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Research warns that human papillomavirus might cause bladder cancer
Date:9/25/2007

observational case studies published up to July 2005, in order to establish the degree of relationship found between bladder cancer and HPV infection.

Standardization of methods

The study carried out at the UGR points out that the relationship between these two diseases depends on the method used: these scientists found different results depending on whether the research was based on the persons DNA or not. Of the 44 studies reviewed, in 39 the presence of DNA was studied. In the other 7 studies the HPV infection was studied through antigen or antibody detection".

The great majority of these studies use PCR (Polymerase Chain Reaction) for the analysis. With this technique it is possible to duplicate as many times as desired a fragment of DNA in a test tube, and millions of identical molecules can be created from a single DNA molecule.

The relationship between HPV and bladder cancer might be due to the fact that the microorganism which generates the infection has DNA. Therefore, it acts directly on the cell nucleus and makes the cell cancerous. Moreover, the infection spreads quickly when healthy mucus comes into contact with infected mucus.

The research performed by the UGR points out that there might be a relationship between Human Papillomavirus infection and the appearance of the tumor. However, Gutirrez Fernndez warns that in order to draw a final conclusion, it is necessary to carry out a study with a sufficient number of cases and samples in which a combination of several microbiological techniques is applied to the same subject and sample.


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Contact: Jos Gutirrez Fernndez
josegf@ugr.es
34-958-246-119
Universidad de Granada
Source:Eurekalert

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