Navigation Links
Research to shed new light on how statins benefit heart patients
Date:9/20/2007

A scientist at Leeds whose research is challenging conventional thinking on how the cholesterol-reducing drugs statins benefit cardiac patients, has secured funding to further investigate her findings.

Dr Sarah Calaghan from the Universitys Faculty of Biological Sciences has been awarded 80,000 from Heart Research UK to progress her preliminary evidence that statins are directly affecting the heart muscle cell.

For a long time the cardiovascular benefits of statins were considered to be due to reducing cholesterol in the blood, which prevents the build-up of plaques in arteries - a major cause of heart attacks and strokes. But more recently its becoming clear that this is not the only way statins work, she says.

The widely acclaimed family of drugs are known to have beneficial effects for patients at risk of cardiovascular disease and those with established cardiovascular disease, saving up to 9,000 lives a year(1).

Dr Calaghans research suggests that statins are actually having a direct effect on heart cells, specifically the caveolae - tiny indentations in the cell membrane. Caveolae contain signalling molecules that Dr Calaghan has shown to have an active role in controlling the pumping mechanism of the heart.

Caveolae need cholesterol to exist and our research has shown that if cholesterol is removed from the membrane then the caveolae will collapse. This disrupts the function of caveolae-based signalling molecules and affects the hearts pumping mechanism and its ability to change its force of contraction, she explains.

In a healthy person, the hearts rate and force of contraction is increased by adrenaline during exercise or stress producing what is known as the fight or flight response.

We know that statins are beneficial, says Dr Calaghan. But its really important to know exactly why and how they are affecting the heart cells, since the hearts of patients with cardiac disease respond differently t
'/>"/>

Contact: Jo Kelly
jokelly@campuspr.co.uk
44-113-258-9880
University of Leeds
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Stem cell research- now Nobel Laureates join the debate
3. Researchers urge caution in using ear tube surgery
4. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
5. Spouses and other partners lower blood pressure says new research
6. Researchers Scale to assess the Severity of Epilepsy in Kids
7. More Research Required For COPD
8. Researchers identify the early makers of Neonatal Sepsis
9. OHSU Researchers Announce New Discovery
10. Skin Cancer Research To Go Global
11. Researchers Identify Gene Connected To Bipolar Disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/27/2015)... York, New York (PRWEB) March 27, 2015 ... ( http://www.lipitorlawsuitcenter.com/ ) that allege the statin medication increases ... diabetes has granted Pfizer Inc.’s Motion to Dismiss four ... According to a Case Management Order issued in the ... 23rd, the Court determined that the dismissals were warranted ...
(Date:3/27/2015)... First Choice Emergency Room opened its new ... 12665 W Lake Houston Pkwy, Houston, Texas and is open ... forward to delivering the highest quality emergency medical care to ... First Choice Emergency Room Summerwood. , To celebrate ... Summer Creek High School at First Choice Emergency Room’s ribbon ...
(Date:3/27/2015)... 27, 2015 Bleeding is one ... percutaneous coronary intervention (PCI), resulting in increased mortality, ... “risk-treatment paradox,” in which the highest-risk PCI patients ... treated less often with bleeding avoidance strategies than ... Mid America Heart Institute asked the question whether ...
(Date:3/27/2015)... New York, NY (PRWEB) March 27, 2015 ... is seeing more plastic surgery patients travel to the ... Tania Medina. The plastic surgery clinic is turning the ... for international cosmetic surgery patients — with trustworthy services ... important factor when selecting a plastic surgeon. Patients are ...
(Date:3/27/2015)... (PRWEB) March 27, 2015 Healthpointe is ... G. Katz, M.D., is now treating knee and hip ... Anaheim , Long Beach, and La Mirada. Dr. ... acute knee and hip joint disorders as well as ... is passionate in returning his patients back to their ...
Breaking Medicine News(10 mins):Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 2Health News:Lipitor Lawsuits Move Forward in Federal Multidistrict Litigation, as Court Rules on Pfizer’s Motion to Dismiss Certain Cases 3Health News:First Choice Emergency Room Opens New Facility in Houston, Texas 2Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 2Health News:Precision Medicine Improves Use of Bleeding Avoidance Strategies and Reduces Bleeding in Patients Undergoing Percutaneous Coronary Intervention 3Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 2Health News:Dominican Republic Plastic Surgery Provider Turning Medical Tourism Upside-Down 3Health News:Fellowship-Trained and Board-Certified Orthopedic Surgeon is Now Treating Knee and Hip Joint Disorders in Anaheim, California 2Health News:Fellowship-Trained and Board-Certified Orthopedic Surgeon is Now Treating Knee and Hip Joint Disorders in Anaheim, California 3
... zeroed in on a crucial gene, thought to be ... resistance// to long-term estrogen deprivation. The gene may be ... reappearance, and would enable a good idea to specialists ... research targeted breast cancer cells which had developed resistance ...
... The comradeship between doctors and medical representatives needs no ... the precincts of swank offices and boardrooms, where jet-setting ... targets. Propelled into action by sheer bottom-line figures, the ... doctor’s heart. ,The medical representatives first create ...
... to eat more by seeing the food ads on television, ... children// are more vulnerable to it. ,Researchers ... on Obesity in Budapest, said they exposed a group of ... series of food and toy adverts on television, followed by ...
... bird flu is also struggling to ensure that poor countries get ... ,Since the first case was reported two years ago, ... Indonesia - more than a third of the world's total. ... bird flu virus with the World Health Organization (WHO) since January. ...
... to bridge the gap in understanding schizophrenia, which affects ... how two of the dozen or more genes previously ... ,Prior genetic studies had linked schizophrenia to the ... in brain development, and erbB4, a receptor on brain ...
... School and the government of Kenya has jointly ... Food and Nutrition// Policy. The Friedman team, led ... Friedman School, is assisting the Kenyan government with ... plan. The scope of the plan ranges from ...
Cached Medicine News:Health News:Art of Establishing a Bond to Sell a Brand – Medical Reps Show the Wa 2Health News:Food Ads Prompts Children to Eat More 2Health News:Indonesia Struggles Against Bird Flu and the Drug Industry as Well 2Health News:Understanding of Schizophrenia Could Lead to New Treatment Options 2Health News:Understanding of Schizophrenia Could Lead to New Treatment Options 3Health News:Kenya to Implement National Food and Nutrition Policy 2Health News:Kenya to Implement National Food and Nutrition Policy 3
(Date:3/27/2015)... , March 27, 2015 Dynatronics Corporation (NASDAQ: ... has been appointed to the Company,s Board of Directors ... the death in November 2014 of board member Joseph ... Linder to our Board of Directors represents an important ... , chairman and president of Dynatronics.  "Rich is a proven ...
(Date:3/27/2015)... 2015 /CNW Telbec/ - Russell Williams , President ... (Rx&D), welcomes the 2015-2016 Quebec Budget, noting the fiscal ... the biopharmaceutical industry. However, the association is concerned about ... commend the government,s intent to strive for a balanced ... promote Quebec,s economic development is ...
(Date:3/27/2015)...  Holographic Optical Technologies of Augusta, Georgia ... imaging, is entering the world of consumer electronics with ... 20 th , 2015, the campaign will introduce the ... 22-inch displays will allow consumers to view fully three ... addition to the two displays, the company will also ...
Breaking Medicine Technology:Dynatronics Announces Appointment of Richard J. Linder to Board of Directors 2Quebec 2015-2016 Budget: Rx&D welcomes fiscal discipline and biopharma working group, but the decrease in government spending on medicines is questioned 2Quebec 2015-2016 Budget: Rx&D welcomes fiscal discipline and biopharma working group, but the decrease in government spending on medicines is questioned 3Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 2Holographic Optical Technologies brings cutting-edge holograms to consumer market through upcoming Kickstarter campaign 3
... SOMERSET, N.J., Jan. 30 Alfacell Corporation,(Nasdaq: ACEL ... occurred in the Phase IIIb clinical trial of its ... malignant,mesothelioma. Enrollment in the ONCONASE Phase IIIb clinical trial ... patients were enrolled in the,trial., In accordance with ...
... Breast ... Cancer Patients, EVERGREEN PARK, ... Centers in Evergreen Park, Illinois, near Chicago,( http://www.PursuingPainFreeCancer.org/breastcancer ), has announced ... for the,treatment of early stage breast cancer. The study involves the ...
Cached Medicine Technology:Alfacell Updates Status of ONCONASE(R) Phase III Clinical Program 2Breast Cancer Treatment Is Reduced to One Week 2
VascoScrew is a low profile unipolar pacing lead with a fixed screw for permanent pacing. Due to latest technologies, VascoScrew 6/60 M is compatible to all pacemaker-cavities with the size of IS-1 (...
The VascoTip J 9/60 PU is a unipolar tined, J-preformed permanent pacing lead. Due to advanced technology, VascoTip J 9/60 PU M is compatible to all pacemaker-cavities with the size of IS-1 (3.2 mm),...
... Tendril SDX is one ... pacing leads. Implantable with a ... reduced body diameter is designed ... venous obstruction and allow introduction ...
Tendril DX active-fixation leads allows for lower thresholds initially and during the lead maturation phase....
Medicine Products: