Navigation Links
Research suggests popular diabetes drugs can cause abnormal pancreatic growth in humans
Date:3/27/2013

Individuals who had taken a type of drug commonly used to treat Type 2 diabetes showed abnormalities in the pancreas, including cell proliferation, that may be associated with an increased risk of neuroendocrine tumors, according to a new study by researchers from UCLA and the University of Florida. Their findings were published online March 22 in the journal Diabetes.

The researchers, from the Larry L. Hillblom Islet Research Center at UCLA and the Diabetes Center at the University of Florida, found that cell mass was increased approximately 40 percent in the pancreases of deceased organ donors who had Type 2 diabetes and who had been treated with incretin therapy. This widely used type of treatment takes advantage of the action of a gut hormone known as glucagon-like peptide 1 (GLP-1) to lower blood sugar in the body.

Although there have been conflicting reports on the effects of the incretin class of drugs on the pancreas in animal studies, this is the first study to note such changes in the human pancreas. The research was made possible by a unique research consortium called nPOD (Network for Pancreatic Organ Donors with Diabetes), led by Dr. Mark Atkinson, a professor of pathology and pediatrics at the University of Florida. The network, which is funded by the Juvenile Diabetes Research Foundation, obtains pancreases from deceased organ donors, with permission of their next of kin, to better understand diabetes by investigating tissues of those with the disease.

"There is an increasing appreciation that animal studies do not always predict findings in humans," said Dr. Peter Butler, director of UCLA's Hillblom Islet Research Center and chief of the endocrinology, diabetes and hypertension unit. "The nPOD program is therefore a very precious resource." The researchers examined the pancreases of 20 deceased organ donors with Type 2 diabetes. Eight had been treated for at least a year with incretin therapy, while th
'/>"/>

Contact: Enrique Rivero
erivero@mednet.ucla.edu
310-794-2273
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Frozen Food Production in the US Industry Market Research Report from IBISWorld has Been Updated
2. Moffitt researchers analyze HPV vaccination disparities among girls from low-income families
3. Penn research: Quitting marshmallow test can be a rational decision
4. Notre Dame researchers scoring a win-win with novel set of concussion diagnostic tools
5. GW professor researching ways to improve human tissue dissection, reduce blood transfusions
6. Researchers form new nerve cells &#8211 directly in the brain
7. Wake Forest Baptist research provides clues to alcohol addiction vulnerability
8. Research and Markets Announces the Release of Global Biobank (Biospecimen/Biorepository/Biopreservation) Market For Equipment & Media – Trends & Forecast to 2017
9. Moffitt Cancer Center researchers design small molecule to disrupt cancer-causing protein
10. UW researchers discover the brain origins of variation in pathological anxiety
11. Researchers decode biology of blood and iron disorders mapping out novel future therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... in the U.S. has led to public debate about ... alcohol. In January, President Obama also publically stated he ... alcohol. Despite the recent shift in views toward marijuana, ... are not well understood. , Now a ... among US High School Seniors: A Comparison of Alcohol ...
(Date:9/2/2014)... 2 September 2014: A simple awareness campaign in general ... to research presented at ESC Congress today by Professor ... fibrillation (AF) is the most common cardiac arrhythmia. It ... and the risk of stroke risk by five-fold. Similarly, ... 4 cases. However, AF is often overlooked and diagnosed ...
(Date:9/2/2014)... Aeroflow Healthcare, an industry leader and home medical ... of its new office to be located in Greer, ... Suite D, Greer, SC 29651. This new location will ... convenient location in the Greenville area. , “This is ... hospitals and patients we serve, to ensure that we ...
(Date:9/2/2014)... September 02, 2014 September 2014 – The ... gone. But even though men shave daily – and commit ... rough and irritated skin isn’t inevitable, according to Joshua ... , For decades, skin care was something in which ... surge in men of all ages who realize that their ...
(Date:9/1/2014)... Windows web hosting provides a Windows based server ... recent years, and the new demand has resulted in ... that offer a variety of different services at very ... professional Windows web hosting suppliers from the USA and ... suppliers for webmasters who want to buy high quality ...
Breaking Medicine News(10 mins):Health News:NYU study compares consequences of teen alcohol and marijuana use 2Health News:NYU study compares consequences of teen alcohol and marijuana use 3Health News:Simple awareness campaign in general practice identifies new cases of AF 2Health News:Aeroflow Healthcare Opens Office In Greer, SC To Service Greenville & Spartanburg Patients 2Health News:Rough Isn’t Rugged in Men’s Skin: Dermatology specialist Dr. Joshua Fox with Advanced Dermatology PC offers tips on easy skin maintenance for men 2Health News:Rough Isn’t Rugged in Men’s Skin: Dermatology specialist Dr. Joshua Fox with Advanced Dermatology PC offers tips on easy skin maintenance for men 3Health News:SEO Hosting Review Site Top10BestSEOHosting.com: Best Windows Web Hosting Suppliers From the USA Now Unveiled 2
... the breathing passage, which results due to smoking is ... 2020. // ,Called Chronic Obstructive Pulmonary ... chronic-obstructive bronchitis and emphysema of the lungs. ... swelling of the mucous membrane and emphysema decomposes lung ...
... urinalysis can reveal very much about the health condition ... simple diagnostic procedure should not be overlooked. // ... Prince Charles Hospital said by examining a patient's urine ... taking certain medications or were being over-administered, reported ABC ...
... breast cancer victims is denied by the NHS to victims ... private medical insurers have saved their day by pitching in. ... available this drug to almost 100 women, who have been ... the drug available in 30 such cases. ,It ...
... appropriate climate where new ideas can thrive. But it ... There are a variety of social problems. To solve ... and resources. Collaboration is an essential element that holds ... application for the resulting discovery. Collaboration should be among ...
... in favor of the rise in Medicare bulk billing, which ... Federal Health Minister Tony Abbott released some alarming statistics that ... nationally. ,According to Dr Kim Bulwinkel, from AMA ... seeing more patients, in order to make it a feasible ...
... (HFM) disease has taken the life of another 14-month-old toddler in ... Sarawak has reached six since the outbreak. ,Deputy Chief ... a total of 82 children have been admitted to hospitals for ... state Disaster Management Committee, said that about 213 new cases were ...
Cached Medicine News:Health News:Colour Of Urine Can Reveal The Health Status Of The Patients 2Health News:Health Care System in US Needs a Change 2
(Date:8/29/2014)... HILL, N.C. , Aug. 29, 2014 ... Leaders (KOLs) can be the difference between a product,s ... to effectively map and stratify KOL targets – and ... build the type of strong relationships upon which successful ... research, savvy pharma companies have identified internal inconsistencies in ...
(Date:8/29/2014)... 29, 2014 /PRNewswire-iReach/ -- SAM Medical Products Implements ... the SAM Junctional Tourniquet.  Photo ... Medical Products announced today that it has begun ... a potential issue with a clip used to ... application of the SAM Junctional Tourniquet (SJT).  The ...
(Date:8/29/2014)... 2014  A Boston Scientific Corporation (NYSE: ... removability and preliminary long term stricture resolution of ... August issue of the peer-reviewed journal, Gastroenterology. ... being conducted in 11 countries and five continents, ... stents (FCSEMS) after extended indwell (i.e., up to ...
Breaking Medicine Technology:Implementing a Strategic Thought Leader Management & Engagement System 2SAM Medical Products Implements Voluntary Recall of its Accessory (Axilla) Strap for the SAM Junctional Tourniquet. 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 2Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 3Boston Scientific Study Published In Gastroenterology Reports Successful Management Of Benign Biliary Strictures With Fully Covered Metal Stents 4
... LAKES, N.J., Feb. 21, 2012 Fourth-Quarter ... share (EPS) of $1.08 increased 22.7 percent; Diluted EPS ... the pending merger with Express Scripts, Inc., increased 29.5 ... diluted EPS, excluding all intangible amortization and merger-related expenses, ...
... Amsterdam Molecular Therapeutics (Euronext: AMT), a ... announced today that it has received a request ... Medicinal Products (CHMP) on Glybera® (alipogene tiparvovec) by March ... on January 30, 2012 that the European Commission ...
Cached Medicine Technology:Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 2Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 3Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 4Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 5Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 6Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 7Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 8Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 9Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 10Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 11Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 12Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 13Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 14Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 15Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 16Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 17Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 18Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 19Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 20Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 21Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 22Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 23Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 24Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 25Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 26Medco Delivers Record Fourth-Quarter and Full-Year 2011 Earnings 27Amsterdam Molecular Therapeutics Receives Request for Further Information From CHMP on Glybera® 2Amsterdam Molecular Therapeutics Receives Request for Further Information From CHMP on Glybera® 3Amsterdam Molecular Therapeutics Receives Request for Further Information From CHMP on Glybera® 4
... the worlds leading medical technology company ... management for more than a decade, ... Timer. The ACT Plus System is ... to determine coagulation endpoints in whole ...
... techniques have largely replaced the use of plates and ... use of rods or pins in the forearm or ... been no way to lock the pins or hold ... non-locked nail is back out of the implant. The ...
... Atlas+ HF ICD is designed to provide the ... quality of life. The Atlas+ HF ICD is ... therapy (CRT), and it packs its power into ... can. In addition to its high energy, the ...
... Tibial Nail System is designed ... of existing implants and expand ... nails. It is available in ... and lengths and can be ...
Medicine Products: