Navigation Links
Research suggests that lipofilling may be safe during conservation treatment for breast cancer
Date:5/24/2011

A new study has gone some way to answering the question about whether or not a technique called lipofilling is safe for women who are having their breasts reconstructed after surgery for breast cancer.

Lipofilling involves taking some fat from another area of a woman's body, such as her abdomen, and using it to fill in small defects or asymmetry that may occur during breast reconstruction. However, until now, there has been a lack of evidence as to whether or not the technique could trigger a recurrence of the original breast cancer, and so plastic surgeons have not been able to advise patients fully on the pros and cons of lipofilling, despite the fact that it has been used for over 30 years.

Now, a study published in the cancer journal Annals of Oncology today [1] suggests that lipofilling seems to be a safe procedure for breast cancer patients, although the authors say that longer follow-up and more research is required in order to confirm their findings.

The researchers analysed data on 321 women who had been operated on for primary breast cancer at the European Institute of Oncology (IEO) in Milan, Italy, between 1997 and 2008, and who had then had lipofilling as part of their breast reconstruction. These women were matched with double the number (642) of women who had also had surgery for primary breast cancer, but who did not undergo lipofilling.

The researchers followed up the women for an average of 56 months from the time of the primary surgery and 26 months from the lipofilling. They found that eight women in the lipofillling group and 19 women in the control group had a local recurrence of their cancer a difference that was not statistically significant. When they analysed the data to look specifically at recurrences in women with non-invasive cancer (in situ cancer) they found there were three cases of recurrence in the lipofilling group and none in the control group; this was statistically significant, but may have been affected by the very small numbers involved, the short follow-up and the fact that there were no recurrences in the control group despite previous research suggesting there should be an average recurrence rate of over two percent during this period of time. "This indicates there might have been some bias in the selection of the women with non-invasive breast cancer in the control group," explained one of the authors, Professor Jean Yves Petit.

Prof Petit, from the Division of Plastic Surgery at the IEO in Milan, said: "To date, only a few studies have focused on cancer recurrences after lipofilling, and this is the first case-control study to investigate the question and the first publication to show the safety of the procedure. Our overall results do not find any difference in recurrences between the women in the lipofilling and control groups. However, it is still too early in the follow-up to be able to draw any definitive conclusions. We urge other teams working in the same field to gather their own results concerning local recurrences after lipofilling in breast conservation treatment."

This study is important because other, experimental work in the laboratory has shown that fatty tissue is capable of producing growth factors that can trigger cancer cells to multiply. This raised the question of whether this might happen in humans.

"Work by other researchers has shown that secretions from transplanted fat tissues can stimulate angiogenesis [the formation of new blood vessels] and cell growth," said Prof Petit. "In the laboratory the interaction between the tumour and stromal cells the connective tissue cells found in any organ has the potential to induce the reappearance of cancer by fuelling dormant breast cancer cells in the tumour bed, for example through angiogenesis and growth factor induction. However, until now, there has been a lack of translational research to prove whether or not this might happen in the clinic when lipofilling is used for breast cancer patients. Our study suggests that the procedure is safe for these women."


'/>"/>

Contact: Emma Mason
wordmason@mac.com
European Society for Medical Oncology
Source:Eurekalert

Related medicine news :

1. 24th ECNP Congress: The most promising data from research across brain disorders
2. MIT research: What makes an image memorable?
3. UTMB researcher receives $3 million NIH grant to study aging in Mexico
4. Researchers Find Cousin of Hepatitis C Virus in Dogs
5. Researchers discover link between obesity gene and breast cancer
6. Mount Sinai researchers discover possible new target for sarcoma treatment and prevention
7. Research provides insight into quality of stored blood used for transfusions
8. Caltech research helps paraplegic man stand and move legs voluntarily
9. Researchers connect electrical brain disturbances to worse outcomes following neurotrauma
10. Eat a protein-rich breakfast to reduce food cravings, prevent overeating later, researcher finds
11. Pitt researchers build a better mouse model to study depression
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... The preeminent surgical aftercare facility Pearl ... following breast cancer surgery. In March 2016, the 61-year-old model and reality TV star ... that occurs in the milk ducts, according to an interview with the Daily ...
(Date:5/4/2016)... ... 2016 , ... Warren L. Smith M.D. , There is a new tool ... people since the beginning of recorded medical history, and in spite of all the ... just a matter of inconvenience; bladder infections cost us billions of dollars annually in ...
(Date:5/4/2016)... ... May 04, 2016 , ... Over 40 athletic trainer’s (ATs) and athletic ... for the annual “Hike to Harrisburg” advocacy day. The annual lobbying effort is ... lobby Group. The goal for the day was to educate the elected legislators ...
(Date:5/3/2016)... ... May 04, 2016 , ... ... and global construction firms representing the Construction Industry Safety Initiative (CISI) and the ... one purpose: to inspire everyone in the industry to be leaders in safety. ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... In April, ... with today’s latest technologies to help find the best steam and sauna solutions. , ... device, using responsive design. This improvement brings all of the site’s features, especially the ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Research and Markets has ... Myeloma Market and Competitive Landscape Highlights - ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) , ... Highlights 2016, provides comprehensive insights into Multiple ... Myeloma market valuations and forecast, Multiple Myeloma ...
(Date:5/4/2016)... Research and Markets has ... Ischemic Stroke Market and Competitive Landscape Highlights ...      (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ) ... Market and Competitive Landscape Highlights 2016, provides ... products, Acute Ischemic Stroke epidemiology, Acute Ischemic ...
(Date:5/4/2016)... 4, 2016 Research ... "Global Acute Myeloid Leukemia Market and Competitive ... offering.       (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... Market and Competitive Landscape Highlights 2016, provides ... products, Acute Myeloid Leukemia epidemiology, Acute Myeloid ...
Breaking Medicine Technology: