Navigation Links
Researcher to provide new insight for treating vascular disease
Date:10/27/2008

COLUMBIA, Mo. The blood circulates through the body in an intricate process that researchers are only beginning to understand. Now, University of Missouri researcher Steven Segal has received the National Heart, Lung and Blood Institute's prestigious Method to Extend Research in Time (MERIT) Award for his work in defining the signaling processes that control blood flow in the smallest, microscopic blood vessels, the microcirculation. Understanding these events could help researchers find novel approaches to fighting vascular disease associated with hypertension and diabetes and help to combat the adverse effects of aging on physical performance.

"Blood vessels are composed of individual cells arranged to form tubes that direct blood flow in tissues and organs. Within the microcirculation, the control of blood flow requires vascular cells to synchronize their activity in order for blood vessels to constrict and reduce blood flow or to dilate and increase blood flow," said Segal, professor in the Department of Medical Pharmacology and Physiology in the School of Medicine and Investigator in the Dalton Cardiovascular Research Center. "The goal of my research is to determine how cells of the microcirculation actually coordinate their activity to control vessel diameter in order to regulate blood flow. Gaining new insight into these processes will facilitate the development of new strategies for treating vascular diseases and promoting an active lifestyle."

The microvessels that control blood flow are constantly dilating and constricting as they regulate their diameter according to the metabolic needs of the tissues they supply. As illustrated in the accompanying figure, these vessels are lined by a continuous layer of endothelial cells which, in turn, are surrounded by smooth muscle cells that can relax (causing "vasodilation") or contract (causing "vasoconstriction").

In response to physical activity, smooth muscle and endothelial cells in the microcirculation of skeletal muscles are stimulated to produce electrical and chemical signals. These signals are essential for coordinating the activity of entire branches and networks of the microcirculation. These networks act as a team that orchestrates the delivery of oxygen and nutrients as well as removes metabolic products in active tissues.

"The research in my laboratory is concerned with understanding the cellular and molecular events that initiate the signals involved in controlling blood flow, how such signals are transmitted from cell to cell to orchestrate vasodilation and vasoconstriction in an organized manner, and how these integrative processes are governed by the nervous system," said Segal, who joined the faculty at MU in 2006. "In turn, understanding these basic processes that are integral to the microcirculation provides new insight for developing novel approaches to treating vascular disease. The research environment at Mizzou is ideal for pursuing these goals."

The MERIT Award is designed to provide long-term, stable support to investigators whose research competence, productivity and scientific contributions are distinctly superior and who are likely to continue to perform in an outstanding manner.


'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related medicine news :

1. Researchers Find More Genes Linked to Lung Cancer
2. Researchers estimate lives lost due to delay in antiretroviral drug use for HIV/AIDS in South Africa
3. Georgetown University Med Center reproductive health researchers tackle public health concerns
4. Stem-cell sentry sounds the alarm to maintain balance between cancer and aging, U-M researchers find
5. Steroids aid recovery from pneumonia, UT Southwestern researchers say
6. Researchers Create Embryonic-Like Stem Cells From Human Testes
7. UT researchers to study massive transfusion at major trauma centers
8. Duke researchers show reading can help obese kids lose weight
9. Researchers use nanoparticles to deliver treatment for brain, spinal cord injuries
10. The Leukemia & Lymphoma Society Awards Major Grant to Stanford Researcher
11. Researchers create first model for retina receptors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... ... ... People across the U.S. are sharpening their pencils and honing their writing ... which patients and their families pay tribute to a genetic counselor by nominating him ... Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. , In April, Genome ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative Solutions today ... cultivation and processing operations at its production facility, and opened its first two ... the manufacturer of a complete system of proactive air and surface purification solutions ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016 Any dentist ... many challenges of the current process. Many of them do ... of the technical difficulties and high laboratory costs involved. And ... to offer it at such a high cost that the ... it. Dr. Parsa Zadeh , founder of ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
(Date:6/23/2016)... June 23, 2016 , , ... July 7, 2016 , , , , LOCATION: , , ... , , , EXPERT PANELISTS:  , , , Frost & ... Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, ... The global pharmaceutical industry is witnessing an exceptional era. Several new ...
Breaking Medicine Technology: