Navigation Links
Research suggests new treatment suitable for all patients
Date:12/31/2007

enefits to patients, and newer generations are in development. The team is working to develop a drug to target a third marker (Fra-1).

GBM tumors are often resistant to current treatments, including chemotherapy and radiation therapy. The mean survival rate of patients with GBM is about 14 months and has improved only slightly over the past decades.

"Developing molecularly targeted therapies using genetically engineered bacterial toxins represents an attractive option that may improve outcomes," said Debinski.

The fact that the three markers were not found in healthy brain tissue suggests that the proteins are highly suited as targets for therapies designed to kill cancer cells and spare healthy brain tissue. In Molecular Cancer Therapeutics, the team reported success creating a drug to kill cancer cells that have high levels of EphA2. The drug, which would be delivered by catheters directly to the tumor, was created by chemically linking a protein that binds to EphA2 with a modified bacterial toxin.

In the laboratory, the treatment potently killed all of the over-expressing EphA2 cells within 48 hours. It was also effective at reducing tumors in mice. The researchers compared the treatment's potency to the drug Debinski had previously developed to target cells that express IL-13R2.

"Both were extremely effective and highly potent," said Debinski. "Some of the tumor cells responded to the IL-13 cytotoxin, some responded to EphA2-targeted cytotoxin and some responded to both. This illustrates why we need a cocktail to cover as many patients as possible."

He said this combination treatment might also apply to breast, pancreas and prostate cancers, which also have high levels of these proteins.

The third marker, Fra-1, is believed to control the malignant features of brain tumor cells, such as the development new blood vessels to "feed" the tumor.

An additional benefit of targeting the three proteins is that the drug cocktail affects
'/>"/>

Contact: Shannon Koontz
shkoontz@wfubmc.edu
336-716-2415
Wake Forest University Baptist Medical Center
Source:Eurekalert

0

GOOD

Page: 1 2 3

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/23/2013)... Nashville, TN (PRWEB) May 23, 2013 ... to enhance nurse understanding of the professional role and ... , Roland Joy, vice president of patient care services ... explains, "TAMC nurses are excellent clinicians, and we want ... profession, teach them that to lead they must follow, ...
(Date:5/23/2013)... PhD Box has introduced a ... the research process by offering assistance for Thesis Proposals. The ... of services that the company provides for research consultation in ... dedicated proposal writing service is that this is the stage ... research process find it difficult to draft a proposal as ...
(Date:5/23/2013)... Following the recent outbreak of fake ... the security team at idcloak Technologies has identified a ... or any web-born malware. Gill-Chris Welles of the ... better privacy and security than traditional antivirus ... the best AV software cannot be depended on: it ...
(Date:5/23/2013)... When Teachers Notebook reached out to its teacher ... the Moore, OK tornado victims, they hoped to attract ... be sold for around $10.00 with all proceeds benefiting ... were overwhelmed by the response from these dedicated educators ... the first 12 hours of the campaign. , Later ...
(Date:5/23/2013)... GBI Research’s analysis indicates that the global critical ... number of players accounting for a major proportion of the ... rate between 2006 and 2012, possibly due to the lack ... especially in the US. , GBI Research estimates that ... in 2012, having grown in size at a CAGR of ...
Breaking Medicine News(10 mins):Health News:OnSomble, Inc. Partners with The Aroostook Medical Center to Enhance Nurse Understanding of the Professional Role 2Health News:PhD Box Unveils Proposal Writing Services for Research Scholars 2Health News:Effective virus protection without anti-virus software, identifies idcloak 2Health News:Teachers Rally to Raise Funds for Moore Tornado Victims 2Health News:MarketResearch.com Report – Increased Cost of Albumin was Main Factor for Double-Digit Growth of Global Critical Care Market Between 2006 and 2012 2
... no open choices. But does this also mean no end-of life ... The department of health recently spoke of 60% compliance of ... elderly. ,To research into this lofty claim, a survey ... lives, often die a lonely death. Nearly 50% of the 800 ...
... this bit of news sent you into an instant cardio-vascular ... soil and the rest, who probably don’t engage// in heart ... ill health. This region portraying a high incidence of cardiovascular ... ,A major health initiative is taking shape under the ...
... can be treated in a short time if diagnosed properly. ... Body CT, the ultrasound technology could be used to accurately ... ,One condition that many runners seek treatment for ... the heel, caused by the back of the shoe consistently ...
... weighed less than 1lb 6oz. He was so weak that he ... ensured that he lived and grew stronger. //Even his mother Donna ... had to be given blood transfusions to recover. ,Now ... those who helped them, they are launching a campaign to fill ...
... has said that suicide rates in Sri Lanka has increased in ... yellow oleander plants even for the most trivial reasons. ... all over the island. It has yellow trumpet-like flowers and a ... seed and one of these seeds is enough to kill you, ...
... million Australians have diabetes. New South Wales (NSW) has recorded ... over the past 10 years. Experts have asked the health ... diabetes. Sooner if it continues it is expected that about ... reason for this increase is that of the diet and ...
Cached Medicine News:Health News:Hush…..A Deadly Killer on the Prowl in Rural Andhra Pradesh 2Health News:Proper Diagnosis Could Augment Speedy Recovery Of Haglund’s Syndrom 2Health News:Its High Time the Australian Government Takes Steps against Diabetes 2
(Date:5/22/2013)... , May 22, 2013 Pomerantz ... investigating claims on behalf of investors of Intuitive Surgical, ... ISRG ) (CUSIP: 46120E602) who purchased Intuitive Surgical common ... (the "Class Period"). Such investors are advised to contact ... rswilloughby@pomlaw.com or 888-476-6529, ext. 237. The ...
(Date:5/22/2013)... Minn. , May 22, 2013 /PRNewswire/ ... the successful completion of its global Phase ... an internally developed program for the management ... proprietary formulation technology.  USL255 is specifically engineered ... fluctuations in topiramate blood levels observed with ...
(Date:5/22/2013)... Mass. and TORONTO , ... ) (OTCBB: GNBT) today announced three presentations demonstrating the ... by its wholly-owned subsidiary, Antigen Express, Inc. ( www.antigenexpress.com ... meeting of the American Society of Clinical Oncology (ASCO) ... from May 31 through June 4, 2013. ...
Breaking Medicine Technology:SHAREHOLDER ALERT: Pomerantz Law Firm Investigates Claims On Behalf of Investors of Intuitive Surgical, Inc. - ISRG 2Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 2Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 3Upsher-Smith Successfully Completes Phase III Study Of USL255 (Extended-Release Topiramate) For Adjunctive Treatment Of Epilepsy In Patients With Refractory Partial-Onset Seizures 4Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 2Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 3Generex Announces ASCO Presentations on the Antigen Express Advanced Stage AE37 Cancer Vaccine 4
Very fine, blunt tip....
... Designed to meet the ... of cardiology practices. The ... attenuation correction accessory features ... array that increases the ...
Stainless steel lancet blade in stainless steel....
In Stainless steel. Available in 1.5, 2.0,3.0 & 3.5 MM...
Medicine Products: