Navigation Links
Research suggests a blood test to locate gene defects associated with cancer may not be far off
Date:1/8/2014

HOUSTON, TX - Some surprising research findings from scientists at The University of Texas MD Anderson Cancer Center suggest it's possible a simple blood test could be developed to determine whether gene mutations associated with pancreatic cancer exist without the need of locating and testing tumor tissue. This appears possible following the discovery that tiny particles the size of viruses called 'exosomes,' which are shed by cancer cells into the blood, contain the entire genetic blueprint of cancer cells. By decoding this genomic data and looking for deletions and mutations associated with cancer, the research team believes this discovery could be translated into a test that helps physicians detect cancer and treat patients. The findings are based on research led by Raghu Kalluri, M.D., Ph.D., chairman and professor in MD Anderson's Department of Cancer Biology. The research results appear in the current online edition of the Journal of Biological Chemistry.

"At the present time, there is no single blood test that can screen for all cancer related DNA defects," said Kalluri. "In many cases, current protocols require a tumor sample to determine whether gene mutations and deletions exist and therefore determine whether the tumor itself is cancerous or benign. To procure tumor tissue, one needs to know that a tumor exists and if so, is it accessible for sample collection or removal? Finally, there are always risks and significant costs associated with surgical procedures to acquire tumor tissue."

Historically, researchers were aware these miniscule particles existed and that they carried nucleic acids and proteins. It was also believed that exosomes carried small portions of the person's DNA. However, upon further investigation, the MD Anderson research team was surprised to learn that the person's entire double-stranded genomic DNA spanning all chromosomes can be found in exosomes, including those mutated chromosomes that cause various cancers. Furthermore, Kalluri and colleagues discovered that DNA derived from exosomes carried the same cancer-related genetic mutations compared to the cancer cells taken from tumor.

"Because different forms of cancer are associated with different chromosomal mutations , we believe analysis of exosome DNA taken from blood samples may not only help determine the presence of a cancerous tumor somewhere in the body but also identify mutations without a need for tumor sample," added Kalluri. "We also believe this "fingerprint" will help lead us to the likely site of the tumor in the body. For instance, certain mutation spectrums would suggest pancreatic cancer or a brain-based tumor. While there is much more work to be conducted to develop such a test, having a tool such as this would increase our abilities to detect cancer in an earlier stage and therefore increase our chances of effective treatment."

"This seminal discovery paves the way for highly sensitive screening for driver mutations of cancer in the blood without the need for biopsy of tumor tissue and importantly, lays the foundation for a new method for the early detection of cancer when the chance for cure is greatest," said MD Anderson President Ronald A. DePinho, M.D.


'/>"/>

Contact: Jim Newman
jnewman@mdanderson.org
713-792-0662
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Related medicine news :

1. Global Teleradiology Market Is Expected to Reach USD 3.78 Billion in 2019: Transparency Market Research
2. North America to Lead Flow Cytometry Market Till 2020, States Allied Market Research in Its Report Published at MarketPublishers.com
3. Light fantastic -- Cable announces £3.6 million for manufacturing research
4. Family Voices Awarded Project to Fight Childhood Obesity by the Patient-Centered Outcomes Research Institute
5. German Research Foundation approves research unit to study extreme experiences in life
6. SckoonCup Research Shows Revolutionary Trend in Feminine Care - Women Seek Healthier Alternatives to Tampons as Use of Menstrual Cups Soar 500%
7. Growth of Mice Model Industry (Oncology, Immunology, CNS) with 2018 Forecasts in a New Research Report at RnRMarketResearch.com
8. Winter Dry Eye Season Causes Blurred Vision Warns Dry Eye Researcher
9. Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
10. Monoclonal Antibodies Market in Gastric and Esophageal Cancers to Reach USD 766 Mln by 2019, Says GBI Research in Its Report Available at MarketPublishers.com
11. Water Treatment Chemicals Procurement Research Report Now Available from IBISWorld
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/16/2017)... ... 2017 , ... Permobil has just completed the acquisition of ... systems has a well-earned reputation for premium quality, with a focus on fit ... in the custom seating business, which enjoys strong demand, and it complements Permobil’s ...
(Date:1/16/2017)... ... January 16, 2017 , ... ... teacher, http://www.ageofautism.com/legal , Sharon Kleyne, America’s leading water educator, researcher and ... nationally syndicated radio program, The Sharon Kleyne Hour Power of Water, Global Climate ...
(Date:1/16/2017)... ... January 16, 2017 , ... San Francisco dentist, Dr. Ben ... in 3-D scanning device which is capable of taking digital impressions of teeth and ... such as CAD CAM restorations , in terms of speed, efficiency and patient ...
(Date:1/15/2017)... ... 15, 2017 , ... Going above and beyond the practical ... better communities around the world by offering the Gensuite team and their services ... team members to become involved in a cause that is bigger than themselves ...
(Date:1/15/2017)... ... January 15, 2017 , ... ... physicians in eight Bay Area counties for 2017. Almost 1,000 nominations were submitted ... managing the award process. Results were announced the magazine’s January 2017 issue ...
Breaking Medicine News(10 mins):
(Date:1/16/2017)... Jan. 16, 2017  An aneurysm develops due to the ... Aneurysms can occur in any artery, it happens ... that supplies blood to legs. Most aortic aneurysms occur in ... and are referred as abdominal aortic aneurysms, sometimes in the ... the aorta in the abdomen is about 2 cm but ...
(Date:1/16/2017)... ® Inc., a leading manufacturer and marketer of imaging and ... Spectrum TM Single-Use video laryngoscopes. The new Spectrum ... Reduction TM technology, which actively optimizes image quality. ... ... Introducing another bright idea from GlideScope(R) Video Laryngoscopes: ...
(Date:1/16/2017)... 16, 2017  According to Kalorama Information, the ... valued at $4.9 billion for 2016.  The growing ... an aging population with significant diagnostic needs, along ... propelling the market for the modality.  The healthcare ... , focuses on the worldwide market, providing market ...
Breaking Medicine Technology: