Navigation Links
Research team identifies new mechanism with suspected role in cancer
Date:10/18/2010

PROVIDENCE, R.I. [Brown University] If women had no prolactin receptors on cells in their mammary glands, they would not produce milk when they were nursing. Prolactin receptors are also found in other organs including the lung and the colon. The only problem is that these receptors are sort of like cellular wiring, and when the wrong conditions bring them together, the resulting short circuit can produce cancer.

In new research published online Oct. 18, 2010, in the Proceedings of the National Academy of Science, a team led by researcheres at Brown University and Rhode Island Hospital has identified a key chemical process by which cells with prolactin receptors can sometimes take that turn for the worse.

That key step is called "acetylation" a chemical reaction inside the cell, triggered by the binding of the arrival of the prolactin hormone at the receptor. That process can draw prolactin receptors together into a structure called a "dimer." Like a pair of chopsticks, this dimer structure is just right to pick up growth factors in the body that can lead to cancerous growth, said Y. Eugene Chin, associate professor of surgery (research) in the Warren Alpert Medical School of Brown University, based at Rhode Island Hospital.

"Our findings may provide an important clue about how to develop drugs to break down receptor dimers in breast cancer therapy," said Chin, a senior author on the paper that also involved researchers from Zhejiang University School of Medicine in China and the University of Rochester in Rochester, N.Y.

Normally, a shared positive electrical charge and the resulting mutual repulsion keeps prolactin receptors from coming together. In their experiments, the team found that when prolactin binds to the receptors outside the cells, the acetylation neutralizes that charge on the receptors inside the cells, allowing the receptor molecules to come together, Chin said.

The more prolactin receptors a cell has, the more susceptible it is to this problem occurring, Chin said. Overexpression of prolactin receptors in patients has been linked to cancer in the past.

Chin, who has been investigating the molecular basis of cancer for years, said he is encouraged about uncovering this new step. He points to drugs, such as Herceptin, that target receptors to combat cancer.

"This will be extremely important for breast cancer and other cancer therapy by targeting receptors," he said.

One possibility will be developing monoclonal antibodies to target the prolactin receptors directly, he said. But artificial compounds could also be developed to block the receptors from joining as dimers.


'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Related medicine news :

1. Embedded Mobile & M2M Device revenues to Rise to Almost $19 Billion Globally by 2014, Says Juniper Research
2. 2010 HSR Impact Award recognizes surgical safety research
3. MSU launches first anti-counterfeiting research program
4. Researchers map all the fragile sites of the yeast Saccharomyces cerevisiaes genome
5. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
6. Researchers discover new way to kill pediatric brain tumors
7. Family Research Council: Planned Parenthood Report Oversexualizes Ten-Year-Olds, Undermines Parental Authority
8. Michael J. Fox Foundation Awards $1 Million to Drive Critical New Research Tools and Technologies in Parkinsons Drug Development
9. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
10. International Diabetes Federation awards $2 million to 9 global diabetes research projects
11. Gladstones Robert Mahley to receive Research!America advocacy award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... ... December 02, 2016 , ... The annual time frame to change Medicare health ... is ending December 7th. Currently-enrolled Medicare beneficiaries who are looking to switch from their ... D) need to make changes during this period order for their new policy to ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... More than ... and while 84 percent of parents report speaking with their child about sex related ... sexually transmitted diseases. , Mediaplanet is proud to announce the launch of its second ...
(Date:12/2/2016)... ... December 02, 2016 , ... Sourced from the Isbre Springs beneath the 5,000 ... unmatched natural purity of just 6 ppm TDS (Total Dissolved Solids) in addition to ... been available in several ShopRite and FoodTown stores in NJ and received rave comments ...
(Date:12/2/2016)... Miami, FL (PRWEB) , ... December 02, 2016 ... ... over 5,100 hot meals to needy individuals and families from eight different sites ... Florida on Thanksgiving Day. Over 1,000 volunteers worked very hard on Thanksgiving morning ...
(Date:11/30/2016)... , ... November 30, 2016 , ... ... they now offer a comprehensive in-house dental plan for all patients. Understanding that ... a plan that gives patients a number of perks, including discounts on many ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... YORK , December 2, 2016 ... Braces & Support) is Expected to Gain a Significant Market ... to Orthopedic Ailments  ... , According to ... Study on Medical Implants Sterile Packaging: Clamshell Product Type Segment ...
(Date:12/2/2016)... On Thursday, the NASDAQ Composite and ... the Dow Jones Industrial Average managed to stay in green. ... which prompted Stock-callers this morning to look at the performances ... NUVA ), Smith & Nephew PLC (NYSE: SNN ... Cesca Therapeutics Inc. (NASDAQ: KOOL ). You can ...
(Date:12/2/2016)... -- The concept of rare diseases and the idea that ... has been taking shape in Europe ... initiatives related to orphan medicinal products have been emerging at ... states individually. Many member states in the EU have led ... medicinal products, the result of which took the shape of ...
Breaking Medicine Technology: