the basis for research with the potential to one day help scientists learn how to stop cancer and other diseases in the tissue where they are forming.

Jamila Horabin, associate professor of biomedical sciences at the College of Medicine, has received a four-year, $1.2 million grant from the National Institutes of Health to pursue her work. Horabin recently discovered a direct link between RNA silencing and the genetic master switch controlling the sex determination process in fruit flies.

With that knowledge, she is now seeking to fully understand how a cellular process in gene regulation called the RNA-induced silencing complex (RISC) might interfere with or silence the genes assumed to be at work in nearly all forms of disease and cancer. With a greater understanding of the process, her hope is that scientists will one day be able to switch off the gene activity causing cancerous tumors and cardiovascular disease.

"We want to know how RNA silencing affects fundamental gene expression," Horabin said. "Many genes are regulated by this process, and it will have far-reaching impact if we understand how it works, which is really the hope and dream of a basic scientist."

Myra Hurt, associate dean for research and graduate programs at the College of Medicine, said Horabin's work has great potential for finding a new way of fighting disease.

"There are a number of genes involved with tumor development and metastasis, for example," Hurt said. "Imagine if you could target those genes and silence them in the tissue where they are. Here is one more layer of gene regulation that we really didn't know about until fairly recently, and now if we can understand it maybe we can use this technology to target genes involved in disease conditions very specifically and silence them."

The fruit fly offers numerous advantages for such research. Its genome has been fully mapped, so every gene is known and can be studied for cause and effect relationships in the laboratory. Additionally, the fruit fly reaches full maturity in a matter of days, is plentiful, inexpensive and, most importantly, shares remarkable similarities to humans at the level where gene activity is regulated.

"Sometimes you find that the fly gene that you are working with is similar to a human gene that is involved in directing a disease," Horabin said. "So if the fly gene is being regulated in a particular way, then odds are the human gene is being regulated the very same way."


'/>"/>

Contact: Doug Carlson
doug.carlson@med.fsu.edu
850-645-1255
Florida State University
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. Bipolar disorder relapses halved by Melbourne researchers
6. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
9. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
10. Researchers develop long-lasting growth hormone
11. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... 2016 , ... World Patent Marketing , a vertically ... automotive invention that improves the storage features of a pick up truck. , ... Cooper, CEO and Creative Director of World Patent Marketing. "Over the next five ...
(Date:4/29/2016)... Sedona, Arizona (PRWEB) , ... April 29, 2016 ... ... Shamanic Healing and Spiritual Awakening , announces the addition Onnit brand Alpha BRAIN ... , The addition of Onnit brain and mood optimization products to the store ...
(Date:4/29/2016)... ... April 29, 2016 , ... The White House announced efforts ... more information about their loan terms and accounts, and more protections for borrowers. ... federal and private loans, has reached $1.3 trillion, with 43 million Americans holding ...
(Date:4/29/2016)... ... April 29, 2016 , ... The Wharton School of ... Grand Prize of the 2016 Wharton Business Plan Competition —as well as ... Award, and the Committee Award for Most ‘Wow Factor,’ making them the first ...
(Date:4/29/2016)... Torrance, CA (PRWEB) , ... April 29, 2016 , ... ... comprehensive cosmetic dental treatments to improve smiles. Cosmetic dentistry is a fast-growing field as ... smiles. This offer allows patients to learn more about the options currently available to ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016 TapImmune,Inc. (TPIV), a ... and gene-based immunotherapeutics and vaccines for the treatment of cancer ... the 3rd Annual Growth Capital Expo to be ... at Caesars Palace in Las Vegas, Nevada.  The Company ... 4 th by Dr. John N. Bonfiglio ...
(Date:4/27/2016)... April 27, 2016   ... Growth in Recurring Consumable Sales  Clinical sales ... Kea Technologies (Euronext: MKEA, OTCQX: MKEAY) inventor of Cellvizio®, ... sales for the first quarter ended March 31, 2016 ... execution of its commercial strategy. First Quarter ...
(Date:4/27/2016)... 27, 2016  Bayer Animal Health today announced ... the University of Florida College of Veterinary Medicine, ... in Communication Award (BECA). Brittany was selected from ... a total of $70,000 in scholarship funds through ... Bayer has provided a total of $232,500 in ...
Breaking Medicine Technology: