Navigation Links
Research to lead to brain tumor therapies
Date:3/24/2008

Unique human in vitro model (cell culture) research currently underway at the Peninsula Medical School in the South West of England is set to identify and develop therapies for the treatment of multiple tumours in the brain.

The tumours are caused by mutations affecting a protein called merlin, which in turn cause cancers in a range of cell types including Schwann cells in the brain. Schwann cells produce the sheaths that surround and insulate neurons.

Although the tumours are benign, they are frequent, can be inherited and come in numbers. The sheer number of them can overwhelm a patient, often leading to deafness and eventually death. Patients can suffer from 20 to 30 tumours at any one time, and the condition typically affects older children and adults.

No therapy, other than invasive surgery aiming at a single tumour and which may not eradicate the full extent of the tumours, exists.

The condition of multiple tumours is known as neurofibromatosis type two (NF2) and affects one in every 2,500 people worldwide. It can affect any family, regardless of past history, through gene mutation and currently there is no cure.

Research at the Peninsula Medical School is led by Professor Oliver Hanemann. By working with human cells in vitro, Professor Hanemann and his team are able to find new therapeutic targets for NF2. They have secured initial success by re-profiling an existing drug, sorafenib, and because they are using the human in cell culture model and re-profile new cancer drugs they do not need to carry out huge toxicity studies which means they now can go straight to clinical trials and introduce therapies to patients sooner rather than later using sorafenib or similar drugs.

Said Professor Hanemann: Ours is a unique model and a unique approach to the issue. We are on the verge of working with inpatient clinics to trial our latest breakthrough, and we are investigating other therapeutic targets using oth
'/>"/>

Contact: Andrew Gould
media@pr-works.co.uk
44-139-268-6107
The Peninsula College of Medicine and Dentistry
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New Research Uncovers How to Build and Maintain an Effective Competitive Intelligence Group
2. Molecular science could further improve leukemia survival, say St. Jude researchers
3. Stanford researchers unmask proteins in telomerase, a substance that enables cancer
4. Recognizing outstanding young researchers
5. Human-Research Protection Program at Fred Hutchinson Cancer Research Center Receives National Accreditation
6. Researchers sharpen search for new marine medicines with novel techniques
7. Research on consequences: Hyperactive girls face problems as adults
8. Senior Obama Strategist David Axelrod and Wife Susan to be Honored for Their Decade-Long Commitment to Epilepsy Research at NYC Benefit
9. Global Sound Conference Brings Worlds Top Sound Researchers, Technologists and Musicians to Los Angeles for Four Day Symposium
10. Exploring the Aaah ... $1 Million Grant Advances Aquatic Health Research
11. Queensland researchers get the latest tools to fight cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/12/2014)... United Arab Emirates (PRWEB) July 12, 2014 ... another Los Angeles basketball legend is heading to the ... scorer and six-time champion will be in the UAE ... & Fitness Weekend in support of diabetes awareness. The ... an award-winning entertainment marketing and event management company based ...
(Date:7/12/2014)... Amarillo, Texas (PRWEB) July 12, 2014 ... and Breastfeeding Made Simple as a valuable new resource ... that roughly two-thirds of American women work away from ... many sources touting the benefits of breastfeeding, but often ... continuing to nurse their babies. With its evidence-based insights, ...
(Date:7/12/2014)... Restore My Vision Today is a new ... couple boasting very impressive credentials on the field of ... as a way to help consumers do without the ... respective patients’ treatments . , In particular, ... of pertinent information relevant to eye care like:, ...
(Date:7/12/2014)... 2014 Maxim Peptide, a website that ... used solely in scientific experiments, is currently celebrating its ... business, Maxim Peptide, which was created by the founders ... and updated website that now features a special deals ... updated with fascinating articles about peptide research, including a ...
(Date:7/12/2014)... 12, 2014 Ladies, it doesn't matter what ... Those who are looking for an affordable gown can ... occasion dresses) to get their dream items. Recently, the company ... length gowns . Along with that, it is also providing ... the special offer; the deadline of this promotion is July ...
Breaking Medicine News(10 mins):Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Praeclarus Press Announces the Release of Working and Breastfeeding Made Simple by Nancy Mohrbacher, A Much Needed Resource For Today's Working Mothers 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 2Health News:Restore My Vision Today | Groundbreaking Book Reveals How To Restore Your Vision Without The Use of Glasses – Vinamy 3Health News:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2Health News:Worldwide Brides-to-be: It Is Time To Show Your Beauty By Wearing A Trendy Summer Short Wedding Dress From Discount-Dress.com 2
... of Northwestern University, is a super sleuth of potentially ... team of doctors called RADAR (Research on Adverse ... School of Medicine. They swoop in to investigate early ... Administration (FDA) takes notice. ,A new study ...
... Court on Friday announced that it has accepted a ... to review the constitutionality of a Mexico City law ... the first three months' gestation, the Los Angeles Times ... Democratic Revolution in March in the Mexico City Legislature ...
... such as Girls Aloud, Pussycat Dolls and the Sugababes have ... promoting an ideal for what a womans figure should look ... ,Researchers from the universities of Leeds and Sussex ... where all the band-members are skinny, found that watching such ...
... in Physiological and Biochemical Zoology, a fascinating new ... evolution and artificial selection, providing insight into ... fluctuations. ,Dr. James Hicks, Editor in ... collection of papers: "This exciting approach experimental ...
... good for the fairer sex, for a new study has found that ... as fast as if she has just had a grueling workout. ... a group of 35 women and found that trying on a pair ... beats per minute. ,And, this is not just a one ...
... up boozing from home. ,Based on this, ... away from their middle school children, the best place to ... by a team of researchers including principal investigator Kelli Komro ... Minnesota, Minneapolis. ,As part of the study, researchers ...
Cached Medicine News:Health News:Researchers Found Drug Effects of Deadly Prescription Well Before FDA 2Health News:Researchers Found Drug Effects of Deadly Prescription Well Before FDA 3Health News:Mexico Supreme Court Accepts Petition To Review Mexico City Law Legalizing Abortion During First Three Months' Gestation 2Health News:Research Throws Light on Adaptation of E.coli to Changing Conditions 2
(Date:1/15/2014)... 2014  Research and Markets ( http://www.researchandmarkets.com/research/6k27gw/dental ) has announced ... Global Industry Analysis, Size, Share, Growth, Trends And Forecast, ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769 ) ... patients in order to treat dental impairments, for tooth ...
(Date:1/15/2014)... 15, 2014 AARP Foundation today announced it has established ... from the severe cold weather that has gripped much of ... those in need; so to support these emergency relief efforts ... $250,000, which could mean up to $500,000 in aid. The ...
(Date:1/15/2014)... Corporation (the "Company") (NASDAQ: CLSN ) today ... to purchase an aggregate of approximately $15 million of ... offering, led by a dedicated health care fund. ... these investors pursuant to which the Company agreed to ...
Breaking Medicine Technology:Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 2Dental Consumables Market - Global Industry Analysis, Size, Share, Growth, Trends And Forecast, 2013 - 2018 3AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 2Celsion Corporation Announces $15 Million At-The-Market Registered Direct Offering 3
... 23, 2011  Dune Medical Devices announced today the ... and Chief Financial Officer, effective immediately.  Mr. Blanchette ... Officer of Cadent, Inc. through Cadent,s acquisition by ... Mr. Blanchette has served in a variety of ...
... Nov. 23, 2011 Endo Pharmaceuticals (Nasdaq: ENDP ... chief financial officer will present a corporate overview at the ... Thursday, December 1, 2011 at 7:30 a.m. ET.  The conference ... Orlando, FL. A live webcast and audio archive ...
Cached Medicine Technology:Dune Medical Announces Appointment of Roger Blanchette as Chief Financial Officer 2
... includes three major components: Blood pump, Cannulae, ... Driver. This system provides partial or total ... conventional therapy, is unable to maintain adequate ... support, blood flows from the natural heart ...
Datascope presents a unique new product for post-hemostasis puncture site management. Safeguard is the first product ever to combine a built-in inflatable bulb and a sterile dressing- providing adjus...
... catheter is inserted into the subclavian or ... vena cava. The Cool Line incorporates ... temperature-controlled saline flowing within a closed-loop design, ... circulation. The Cool Line combines two ...
... The Fortius catheter provides maximum ... to target temperature. The Fortius catheter ... design to provide the ultimate solution ... catheter is inserted percutaneously into the ...
Medicine Products: