Navigation Links
Research to lead to brain tumor therapies
Date:3/24/2008

Unique human in vitro model (cell culture) research currently underway at the Peninsula Medical School in the South West of England is set to identify and develop therapies for the treatment of multiple tumours in the brain.

The tumours are caused by mutations affecting a protein called merlin, which in turn cause cancers in a range of cell types including Schwann cells in the brain. Schwann cells produce the sheaths that surround and insulate neurons.

Although the tumours are benign, they are frequent, can be inherited and come in numbers. The sheer number of them can overwhelm a patient, often leading to deafness and eventually death. Patients can suffer from 20 to 30 tumours at any one time, and the condition typically affects older children and adults.

No therapy, other than invasive surgery aiming at a single tumour and which may not eradicate the full extent of the tumours, exists.

The condition of multiple tumours is known as neurofibromatosis type two (NF2) and affects one in every 2,500 people worldwide. It can affect any family, regardless of past history, through gene mutation and currently there is no cure.

Research at the Peninsula Medical School is led by Professor Oliver Hanemann. By working with human cells in vitro, Professor Hanemann and his team are able to find new therapeutic targets for NF2. They have secured initial success by re-profiling an existing drug, sorafenib, and because they are using the human in cell culture model and re-profile new cancer drugs they do not need to carry out huge toxicity studies which means they now can go straight to clinical trials and introduce therapies to patients sooner rather than later using sorafenib or similar drugs.

Said Professor Hanemann: Ours is a unique model and a unique approach to the issue. We are on the verge of working with inpatient clinics to trial our latest breakthrough, and we are investigating other therapeutic targets using oth
'/>"/>

Contact: Andrew Gould
media@pr-works.co.uk
44-139-268-6107
The Peninsula College of Medicine and Dentistry
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. New Research Uncovers How to Build and Maintain an Effective Competitive Intelligence Group
2. Molecular science could further improve leukemia survival, say St. Jude researchers
3. Stanford researchers unmask proteins in telomerase, a substance that enables cancer
4. Recognizing outstanding young researchers
5. Human-Research Protection Program at Fred Hutchinson Cancer Research Center Receives National Accreditation
6. Researchers sharpen search for new marine medicines with novel techniques
7. Research on consequences: Hyperactive girls face problems as adults
8. Senior Obama Strategist David Axelrod and Wife Susan to be Honored for Their Decade-Long Commitment to Epilepsy Research at NYC Benefit
9. Global Sound Conference Brings Worlds Top Sound Researchers, Technologists and Musicians to Los Angeles for Four Day Symposium
10. Exploring the Aaah ... $1 Million Grant Advances Aquatic Health Research
11. Queensland researchers get the latest tools to fight cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/14/2009)... bump in odds is small and shouldn,t worry most ... -- Older women who take antidepressants may have a ... death compared to women not on the medications, a ... different from clinical significance," stressed Dr. Jordan W. Smoller, ... and lead author of a report in the Dec. ...
(Date:12/14/2009)... 2 diabetes and obesity are linked to an increased ... that insulin glargine (a synthetic insulin preparation marketed under ... higher risk of certain cancers than other insulins or ... unable to control for important factors such as obesity ... the other hand, a large randomized trial designed to ...
(Date:12/14/2009)... functioning , , , MONDAY, Dec. 14 (HealthDay News) -- ... live longer than those who look older than their ... from research that involved 1,826 Danish twins, aged 70 ... and then had their faces photographed. Three groups of ... they perceived the participants to be. Twins were assessed ...
(Date:12/14/2009)... and the United Nations Foundation’s Nothing But Nets tipped off a ... HP--to send anti-malaria bed nets to refugees in 11 African countries. ... and runs through January 31, 2010. , ... ... National Basketball Association (NBA) and the United Nations Foundation’s Nothing But ...
(Date:12/14/2009)... Concetta F. Conkling of Moraga, CA, retired ... has been elected Chair of the Board of Trustees ... the nearly 90-year-old organization to which Helen Keller devoted ... York with offices in San Francisco, Dallas, ... is dedicated to expanding possibilities for people with vision ...
Breaking Medicine News(10 mins):Health News:Antidepressants May Raise Women's Stroke Risk 2Health News:Antidepressants May Raise Women's Stroke Risk 3Health News:UNC scientists coordinate study of link between insulin use and cancer in people with diabetes 2Health News:Looking Younger Than Your Age May Mean Longer Life 2Health News:NBA Cares and United Nations Foundation Partner to Launch Send A Net. Save A Life. See A Game. Presented By HP 2Health News:NBA Cares and United Nations Foundation Partner to Launch Send A Net. Save A Life. See A Game. Presented By HP 3Health News:NBA Cares and United Nations Foundation Partner to Launch Send A Net. Save A Life. See A Game. Presented By HP 4Health News:The American Foundation for the Blind Welcomes New Board Chair, Concetta F. Conkling 2
... Society of Cardiology (ESC) is calling for concerted action ... the World Heart Organisation (WHO). // ... full extent of the global burden of chronic diseases ... is anticipated that a global action to prevent chronic ...
... upon the foods we eat, the products we buy, the ... we spend time // . Evaluation of stimulus valence is ... uses it as a basic category for organizing information and ... to be immediate, unintentional and linked to behavioral responses. ...
... agreement in principle to enable the smooth transfer of ... is an encouraging sign for Indian bioscience. But slow ... India’s grandiose scheme to become the global hub of ... of becoming a major player. , ,Discussions in ...
... alarming rise in human cases of bird flu, causing increasing ... strong resolve in the scientific community to combat this impending ... flu has risen since October 5 when scientists from the ... reported finding similarities between the bird flu strain in Asia, ...
... dream come true for the scientists who been working hard ... expected to take an extra step ahead as it is ... as well as their offspring, are safe to eat., ... techniques, with Canadian Scientists having proved themselves following the success ...
... against, a London based leading drug company, GlaxoSmithKline for ... to the U.S. Food and Drug Administration two years ... review. This became evident last November when The FDA ... , ,The Public Citizen Group has registered a ...
Other Medicine News:Health News:Conditioning preferences in children 2Health News:Biologicals Transfer Proposal between US and Indian Biotechnology 2Health News:FDA Mislead On Asthma Drug By GlaxoSmithKline 2
(Date:12/14/2009)... board of directors of Eli Lilly and Company (NYSE: ... the first quarter of 2010 of $0.49 a share ... is payable March 10, 2010 to shareholders of record ... 12, 2010. ,, Lilly, a leading innovation-driven corporation, is ... the latest research from its own worldwide laboratories and ...
(Date:12/14/2009)... Dec. 14 Zargis Medical Corp., a ... ) and a spin-off from Siemens Corporate Research ... it has begun selling its award-winning Zargis Cardioscan(TM) ... Cardioscan and its accompanying Bluetooth®-enabled electronic stethoscope were ... "2009 Innovation of the Year." Cardioscan ...
(Date:12/14/2009)... Gibraltar Associates, a leading public ... domestic communications and issues management, today announced ... PositiveID Corporation (Nasdaq: PSID ) to ... of record. Gibraltar Associates will conduct media ... the Company on its public relations programs. ...
Breaking Medicine Technology:Zargis Cardioscan 'The Intelligent Stethoscope' Now Available on Amazon.com 2Gibraltar Associates Named Agency of Record for Health Information and Diagnostic Provider PositiveID Corporation 2Philadelphia Born Ronald McDonald House 28R 29 Program Celebrates 35 Years 59433 1Philadelphia Born Ronald McDonald House 28R 29 Program Celebrates 35 Years 59433 2Philadelphia Born Ronald McDonald House 28R 29 Program Celebrates 35 Years 59433 3Bionovo Adds Dr Debu Tripathy to Their Medical Advisory Board 59431 1Bionovo Adds Dr Debu Tripathy to Their Medical Advisory Board 59431 2Bionovo Adds Dr Debu Tripathy to Their Medical Advisory Board 59431 3Dr Floyd Bloom Joins aTyr Pharmas Scientific Advisory Board 14466 1Dr Floyd Bloom Joins aTyr Pharmas Scientific Advisory Board 14466 2Dr Floyd Bloom Joins aTyr Pharmas Scientific Advisory Board 14466 3
... the new PRONEB® ULTRA compressor. This high ... while delivering more medication to the patient's ... PLUS® or PARI LC STAR® Reusable Nebulizer, ... for inhalation and retention into the lungs. ...
... Graham-Field has been developing diverse ... 58 years. Our medical-surgical products ... for innovation, quality and customer ... include the Labtron® line of ...
... TREK™ Compact Compressor is for active patients ... anywhere and everywhere. The compressor is small ... source optionsworldwide AC compatibility (100 to 240V), ... patients the freedom to take aerosol treatments ...
... ,Allied Healthcares Timeter® PCS 414 portable air compressor ... that you may wonder if its running. Youll ... a durable, mar-resistant steel case thats easy to ... 26.5 pounds. The PCS 414 has been engineered ...
Medicine Products: