Navigation Links
Research team identifies new mechanism with suspected role in cancer
Date:10/18/2010

PROVIDENCE, R.I. [Brown University] If women had no prolactin receptors on cells in their mammary glands, they would not produce milk when they were nursing. Prolactin receptors are also found in other organs including the lung and the colon. The only problem is that these receptors are sort of like cellular wiring, and when the wrong conditions bring them together, the resulting short circuit can produce cancer.

In new research published online Oct. 18, 2010, in the Proceedings of the National Academy of Science, a team led by researcheres at Brown University and Rhode Island Hospital has identified a key chemical process by which cells with prolactin receptors can sometimes take that turn for the worse.

That key step is called "acetylation" a chemical reaction inside the cell, triggered by the binding of the arrival of the prolactin hormone at the receptor. That process can draw prolactin receptors together into a structure called a "dimer." Like a pair of chopsticks, this dimer structure is just right to pick up growth factors in the body that can lead to cancerous growth, said Y. Eugene Chin, associate professor of surgery (research) in the Warren Alpert Medical School of Brown University, based at Rhode Island Hospital.

"Our findings may provide an important clue about how to develop drugs to break down receptor dimers in breast cancer therapy," said Chin, a senior author on the paper that also involved researchers from Zhejiang University School of Medicine in China and the University of Rochester in Rochester, N.Y.

Normally, a shared positive electrical charge and the resulting mutual repulsion keeps prolactin receptors from coming together. In their experiments, the team found that when prolactin binds to the receptors outside the cells, the acetylation neutralizes that charge on the receptors inside the cells, allowing the receptor molecules to come together, Chin said.

The more prolactin receptors a cell has, the more susceptible it is to this problem occurring, Chin said. Overexpression of prolactin receptors in patients has been linked to cancer in the past.

Chin, who has been investigating the molecular basis of cancer for years, said he is encouraged about uncovering this new step. He points to drugs, such as Herceptin, that target receptors to combat cancer.

"This will be extremely important for breast cancer and other cancer therapy by targeting receptors," he said.

One possibility will be developing monoclonal antibodies to target the prolactin receptors directly, he said. But artificial compounds could also be developed to block the receptors from joining as dimers.


'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2016)... ... 2016 , ... An April Gallup survey found rising health care costs to ... Sun Health Senior Living (SHSL) may not share those same worries thanks to ... for the year, while holding the line on increasing their contributions, including premiums, deductibles ...
(Date:5/26/2016)... ... May 26, 2016 , ... The Lung Institute has partnered with ... class starting June 6 at their clinic in downtown Tampa. The class is complimentary ... Lung Institute has created a free downloadable 4 Week Smoking Cessation Guide ...
(Date:5/26/2016)... ... 26, 2016 , ... Eugene Batelli, D.P.M., F.A.C.F.A.S, is celebrating ... accolades and stellar patient reviews, Dr. Batelli continues to be recognized for his ... is a highly trained Podiatric Surgeon who specializes in treating athletes and their ...
(Date:5/26/2016)... ... 2016 , ... A health conscious snack that doesn't sacrifice taste? It's possible! ... an undeniable buzz in the protein product community by offering an alternative to the ... are packed with 11 grams of protein and made from a healthy blend of ...
(Date:5/26/2016)... ... May 26, 2016 , ... May 2016 – Lips may ... to popular cosmetic improvement efforts. Record numbers of clients now ask about lip plumping ... pouty, says Kally Papantoniou, MD, of Advanced Dermatology P.C. , The trend ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)...   , Study met ... bowel cleansing and superiority in , ... of the ascending colon   ... Norgine B.V. today announced new positive data from the phase ... preparation) versus standard 2 litre PEG with ascorbate. The study met ...
(Date:5/24/2016)... May 24, 2016 ARANZ Medical ... the healthcare sector, has been named the Coretex Hi-Tech Emerging ... 2016. Dr Bruce Davey , CEO of ... team.  It,s really good to be recognised for the work ... products are used in 35 countries around the world from ...
(Date:5/24/2016)... N.J. , May 24, 2016 ... oncology drug development company, today provided an update ... dose escalating clinical trial combining GEN-1, the Company,s ... the treatment of newly-diagnosed patients with advanced ovarian ... interval debulking surgery.  GEN-1 is an IL-12 DNA ...
Breaking Medicine Technology: