Navigation Links
Research suggests link between infertility, low egg reserve, and breast/ovarian cancer gene (BRCA1)
Date:12/18/2009

A New York Medical College physician who specializes in restoring or preserving fertility in female cancer patients has discovered a possible link between the presence of breast cancer genes and infertility.

In a paper published last week in the Journal of Clinical Oncology, Kutluk Oktay, M.D., professor of obstetrics and gynecology and principal investigator on the study, concluded that mutations in the BRCA1 gene, which have been linked with early onset breast cancer, are also associated with an early loss of egg reserves. This finding may help to explain why women who carry a mutated BRCA1 gene have greater rates of infertility as well as a greater risk for breast and ovarian cancer.

Dr. Oktay's team performed ovarian stimulation in 126 women with breast cancer for the purpose of fertility preservation by embryo or oocyte cryopreservation. The results showed that of the 82 women who met the inclusion criteria, 47 women (57 percent) had undergone BRCA testing, with 14 having a mutation in BRCA genes. In BRCA mutation-positive patients, the low ovarian response rate was significantly greater than for patients who did not show BRCA gene mutations, nor for women who had not been tested for the gene at all.

If fertility drugs are not as effective in stimulating egg production in the ovaries of patients who carry BRCA1 mutations, this establishes a link between infertility and the risk of getting breast or ovarian cancer, Dr. Oktay concludes.

It is estimated that in the general population, one in every 1,000 women is BRCA mutation positive, with the incidence as high as 2.5 percent in certain ethnic groups such as Ashkenazi Jews. Researchers have identified hundreds of mutations in the BRCA1 gene, many already associated with an increased risk of cancer. This means that the mutations in BRCA1 gene may affect egg reserve and fertility of a significant number of women in the U.S.


'/>"/>

Contact: Donna E. Moriarty, M.P.H.
donna_moriarty@nymc.edu
914-594-4536
New York Medical College
Source:Eurekalert

Page: 1

Related medicine news :

1. Bill & Melinda Gates Foundation Grants $5 Million For Infectious Disease Research At The Hebrew University Of Jerusalem
2. China rapidly catching up in research impact
3. Vision researchers Jay and Maureen Neitz to receive first Pepose Award from Brandeis
4. Hebrew U. receives $5 million for research on leishmaniasis in Ethiopia
5. Umbilical cord could be new source of plentiful stem cells, say Pitt researchers
6. Most Stem Cells Used in Research Come From Whites
7. House Creates New Cancer Research Program
8. Researchers discover novel method for detecting MIRCERA
9. Julian Lennon and James Scott Cook Release New Charity Single LUCY to Raise Awareness and Funds for Lupus Research
10. Knowledge Networks Expands in Pharma Research With Acquisition of CMR
11. Comcast and Stand Up To Cancer Launch First-Ever Video-on-Demand Effort to Broaden Awareness and Raise Funds for Cancer Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements ... that was developed to enhance the health of felines. The formula is all-natural and ... main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews are ...
(Date:6/26/2016)... Birmingham, Lake Orion, Clarkston, Michigan (PRWEB) , ... ... ... their direction with respect to fertility once they have been diagnosed with endometriosis. ... for tolerable intercourse but they also require a comprehensive approach that can help ...
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... Aliso Viejo, California (PRWEB) , ... June 25, 2016 , ... ... preset to fit their specific project," said Christina Austin - CEO of Pixel Film ... all fully customizable and all within Final Cut Pro X . Simply select ...
(Date:6/25/2016)... ... , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his Bachelors ... Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps Green ... hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to train ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/23/2016)...  MedSource announced today that it has selected ... of choice.  This latest decision demonstrates MedSource,s commitment ... clients by offering a state-of-the-art electronic data capture ... as the EDC platform of choice in exchange ... has long been a preferred EDC platform by ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
Breaking Medicine Technology: