Navigation Links
Research suggests mechanism for acne drug's link to depression
Date:11/12/2007

New research has found that a drug used to treat severe forms of acne reduces the availability of the chemical serotonin, low levels of which have been linked to aggression and clinical depression.

In a study published in the journal Experimental Biology and Medicine, scientists reveal a potential mechanism that might link the drug Roaccutane (Accutane in the US) to reported cases of depression in some patients taking the medication.

The researchers had previously reported that the drug caused depressive behaviour in mice but, until now, the mechanism by which this might happen was unknown.

Using cells cultured in a laboratory, scientists from the University of Bath (UK) and University of Texas at Austin (USA) were able to monitor the effect of the drug on the chemistry of the cells that produce serotonin.

They found that the cells significantly increased production of proteins and cell metabolites that are known to reduce the availability of serotonin.

This, says scientists, could disrupt the process by which serotonin relays signals between neurons in the brain and may be the cause of depression-related behaviour.

Serotonin is an important chemical that relays signals from nerve cells to other cells in the body, said Dr Sarah Bailey from the Department of Pharmacy & Pharmacology at the University of Bath.

In the brain it is thought to play an important role in the regulation of a range of behaviours, such as aggression, anger and sleep.

Low levels of serotonin have been linked to depression, as well as bipolar and anxiety disorders.

Many medications aimed at treating depression seek to increase levels of serotonin to help overcome these problems.

Our findings suggest that Roaccutane might disrupt the way serotonin is produced and made available to the cells.

This could result in problems associated with low levels of serotonin, which might include depression.'/>"/>

Contact: Andrew McLaughlin
a.mclaughlin@bath.ac.uk
44-012-253-86883
University of Bath
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... drug users in Russia might contribute to HIV ... conducted by researchers from Boston University Schools of ... Petersburg Pavlov State University, sought to discover the ... of a cohort of HIV-positive people with lifetime ... arrested by police were more likely to share ...
(Date:7/9/2014)... 2014) Researchers from Montefiore Medical Center ... of Yeshiva University will present new findings at the ... July 17 in Copenhagen, Denmark. Data from the ... transition from cognitive normality to mild cognitive impairment and ... Aging Study , established in 1980 to examine healthy ...
(Date:7/9/2014)... most important organs in the human body. Its job ... this is its synthesis function and that ... is its detoxification function. Lack of exercise and too ... liver. The resulting diseased cells can lead to inflammations, ... According to the German Liver Foundation, over five million ...
(Date:7/9/2014)... A study published in the scientific journal Nature ... two researchers at Universit Laval, reveals that it is ... that involves rekindling pain so that it can subsequently ... to alleviate chronic pain. , The researchers from the ... en sant mentale de Qubec (IUSMQ) were inspired by ...
(Date:7/8/2014)... of Defense,s Defense Advanced Research Projects Agency (DARPA) ... $2.5 million to develop an implantable neural device ... within the brain to help restore memory, DARPA ... on the understanding that memory is a process ... brain encode information, store it and retrieve it. ...
Breaking Medicine News(10 mins):Health News:BU researchers relate arrests with HIV risk environment 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 3Health News:Telemedicine for patients with chronic liver diseases 2Health News:Telemedicine for patients with chronic liver diseases 3Health News:Discovery of a new means to erase pain 2Health News:DARPA selects Lawrence Livermore to develop world's first neural device to restore memory 2Health News:DARPA selects Lawrence Livermore to develop world's first neural device to restore memory 3
... new Maui Jim sunglasses results in a donation of a pair ... June 24 Effective today and extending through July 31st, every ... http://www.mauijim.com will result in a donation ... the preeminent non-profit group dedicated to improvement of eye health and ...
... TO OPEN NEXT SPRING IN HOUSTON METROPOLITAN AREA ... Senior Living, Inc. (OTC Bulletin Board: TCSR), which develops, manages ... of a funding agreement with a national lender for the ... Texas metropolitan area. Funding for Trinity Terrace , ...
... How happy are you? Would you like to be,happier? Join TopTips.com,s Campaign ... What is it? , TopTips.com,s Campaign for Happiness ... a long time by bringing you Top Tips for,Happiness. , ... nation to,commit and asking you to send in your own Top Tips ...
... , -- New Claims Cover Use of Phosphatidylserine-Targeting Antibodies to ... , -- Supported by Published Data Showing Utility of PS-Targeting ... , TUSTIN, Calif., June 24 Peregrine Pharmaceuticals, Inc. (Nasdaq: ... U.S. patent with broad claims covering vascular imaging applications for ...
... Health Services, Inc. (Nasdaq: GTIV ), a leading ... has acquired Mid-State Home Health, one of central Louisiana,s top-three ... covers a 50-mile radius from its base in Alexandria that ... currently operate in this coverage area, but does provide services ...
... Percent of Surveyed Physicians Will Increase Their Use of ... New Report from AMR and Decision Resources , ... -- Arlington Medical Resources (AMR) and Decision ... formulation is a leading drug attribute that surveyed physicians ...
Cached Medicine News:Health News:Maui Jim Teams With Unite for Sight in New 'Buy One, Give One' Program to Improve Eye Health Amongst the World's Most Needy 2Health News:Maui Jim Teams With Unite for Sight in New 'Buy One, Give One' Program to Improve Eye Health Amongst the World's Most Needy 3Health News:TrinityCare Senior Living Announces Funding Agreement for Fourth Senior Living Facility 2Health News:The Secret of Happiness 2Health News:The Secret of Happiness 3Health News:Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform 2Health News:Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform 3Health News:Peregrine Pharmaceuticals Awarded Broad New U.S. Patent for Vascular Imaging Applications of Its PS-Targeting Platform 4Health News:Gentiva(R) Health Services Acquires Louisiana Home Health Agency 2Health News:Gentiva(R) Health Services Acquires Louisiana Home Health Agency 3Health News:Availability in Both Intravenous and Oral Formulation is a Leading Drug Attribute Surveyed Physicians Prefer for the Treatment of Urinary Tract Infections in the Hospital Setting 2Health News:Availability in Both Intravenous and Oral Formulation is a Leading Drug Attribute Surveyed Physicians Prefer for the Treatment of Urinary Tract Infections in the Hospital Setting 3
(Date:1/14/2014)... Jan. 14, 2014 InformEx, North America,s ... high-value chemistry, will hold the 30 th edition of ... Convention Center from January 21-24. (Logo: ... top pharmaceutical, fine chemical and specialty chemical companies will take ...
(Date:1/14/2014)... 14, 2014 /PRNewswire-iReach/ -- Acumed,s new SLIC Screw System ... accompanying instrumentation to place and insert the screw accurately ... tissue (e.g. ligament) repair or reconstruction as it holds ... (Photo: http://photos.prnewswire.com/prnh/20140114/MN45636 ) The ...
(Date:1/14/2014)... , Jan. 14, 2014 NineSigma , Inc., ... its Innovation Leadership Summit , May 14-16, 2014 ... Cleveland Ohio . This ... organizations committed to breakthrough achievements through open innovation. Participants ...
Breaking Medicine Technology:Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 2Acumed introduces the Scapho-Lunate Inter Carpal (SLIC) Screw System 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... , NEW YORK, Dec. ... report is available in its catalogue: , Ambulatory ... , http://www.reportlinker.com/p0164274/Ambulatory-and-Bathroom-Aids---A-Worldwide-Market-Review.html , Globally consumer spending on ... by steadily ageing population and rise in diseases associated ...
... ... a new market research report is available in its ... Market Review , http://www.reportlinker.com/p0164337/Radiation-Therapy-Equipment---A-Global-Market-Review.html , Cancer ... cancer cases diagnosed each year. Radiation therapy is the ...
Cached Medicine Technology:Reportlinker Adds Ambulatory and Bathroom Aids - A Worldwide Market Review 2Reportlinker Adds Ambulatory and Bathroom Aids - A Worldwide Market Review 3Reportlinker Adds Ambulatory and Bathroom Aids - A Worldwide Market Review 4Reportlinker Adds Ambulatory and Bathroom Aids - A Worldwide Market Review 5Reportlinker Adds Ambulatory and Bathroom Aids - A Worldwide Market Review 6Reportlinker Adds Ambulatory and Bathroom Aids - A Worldwide Market Review 7Reportlinker Adds Ambulatory and Bathroom Aids - A Worldwide Market Review 8Reportlinker Adds Ambulatory and Bathroom Aids - A Worldwide Market Review 9Reportlinker Adds Ambulatory and Bathroom Aids - A Worldwide Market Review 10Reportlinker Adds Ambulatory and Bathroom Aids - A Worldwide Market Review 11Reportlinker Adds Radiation Therapy Equipment - A Global Market Review 2Reportlinker Adds Radiation Therapy Equipment - A Global Market Review 3Reportlinker Adds Radiation Therapy Equipment - A Global Market Review 4Reportlinker Adds Radiation Therapy Equipment - A Global Market Review 5Reportlinker Adds Radiation Therapy Equipment - A Global Market Review 6Reportlinker Adds Radiation Therapy Equipment - A Global Market Review 7Reportlinker Adds Radiation Therapy Equipment - A Global Market Review 8
... generators are meeting the clinical needs ... and anesthesiologists. And, they are of ... from Medtronic.,Effective pacing with the adjustment ... for quick battery changes. Both ...
... CardioVad is a unique left ventricular assist device ... It is being used in a small group ... as part of an FDA-approved Feasibility Study. The ... the external power source for minutes or hours. ...
... Inc. has introduced the world's first minimally-invasive ... 10626 Epicardial Lead Implant Tool, which has ... States, will expand the options available to ... 5071 lead on the heart during pacemaker ...
The Schiller treadmill ergometer is designed for stress tests, sports medicine and cardiology. It is equipped and tested with the latest safety system and has been manufactured under the stringent qu...
Medicine Products: