Navigation Links
Researcher of the University of Navarra discovered potential antidepressant compounds
Date:2/20/2008

This release is also available in Spanish.

Luis Berrade, a researcher with the Drug R&D Unit of the University of Navarra, has discovered new compounds with the potential for anti-depressant activity. All told, the chemist of the School of Sciences synthesized 51 compounds whose biological characteristics were evaluated by two of the most prestigious groups in this area: the Mediterranean Institute of Neurobiology, located in Italy, and the Department of Pharmacology of the University of Oslo.

The results obtained formed part of his doctoral dissertation, entitled Design, synthesis and preliminary biological evaluation of new derivatives of benzo[b]-thiophene in the Search for Agents for a New Anti-Depressant Therapy.

As the researcher explained, the new molecules which he designed affect two brain targets which are considered to be keys in the development of processes of depression. One of these is the serotonin transporter, whose reuptake reduction has already been shown to improve mood; the other is the serotoninergic receptor 5-HT7, a therapeutic target for serotonin whose modulation can provoke anti-depressant effects.

Trials in vivo

In order to study these two key targets, Luis Berrade developed chemical structures via the fusion of two similar chemical compounds: the benzo[b]-thiophene ring and arilamine. Following this, he compared the new compounds with a drug currently on the market, Fluoxetine. As a result of this research, he explained, we discovered that nine of these compounds demonstrated greater affinity, in this sense, than the commercial drug. As a consequence of this discovery, in January in vivo trials were begun in order to test their anti-depressant activity in mice.

This study, one of the first in the world in this specialty, was undertaken in collaboration with the Department of Pharma
'/>"/>

Contact: Oihane Lakar
oihane@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

0

GOOD

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. Bipolar disorder relapses halved by Melbourne researchers
6. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
7. High and mighty: first common height gene identified by researchers behind obesity gene finding
8. Researchers estimate about 9 percent of US children age 8 to 15 meet criteria for having ADHD
9. Majority of 2.4 Million U.S. Children With ADHD Not Diagnosed or Consistently Treated, According to New Gold Standard Study by Cincinnati Childrens Researchers
10. Researchers develop long-lasting growth hormone
11. UVa researcher awarded $3.6 million grant to fight drug-resistant bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2013)... 22, 2013 CoCENTRIX, a leading ... Health and Human Services and community providers, announced ... (ADMH) selected the CoCENTRIX Coordinated Care Platform ... the Health Records and coordinate care within and ... , CoCENTRIX is transitioning the hospitals' official records ...
(Date:5/22/2013)... 22, 2013 LDM Global ( http://www.ldmglobal.com ... services for law firms, corporations and government agencies announces ... cloud-based e-discovery software company, to deliver defensible ESI collections ... partnership, Cumulus Data and LDM Global hosted a VIP ... Tuesday, May 21st. This event was in conjunction ...
(Date:5/22/2013)... May 22, 2013 BroadConnect Telecom, ... and IT security solutions in North America announced ... of its newest BroadConnect hosted security solutions. Available ... hybrid combination, BroadConnect’s new Security as a Service ... the Internet connection of their choice, while optimizing ...
(Date:5/22/2013)... Poor adherence to appropriate medication therapy has ... and death (some 125,000 deaths in the U.S. every ... costs. It’s been estimated that between 33% and 69% ... medication adherence — a reality that costs the American ... dire is the degree of medication non-adherence — and ...
(Date:5/22/2013)... (PRWEB) May 22, 2013 Mari’s Skin Care, ... has become the first in the state of Texas to ... Meta Therapy- Medical and Esthetic Tissue Activation, also known as ... over four years in Europe, but has just recently made ... improves the skin from inside out by building collagen and ...
Breaking Medicine News(10 mins):Health News:The State of Alabama Selects the CoCENTRIX Coordinated Care Platform to Facilitate Care for Its Citizens Treated in State Psychiatric Hospitals 2Health News:The State of Alabama Selects the CoCENTRIX Coordinated Care Platform to Facilitate Care for Its Citizens Treated in State Psychiatric Hospitals 3Health News:LDM Global Enhances Forensic Data Collection Services with eCloudCollect 2Health News:LDM Global Enhances Forensic Data Collection Services with eCloudCollect 3Health News:BroadConnect Telecom to Launch Enterprise-Grade Hosted Security Solutions Engineered to Meet the Demands of Real World Business 2Health News:Patient Prompt® Announces New Drug Adherence Program to Assist in Prescribed Medication Compliance 2Health News:Mari's to Offer New Treatment from Europe 2
... to a new report by the UNH scientist, the beginning ... The effect, which is a result of global warming, has ... a ripple effect in all the happenings takes place in ... March 20th marking the vernal equinox and the official start ...
... a simple and natural remedy for reducing the intensity ... // by just eating more fruits and vegetables. They ... antioxidants, are capable of accelerating and worsening an attack. ... to a diet low in antioxidants and their asthma ...
... of seagrass beds around the world has resulted ... and sediment stabilizers affecting the shallow-water ecosystems // ... resources and marine science, University of New Hampshire. ... deeply affected even the commercially valuable valuable shellfish ...
... have discovered how to measure the absorption of multi-walled ... nanotubes were discovered in 1991, and have a great ... storage in fuel cells. But despite their promise, a ... carbon nanotubes will impact the living environment. This discovery ...
... release on the 28th regarding a study on stethoscope accuracy ... that physicians with more experience // are better able to ... heart disease. The researchers felt that with a greater experience ... pathologic heart disorders., ,Publishing their findings in the March ...
... The New York State Department of Health has confirmed coliform ... by North Country Spring Water//, Ltd. For this reason ... recalling all of its bottled water products. Coliform bacteria ... presence of coliform bacteria in bottled water is a violation ...
Cached Medicine News:Health News:‘Natural Spring’ Starts A Week Ahead Now Than Before: UNH Scienti 2Health News:‘Natural Spring’ Starts A Week Ahead Now Than Before: UNH Scienti 3Health News:Global Seagrass Decline Affects Shallow-water Ecosystems 2Health News:Global Seagrass Decline Affects Shallow-water Ecosystems 3Health News:Absorption Of Carbon Nanotube Measured In Worms Revolutionize Cancer Research 2Health News:Experienced Physicians Diagnose Heart Disease’s Earlie 2
(Date:5/22/2013)... N.Y. , May 22, 2013  MGT Capital ... Company will present at the Second Annual Marcum LLP ... New York City at the Grand ... and Chief Executive Officer, will update investors and answer ... The Company,s presentation is scheduled to begin at ...
(Date:5/22/2013)... MAPLE GROVE, Minn. , May 22, ... today announced the successful completion of its ... (extended-release topiramate), an internally developed program for ... the company,s proprietary formulation technology.  USL255 is ... and reduce fluctuations in topiramate blood levels ...
(Date:5/22/2013)... , May 22, 2013 Hemoglobin A1C ... patients with Type 2 diabetes, while modest improvements ... health outcomes and can lead to substantial healthcare ... the International Society for Pharmacoeconomics and Outcomes Research ... two studies, sponsored by Valeritas, makers of the ...
Breaking Medicine Technology:MGT Capital Investments, Inc. To Present At The Second Annual Marcum LLP MicroCap Conference 2MGT Capital Investments, Inc. To Present At The Second Annual Marcum LLP MicroCap Conference 3MGT Capital Investments, Inc. To Present At The Second Annual Marcum LLP MicroCap Conference 4Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 2Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 3Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 4Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 2Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 3Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 4Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 5Type 2 Diabetes Control Worsening, According To Study Of Patients On Commercial Insurance 6
... designed for more uniform drug ... ... Boston,Scientific Corporation (NYSE: BSX ) today announced comprehensive data ... historically controlled trials, which evaluate,the TAXUS(R) Liberte(R) Paclitaxel-Eluting Stent System in ...
... with Kogenate FS Reduces the,Risk of Joint Damage ... Damage, BERKELEY, Calif., Oct. 10 Bayer ... Drug Administration (FDA) has,approved routine prophylaxis with Kogenate(R) ... bleeding episodes and the risk of,joint damage in ...
Cached Medicine Technology:Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent 2Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent 3Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent 4Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent 5Taxus Atlas Studies Reinforce Safety and Efficacy of Boston Scientific's Next-Generation Taxus Liberte Stent 6FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 2FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 3FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 4FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A 5
Full Handle Laseredge Implant Blade Knife, 4.0 mm straight. Blade dimension: 15.2 mm x 4.0 mm x 3.0 mm x 1.6 mm....
Full Handle Laseredge Crescent Blade Knife, straight. Blade tip dimension: 12.7 mm x 2.0 mm x 3.8 mm....
Full Handle Laseredge Stab Blade Knife, 45 blade. Blade tip dimension: 8.9 mm x 1.9 mm x 1.9 mm....
Full Handle Laseredge Stab Blade Knife, 15 blade. Blade tip dimension: 11.1 mm x 1.5 mm x 5.7 mm....
Medicine Products: