Navigation Links
Research suggests link between infertility, low egg reserve, and breast/ovarian cancer gene (BRCA1)
Date:12/18/2009

A New York Medical College physician who specializes in restoring or preserving fertility in female cancer patients has discovered a possible link between the presence of breast cancer genes and infertility.

In a paper published last week in the Journal of Clinical Oncology, Kutluk Oktay, M.D., professor of obstetrics and gynecology and principal investigator on the study, concluded that mutations in the BRCA1 gene, which have been linked with early onset breast cancer, are also associated with an early loss of egg reserves. This finding may help to explain why women who carry a mutated BRCA1 gene have greater rates of infertility as well as a greater risk for breast and ovarian cancer.

Dr. Oktay's team performed ovarian stimulation in 126 women with breast cancer for the purpose of fertility preservation by embryo or oocyte cryopreservation. The results showed that of the 82 women who met the inclusion criteria, 47 women (57 percent) had undergone BRCA testing, with 14 having a mutation in BRCA genes. In BRCA mutation-positive patients, the low ovarian response rate was significantly greater than for patients who did not show BRCA gene mutations, nor for women who had not been tested for the gene at all.

If fertility drugs are not as effective in stimulating egg production in the ovaries of patients who carry BRCA1 mutations, this establishes a link between infertility and the risk of getting breast or ovarian cancer, Dr. Oktay concludes.

It is estimated that in the general population, one in every 1,000 women is BRCA mutation positive, with the incidence as high as 2.5 percent in certain ethnic groups such as Ashkenazi Jews. Researchers have identified hundreds of mutations in the BRCA1 gene, many already associated with an increased risk of cancer. This means that the mutations in BRCA1 gene may affect egg reserve and fertility of a significant number of women in the U.S.


'/>"/>

Contact: Donna E. Moriarty, M.P.H.
donna_moriarty@nymc.edu
914-594-4536
New York Medical College
Source:Eurekalert

Page: 1

Related medicine news :

1. Bill & Melinda Gates Foundation Grants $5 Million For Infectious Disease Research At The Hebrew University Of Jerusalem
2. China rapidly catching up in research impact
3. Vision researchers Jay and Maureen Neitz to receive first Pepose Award from Brandeis
4. Hebrew U. receives $5 million for research on leishmaniasis in Ethiopia
5. Umbilical cord could be new source of plentiful stem cells, say Pitt researchers
6. Most Stem Cells Used in Research Come From Whites
7. House Creates New Cancer Research Program
8. Researchers discover novel method for detecting MIRCERA
9. Julian Lennon and James Scott Cook Release New Charity Single LUCY to Raise Awareness and Funds for Lupus Research
10. Knowledge Networks Expands in Pharma Research With Acquisition of CMR
11. Comcast and Stand Up To Cancer Launch First-Ever Video-on-Demand Effort to Broaden Awareness and Raise Funds for Cancer Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2015)... Petersburg, FL (PRWEB) April 28, 2015 ... Health System were named to Becker's Hospital Review’s ... Safety . Peter Pronovost, M.D., Ph.D. , director ... Quality and senior vice president for patient safety ... Mueller, M.D., M.H.C.M. , vice president of medical affairs ...
(Date:4/28/2015)... 2015 The popular all-natural supplement brand, ... their newly launched L-Style Revolution Program™, and collectively the ... in just two short months. The customized weight ... plan for men and women of all health and ... and weight maintenance goals faster than traditional methods. , ...
(Date:4/28/2015)... (PRWEB) April 28, 2015 An ... Blair A. Jobe, MD, FACS , has launched the ... tissue with extracellular matrix (ECM) can help patients who ... of esophageal cancer. , ECM is a complex mixture ... attachment and migration and signals that guide cell behavior. ...
(Date:4/28/2015)... As the Muscular Dystrophy Association continues ... the organization has hired Scientific Program Officer Lianna ... Fidelity Biosciences Research Initiative where, as Associate Director, ... diseases such as Alzheimer’s Disease, and organized and ... Fidelity, she was a junior faculty member at ...
(Date:4/28/2015)... 28, 2015 Researchers from four US ... of a steroid prior to pemetrexed (Alimta) chemotherapy may ... Click here to read the full story ... the Raabe College of Pharmacy in Ohio, Stanford Cancer ... Regional Healthcare in Kentucky gave a single dose of ...
Breaking Medicine News(10 mins):Health News:Johns Hopkins Medicine and All Children’s Hospital Leaders Recognized as Top Experts in Patient Safety 2Health News:Johns Hopkins Medicine and All Children’s Hospital Leaders Recognized as Top Experts in Patient Safety 3Health News:Johns Hopkins Medicine and All Children’s Hospital Leaders Recognized as Top Experts in Patient Safety 4Health News:Sports Nutrition Supplement Brand, Liporidex, Is Making History With Its New L-Style Revolution Diet & Exercise Program Reaching Over 10,000 Pounds Lost In Two Months 2Health News:Sports Nutrition Supplement Brand, Liporidex, Is Making History With Its New L-Style Revolution Diet & Exercise Program Reaching Over 10,000 Pounds Lost In Two Months 3Health News:Allegheny Health Network Launches First U.S. Clinical Trial of Extracellular Matrix as Replacement for Pre-Cancerous Tissue 2Health News:Allegheny Health Network Launches First U.S. Clinical Trial of Extracellular Matrix as Replacement for Pre-Cancerous Tissue 3Health News:MDA Adds Neurological Disease Expert to Research Team 2Health News:MDA Adds Neurological Disease Expert to Research Team 3Health News:Study Finds New Regimen May Ward Off Skin Rash from Common Mesothelioma Drug, According to Surviving Mesothelioma 2
... Jersey has its share of underserved children, according to a ... state,s children between 3 and 18 received no dental care ... almost one-third of the state,s children received no care, the ... were still likely to forgo visits to the dentist. ...
... EDITOR,S PICK: Predicting resistance to brain tumor chemotherapy ... lethal of all human brain tumors that originate in ... by both radiation therapy and chemotherapy with temozolomide. However, ... A team of researchers led by Sameer Agnihotri, at ...
... Medicine (BUSM) have identified for the first time the ... target against atherosclerosis resulting from a diet high in ... Circulation , may have significant public health implications. ... at low levels, and at higher levels during exercise ...
... have discovered how malaria manipulates the immune system to allow ... immune system pathway, the research team was able to cure ... published Dec. 11 in the Advance Online Publication of the ... a new approach for treating malaria that does not rely ...
... seedlings is important to crop growth and yield after ... stems, thick leaves, dark green leaves, and large white ... physiology are strongly influenced by the light spectrum, which ... has been shown to increase crop yield after planting ...
... December 11, 2011) Lymphoma and myeloma are both ... blood cells, and commonly involve lymph nodes and the ... the treatment of these diseases, they remain a significant ... unique treatment approaches and targets for lymphoma and myeloma ...
Cached Medicine News:Health News:Rutgers Study: When it comes to use of dental services, not all NJ youngsters are equal 2Health News:Rutgers Study: When it comes to use of dental services, not all NJ youngsters are equal 3Health News:JCI online early table of contents: Dec. 12, 2011 2Health News:JCI online early table of contents: Dec. 12, 2011 3Health News:JCI online early table of contents: Dec. 12, 2011 4Health News:JCI online early table of contents: Dec. 12, 2011 5Health News:JCI online early table of contents: Dec. 12, 2011 6Health News:JCI online early table of contents: Dec. 12, 2011 7Health News:JCI online early table of contents: Dec. 12, 2011 8Health News:JCI online early table of contents: Dec. 12, 2011 9Health News:Researchers identify agent responsible for protection against early stages of atherosclerosis 2Health News:Researchers use new finding to clear bloodstream malaria infection in mice 2Health News:Researchers use new finding to clear bloodstream malaria infection in mice 3Health News:Blue light irradiation promotes growth, increases antioxidants in lettuce seedlings 2Health News:Emerging lymphoma and myeloma treatments focus on improving individual patient response 2Health News:Emerging lymphoma and myeloma treatments focus on improving individual patient response 3Health News:Emerging lymphoma and myeloma treatments focus on improving individual patient response 4Health News:Emerging lymphoma and myeloma treatments focus on improving individual patient response 5Health News:Emerging lymphoma and myeloma treatments focus on improving individual patient response 6Health News:Emerging lymphoma and myeloma treatments focus on improving individual patient response 7Health News:Emerging lymphoma and myeloma treatments focus on improving individual patient response 8Health News:Emerging lymphoma and myeloma treatments focus on improving individual patient response 9
(Date:4/28/2015)... ANGELES , April 28, 2015  Illnesses know no ... with our places of business. If you,ve ever woken up ... are as sick as the proverbial dog, or if you,ve ... figure out how to fit it into your schedule, you,ve ... M.D. of House Call Doctor Los Angeles offers an alternative ...
(Date:4/28/2015)... DALLAS , April 28, 2015   Generational ... privately-held, middle-market businesses, is pleased to announce the acquisition ... Cuero, Texas , by Lifecare Pharmacy headquartered ... acquisition closed on April 1, 2015. ... known community pharmacy and retailer of durable medical equipment. ...
(Date:4/28/2015)... 28, 2015 Konica Minolta Medical Imaging ... growth for fiscal year ended March 31, 2015, ... of Primary Imaging Solutions.  The success of the ... to double digit sales figures exceeding expectations.  The ... AeroDR XE, a wireless flat panel detector, specially ...
Breaking Medicine Technology:Your Health and Your Schedule Should not be at War 2Generational Equity Announces the Acquisition of Reuss Pharmacies Inc. by Lifecare Pharmacy 2Konica Minolta Sets Record Digital Radiography Sales 2
... The Small Joint Ball Electrode ... in small joint applications. With its ... tip, controlled capsuloligamentous or tendinous tissue ... When used in conjunction with the ...
... is designed to replace the carpal scaphoid bone. ... pole which fits under a shelf formed in ... suture hole on the proximal hole for suture ... the early postoperative period until a firm capsuloligamentous ...
... Kompressor is a two-piece Titanium (Ti-6Al-4V) screw ... and a variety of lengths. The two ... and sterile packaged. A single instrument set ... removal of both Standard and Mini Kompressor ...
... Total Wrist System was the first wrist implant ... wrist. Since then it has become the leading ... ,During total wrist replacement surgery, doctors remove scar ... replacement implant in place of the damaged wrist. ...
Medicine Products: