Navigation Links
Research suggests mechanism for acne drug's link to depression
Date:11/12/2007

New research has found that a drug used to treat severe forms of acne reduces the availability of the chemical serotonin, low levels of which have been linked to aggression and clinical depression.

In a study published in the journal Experimental Biology and Medicine, scientists reveal a potential mechanism that might link the drug Roaccutane (Accutane in the US) to reported cases of depression in some patients taking the medication.

The researchers had previously reported that the drug caused depressive behaviour in mice but, until now, the mechanism by which this might happen was unknown.

Using cells cultured in a laboratory, scientists from the University of Bath (UK) and University of Texas at Austin (USA) were able to monitor the effect of the drug on the chemistry of the cells that produce serotonin.

They found that the cells significantly increased production of proteins and cell metabolites that are known to reduce the availability of serotonin.

This, says scientists, could disrupt the process by which serotonin relays signals between neurons in the brain and may be the cause of depression-related behaviour.

Serotonin is an important chemical that relays signals from nerve cells to other cells in the body, said Dr Sarah Bailey from the Department of Pharmacy & Pharmacology at the University of Bath.

In the brain it is thought to play an important role in the regulation of a range of behaviours, such as aggression, anger and sleep.

Low levels of serotonin have been linked to depression, as well as bipolar and anxiety disorders.

Many medications aimed at treating depression seek to increase levels of serotonin to help overcome these problems.

Our findings suggest that Roaccutane might disrupt the way serotonin is produced and made available to the cells.

This could result in problems associated with low levels of serotonin, which might include depression.

We are currently looking into this mechanism in more detail.


'/>"/>

Contact: Andrew McLaughlin
a.mclaughlin@bath.ac.uk
44-012-253-86883
University of Bath
Source:Eurekalert

Related medicine news :

1. Stanford researchers find culprit in aging muscles that heal poorly
2. Children of depressed moms do better when dad is involved, SLU researcher finds
3. UCLA researchers identify markers that may predict diabetes in still-healthy people
4. Mayo Clinic researchers discover new diagnostic test for detecting infection in prosthetic joints
5. New research shows how chronic stress worsens neurodegenerative disease course
6. New research explores newborn in-hospital weight loss
7. Research may unlock mystery of autisms origin in the brain
8. Bipolar disorder relapses halved by Melbourne researchers
9. HIVs impact in Zimbabwe explored in new research
10. U.S. Research Funding Continues to Flatten as U.S. Health Costs Climb - in August 31 Science
11. Cell that triggers symptoms in allergy attacks can also limit damage, Stanford researchers find
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... ... January 24, 2017 , ... Learn to use popular ... or even in relationships. Course offered by Dr. Carol Francis at PVNET on ... limited seating and the many hands-on experiences. , Dr. Carol Francis shows ...
(Date:1/24/2017)... ... January 24, 2017 , ... ... that its annual Solutions Series of webinars will start January 31 with a ... a number of current health and benefits topics, including employee engagement, pricing transparency, ...
(Date:1/24/2017)... ... January 24, 2017 , ... Bellus Medical, a leader in medical ... experts. In his new role Dr. Dobke will provide physician oversight for in-house clinical ... the Head of Plastic Surgery and Associate Professor of Surgery at UC San Diego ...
(Date:1/24/2017)... N.C. (PRWEB) , ... January 24, 2017 , ... ... Administration is the focus of a new report from the Frank Hawkins ... Business School. , Influential business leaders, academics and policy makers identified concrete solutions ...
(Date:1/24/2017)... ... January 24, 2017 , ... The results from the ... everyone and particularly good news for prostate cancer patients: incidents of cancer is down ... to the report the cancer death rate has dropped from its peak of 215.1 ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... 2017 Sherpa Clinical Packaging ( www.sherpaclinical.com ... is pleased to announce the appointment of Kevin Rosenthal as ... Sherpa team to lead Sherpa,s Operations group and ... excellence. Kevin is not new to ... He has extensive experience working for leading pharma ...
(Date:1/24/2017)... and PUNE, India , January 24, 2017 ... Allied Market Research, titled, "Acidity Regulators Market - Global ... for acidity regulators was valued at $4,456 million in 2015, and ... CAGR of 7.96% from 2016 to 2022. Asia-Pacific ... maintain its lead, followed by North America ...
(Date:1/24/2017)... , January 24, 2017 ... value of USD 3.8 billion by 2025, according to ... market growth can be attributed to the rising initiatives ... early diagnosis of micro calcifications in breast tissue. Some ... CDC, and Breast Cancer Organization are promoting the early ...
Breaking Medicine Technology: