Navigation Links
Research update: Chemists find help from nature in fighting cancer
Date:2/27/2013

lso have anti-cancer activity. For the new study, they created even more compounds by systematically varying the natural structures adding or removing certain chemical groups from different locations.

The researchers tested 60 compounds against two different human cancer cell lines cervical cancer and lymphoma. Then they chose the best 25 to test against three additional lines, from lung, kidney and breast tumors. Overall, dimeric compounds those with two ETP molecules joined together appeared to be more effective at killing cancer cells than single molecules (known as monomers).

The structure of an ETP natural product typically has at least one set of fused rings containing one or more sulfur atoms that link to a six-member ring known as a cyclo-dipeptide. The researchers found that another key to tumor-killing ability is the arrangement and number of these sulfur atoms: Compounds with at least two sulfur atoms were the most effective, those with only one sulfur atom were less effective, and those without sulfur did not kill tumor cells efficiently.

Other rings typically have chemical groups of varying sizes attached in certain positions; a key position is that next to the ETP ring. The researchers found that the larger this group, the more powerful the compound was against cancer.

The compounds that kill cancer cells appear to be very selective, destroying them 1,000 times more effectively than they kill healthy blood cells.

The researchers also identified sections of the compounds that can be altered without discernably changing their activity. This is useful because it could allow chemists to use those points to attach the compounds to a delivery agent such as an antibody that would target them to cancer cells, without impairing their cancer-killing ability.

Complex synthesis

Now that they have some initial data, the researchers can use their findings to design additional compounds that
'/>"/>

Contact: Sarah McDonnell
s_mcd@mit.edu
617-827-7637
Massachusetts Institute of Technology
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. U.S. Teen Birth Rates Highest in Rural Areas, Research Shows
2. Pessimism about the future may lead to longer, healthier life, research finds
3. Gut microbiota research: Pinpointing a moving target
4. Research suggests malaria can be defeated without a globally led eradication program
5. Researchers at the UH Cancer Center discover protein that may control the spread of cancer
6. Now hear this: Stanford researchers identify forerunners of inner-ear cells that enable hearing
7. Researchers explore PKC role in lung disease
8. Cleveland Clinic researcher receives grant to fund autism research
9. Bhatia honored by Southern Society for Pediatric Research
10. NIH awards $12.4 million grant to fund Henry Ford Hospital hypertension research
11. RWJF awards $1.9 million grant to PatientsLikeMe to create open research platform
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... Johns Hopkins University School of Medicine researchers have been ... for diabetes, Novo Nordisk announced this month. Of the ... and Obesity Biologics Science Forum Program, only four projects ... Hopkins researchers. They are Jonathan Powell, M.D., Ph.D.; G. ... , Jonathan Powell, a professor of oncology, will use ...
(Date:4/18/2014)... . A ... A team led by Ludwik Leibler from the Laboratoire ... Letourneur from the Laboratoire Recherche Vasculaire Translationnelle (INSERM/Universits Paris ... principle of adhesion by aqueous solutions of nanoparticles can ... tissues. This easy-to-use gluing method has been tested on ...
(Date:4/17/2014)... new pain relief targets that could be used ... at King,s College London made the discovery when ... periphery of the body. , Dr Marzia Malcangio ... underlying pain generation and our findings could help ... , One potential side effect of some chemotherapy ...
(Date:4/17/2014)... AURORA, Colo. (April 17, 2014) Two recent ... Medicine researcher and colleagues may help scientists develop ... virus, Yellow fever, Japanese encephalitis and other disease-causing ... of biochemistry and molecular genetics at the School ... the Howard Hughes Medical Institute, and colleagues recently ...
(Date:4/17/2014)... Il. (April 17, 2014) Doctors who treat ... called lymphangioleiomyomatosis (LAM) can face an agonizing treatment ... of the disease and help relieve shortness of ... transplants, and sirolimus can cause potentially fatal complications ... pulmonologist Dr. Daniel Dilling, medical director of Loyola ...
Breaking Medicine News(10 mins):Health News:Innovative strategy to facilitate organ repair 2Health News:Innovative strategy to facilitate organ repair 3Health News:New pain relief targets discovered 2Health News:CU researchers discover target for treating dengue fever 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3
... recently approved anti-smoking medication could also serve to repress ... study by researchers at the University of California-San Francisco ... as a smoking cessation aid in the United States ... nicotine consumption by affecting the brain's reward system for ...
... HIV sufferers with free anti-retroviral drugs by the end of year, ... . ,"We are close to 110,000 people on ARVs ... when we launch a massive scale-up of the drugs" from September, ... be underwritten by a new batch of funding from the global ...
... fever killed 30 people in Myanmar in the first six months ... country in the region to experience a surge in the ... official, told the weekly Myanmar Times newspaper that the number of ... this year there have been about 3,000 cases of the disease ...
... Medical Center have demonstrated conclusively that a specific protein ... and remyelination, processes essential to the creation and repair ... groundbreaking discovery in mouse models points the way to ... and/or brain disease repair in children and adults. The ...
... and the University of Michigan have discovered a gene ... ,In the current online issue of Nature ... nephronopthisis (NPHP) in humans and mice. NPHP is a ... to kidney failure requiring organ transplantation. The insights might ...
...
Cached Medicine News:Health News:Specific Protein is Instrumental in Myelination 2Health News:Specific Protein is Instrumental in Myelination 3Health News:New Therapies for Kidney Diseases 2
(Date:1/15/2014)... 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced ... Global Industry Analysis, Size, Share, Growth, Trends And Forecast, ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ) ... patients in order to treat dental impairments, for tooth ...
(Date:1/15/2014)... Jan. 15, 2014  Celsion Corporation (the "Company") (NASDAQ: ... from institutional investors to purchase an aggregate of approximately ... at-the-market registered direct offering, led by a dedicated health ... purchase agreements with these investors pursuant to which the ...
(Date:1/15/2014)... BreedIT Corp (OTC: BRDT), through its Israeli ... sophisticated agro-breeding solutions for plant breeders and researchers, today ... of directors appointed chemistry and pharmaceutical industry expert Dr. ... the board. From 1975 to 2012, Dr. ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3
... Disney Family Cancer Center will be the first cancer center on ... latest oncology products from Elekta , including ... , Rex Hoffman, M.D. is Medical Director of Radiation Oncology at ... Family Cancer Center will be located. He says the groundbreaking for ...
... CLARA, Calif., Oct. 27 Lumenis Ltd., a global ... devices for surgical, aesthetic, and ophthalmic applications, announced that ... to Lumenis stating that the PolyScope Flexible Endoscope can ... this 510K, the PolyScope is indicated in flexible endoscopic ...
Cached Medicine Technology:Elekta Provides Complete Planning, Treatment and Workflow Solution for Roy and Patricia Disney Family Cancer Center 2Elekta Provides Complete Planning, Treatment and Workflow Solution for Roy and Patricia Disney Family Cancer Center 3Lumenis Receives 510K Clearance for the PolyScope Disposable Flexible Endoscope 2Lumenis Receives 510K Clearance for the PolyScope Disposable Flexible Endoscope 3Lumenis Receives 510K Clearance for the PolyScope Disposable Flexible Endoscope 4
... Injectable was designed to provide the surgeon with ... of surgical complications during cataract and retinal surgery. ... small and medium sized pupils which allows expansion ... iris sphincter during surgery, and allows the pupil ...
... Flow Unit is a flexible, total solution. , ... operating theaters since 1983. A major part of ... extensive experience from all the different areas of ... , ,Kojair Tech Oy is a comprehensive supplier. ...
Provides stable positioning of the knee during surgery....
BRAT 2 Autologous Blood Recovery System gives performance, speed, versatility, and quality processing. , ,The BRAT 2 is now available with on-board Vacuum, programmability, plasma sequestration, Data...
Medicine Products: