Navigation Links
Researcher refining synthetic molecules to prevent HIV resistance
Date:12/16/2008

COLUMBIA, Mo. Evolving HIV viral strains and the adverse side effects associated with long-term exposure to current treatments propel scientists to continue exploring alternative HIV treatments. In a new study, a University of Missouri researcher has identified broad-spectrum aptamers. Aptamers are synthetic molecules that prevent the HIV virus from reproducing. In lab tests, aptamers known as RT5, RT6, RT47 and some variants of those were recently identified to be broad-spectrum, which would allow them to treat many subtypes of HIV-1. Now, researchers are gaining a better understanding of the biochemical characteristics that make aptamers broad-spectrum.

"Aptamers are promising candidates as anti-HIV and anti-cancer therapeutic agents for reducing virus infectivity," said Donald Burke-Aguero, an associate professor in the Department of Molecular Microbiology and Immunology in the Christopher S. Bond Life Sciences Center. "They also might be beneficial in developing gene therapy applications."

In cell cultures, aptamers have suppressed viral replication by inhibiting important enzymes in the HIV-1 virus. One important enzyme is reverse transciptase (RT), which copies genetic material and generates new viruses. Scientists hope to create aptamers that will disrupt RT and suppress the virus's growth. Aptamers can reduce viral infectivity by blocking the normal action of RT.

"Successful aptamers get in the way of the virus's genetic material, which it is trying to copy as it invades a cell," Burke-Aguero said. "The structure of the aptamer is very important. Broad-spectrum aptamers must have an adaptable structure, which make it difficult for RT to get around them.

There are several different HIV-1 subtypes around the world, and each subtype has a different amino acid sequence making it difficult to create a single aptamer that will work on every substype. Synthetic molecules must be the right size and shape to bind with
'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Indiana University researchers revisit male bisexuality
2. Breast cancer risk varies in young women with benign breast disease, Mayo Clinic researchers say
3. Mayo researchers find potential links between breast density and breast cancer risk
4. Mayo Clinic researchers find tamoxifens power comes from endoxifen
5. Researcher Receives Free Flow Cytometer System as First Winner of Accuri(R) Flow Cytometer Creativity Awards Program
6. Researcher Receives Free C6 Flow Cytometer(R) System as First Winner of Accuri Flow Cytometer(R) Creativity Awards Program
7. UBC researchers discover gene mutation that causes eye cancer
8. Researchers report on convergence of technology
9. Einstein researchers discover protein that contributes to cancer spread
10. Researchers & Department of Defense Question Multiple Vaccine Administration
11. Researchers gain new insight on wonder of cell division
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... Horizon Blue ... the 50 Best Companies for Latinas in the LATINA Style 50 Report that recognizes ... , For 2015, Horizon BCBSNJ climbs from number 24 to 21 ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... and collaboration, announces Splashtop Business for Remote Support , a solution optimized ... solution. Unhappy with the escalating renewal prices and inadequate customer services of ...
(Date:9/1/2015)... ... September 01, 2015 , ... The ... Information Management has been granted continued accreditation based on a successfully completed ... “Achieving and maintaining this accreditation takes the involvement and dedication of each ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... ... announced the release of version 5.2 of the FirstSpirit Content Management System with ... initiative. With the new version of FirstSpirit, companies will be well on their ...
(Date:9/1/2015)... ... , ... Two of Washington D.C.’s most respected chefs are using their global ... Recently named “the next big thing” in the culinary world by Elle Spain, award-winning ... behind food and reclaiming culinary traditions on the brink of extinction. According to Amy ...
Breaking Medicine News(10 mins):Health News:Horizon Blue Cross Blue Shield of New Jersey Named One of the 50 Best Companies for Latinas by Latina Style Magazine 2Health News:Horizon Blue Cross Blue Shield of New Jersey Named One of the 50 Best Companies for Latinas by Latina Style Magazine 3Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 2Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 3Health News:Splashtop Launches Splashtop Business for Remote Support, the Simple, Reliable, and Cost-Effective Solution for MSPs and IT Professionals 4Health News:Edge Information Management Granted Continued NAPBS Accreditation 2Health News:Edge Information Management Granted Continued NAPBS Accreditation 3Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 3Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 2Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 3Health News:Chefs Amy Riolo and Luigi Diotaiuti Embark on Culinary Diplomatic Quest to Build Bridges through Global Cuisine 4
... The San Diego Supercomputer Center (SDSC) at the University ... (Leadership in Energy & Environmental Design) Gold certification for ... certification was granted in the ,Existing Buildings Operations & ... a non-profit organization promoting efficient and energy-saving ,green, buildings. ...
... -- Weight loss and malnutrition are among the medical ... hospital stays for older adults with hip fractures, a ... occur each year in the United States, often resulting ... disability, and admission to a nursing home. This ...
... skinned knees on the playground and coaxing their children ... their offspring,s physical health in middle age. In ... Science , Brandeis psychologist Margie Lachman with Gregory Miller ... the University of California, Los Angeles reveal that while ...
... preventing colon cancer be as simple as developing a taste ... study, scientists showed that human colon cancer cells die when ... present in one cup of this brew, which has long ... "The caffeine derivatives in mate tea not only induced death ...
... Jan. 23, 2012 The March of Dimes, along with ... birth prevention an opportunity to learn from each other and ... under 10 percent and give more babies a healthy start. ... speaker for the Prematurity Prevention Symposium. The symposium will was ...
... maps has revealed in unprecedented detail the current global pattern ... changed over a number of years. In a study ... of researchers from the Malaria Atlas Project (MAP), funded mainly ... effort to assemble all available data worldwide on the risk ...
Cached Medicine News:Health News:SDSC's East Building receives LEED Gold Certification 2Health News:Hip Fracture Patients Often Have Other Health Problems 2Health News:Nurturing mothers rear physically healthier adults 2Health News:Nurturing mothers rear physically healthier adults 3Health News:Compounds in mate tea induce death in colon cancer cells 2Health News:March of Dimes launches Prematurity Prevention Network 2Health News:March of Dimes launches Prematurity Prevention Network 3Health News:New malaria maps to guide battle against the disease 2
(Date:9/1/2015)... NOWDiagnostics Inc., based in Springdale, Ark. ... Canada , a move that brings the ... people have greater access to information concerning their health. ... unique blood-based rapid tests that allow health care providers ... of ailments and diseases. ZBx Corporation, a ...
(Date:9/1/2015)... Sept. 1, 2015 Emerus Holdings, a ... emergent, inpatient and diagnostic care in partnership with ... a definitive agreement to receive a strategic investment ... a leading health care investment firm. ... patient-centric acute episodic and ambulatory clinical services to ...
(Date:9/1/2015)... , Sept. 1, 2015 Sleep ... sleep therapy, and HGE Health Care Solutions, a ... announced today a comprehensive sleep management and cost ... (OSA). OSA is a chronic medical ... sleep and may increase a patient,s risk for ...
Breaking Medicine Technology:NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 2NOWDiagnostics Inc. Acquires Canada's ZBx Corporation 3Emerus Announces Significant Strategic Investment By Welsh, Carson, Anderson & Stowe 2Emerus Announces Significant Strategic Investment By Welsh, Carson, Anderson & Stowe 3Sleep Specialists, LLC and HGE Health Care Solutions Announce Comprehensive Sleep Program 2
... 2012 /PRNewswire-Asia/ -- As the whole world battles against cancer, ... a great improvement. Cancer is still the number one cause ... patients have, in recent times, managed to survive for more ... are available in Korea. The Korean government recently ...
... TeDan Surgical Innovations , industry leader in surgical ... Series MIS Anterior Hip Retractor System . TeDan Surgical,s ... arms with attachable retractors, enabling surgeons to perform the ... assistant. Dr. Lawrence Menendez and Dr. ...
Cached Medicine Technology:Survival Rate of Cancer Patients in Korea Ranked in the Top in the World 2New Minimally Invasive Hip Retractor Revolutionizes Anterior Hip Replacement Procedures 2
Ergotec Vetriretinal Instrument System. 2 mm pointed tips with 0.6 mm platform. 20 gauge shaft tapers to 23 gauge....
Angled shafts with 12 mm scaled jaws. 1 mm teeth on one jaw fit into holes on the other jaw. Slide lock and serrated handle with polished finish. Left. Most popular size or model....
Angled shafts with 9 mm scaled jaws. 1 mm teeth on one jaw fit into holes on the other jaw. Slide lock and serrated handle with polished finish. Left....
Angled 13.5 mm adjustable blades. Teeth in lower jaws fit into holes in upper jaws. Grooves in lower jaw for passage of suture needles. Round knurled handle with polished finish....
Medicine Products: